CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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UT6150000
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CHEMICAL NAME :
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Pyridine, 2-((methylsulfinyl)acetyl)-
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CAS REGISTRY NUMBER :
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27302-90-5
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BEILSTEIN REFERENCE NO. :
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1526159
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LAST UPDATED :
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199612
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DATA ITEMS CITED :
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10
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MOLECULAR FORMULA :
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C8-H9-N-O2-S
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MOLECULAR WEIGHT :
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183.24
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WISWESSER LINE NOTATION :
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T6NJ BV1SO&1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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6550 mg/kg
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TOXIC EFFECTS :
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Sense Organs and Special Senses (Eye) - ptosis Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia
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REFERENCE :
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TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 36,49,1976
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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1800 mg/kg
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TOXIC EFFECTS :
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Sense Organs and Special Senses (Eye) - ptosis Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia
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REFERENCE :
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TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 36,49,1976
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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5280 mg/kg
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TOXIC EFFECTS :
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Sense Organs and Special Senses (Eye) - ptosis Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia
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REFERENCE :
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TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 36,49,1976
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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2510 mg/kg
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TOXIC EFFECTS :
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Sense Organs and Special Senses (Eye) - ptosis Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia
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REFERENCE :
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TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 36,49,1976
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Mammal - dog
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DOSE/DURATION :
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>5 gm/kg
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TOXIC EFFECTS :
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Gastrointestinal - nausea or vomiting
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REFERENCE :
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TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 36,49,1976
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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6610 mg/kg
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TOXIC EFFECTS :
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Sense Organs and Special Senses (Eye) - ptosis Behavioral - ataxia Gastrointestinal - nausea or vomiting
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REFERENCE :
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TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 36,49,1976 ** OTHER MULTIPLE DOSE TOXICITY DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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91 gm/kg/13W-I
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TOXIC EFFECTS :
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Liver - changes in liver weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - weight loss or decreased weight gain
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REFERENCE :
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TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 36,49,1976 ** TUMORIGENIC DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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437 gm/kg/2Y-C
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TOXIC EFFECTS :
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Tumorigenic - neoplastic by RTECS criteria Liver - tumors
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REFERENCE :
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TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 28,17,1983
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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336 gm/kg/80W-C
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors
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REFERENCE :
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TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 28,17,1983
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TYPE OF TEST :
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TD - Toxic dose (other than lowest)
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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437 gm/kg/2Y-C
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors
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REFERENCE :
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TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 3,145,1983
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