737-86-0

• 常用中文名：吡哆醛异烟酰腙(PIH)
• 常用英文名：Pyridoxal isonicotinoyl hydrazone
• CAS号：737-86-0
• 分子式：C₁₄H₁₄N₄O₃
• 分子量：286.29
• 相关类别： 研究领域 癌症
• 发布时间：2017-11-08 02:00:32
• 更新时间：2024-01-06 21:09:53
• Pyridoxal isonicotinoyl hydrazine (PIH) 是一种亲脂的三价铁螯合剂,显示出高铁螯合作用。

名称

• 中文名: 吡哆醛异烟酰腙
• 英文名: pih
• 英文别名: pyridoxal N-(isonicotinoyl)hydrazone; Pyridoxal hydrochloride 1GR; pyridoxal HCl; PL HCL; PyridoxalHydrochlorideMin.; Pyridoxal,Hydrochlorid; 3-hydroxy-5-hydroxymethyl-2-methyl-pyridine-4-carbaldehyde,hydrochloride; Pyridoxal-[2H3] hydrochloride; Pyridoxal hydrochloride 5GR; Pyridoxal hydrochlor; 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde,hydrochloride; pyridoxal isonicotinoyl hydrazone; Pyridoxalhydrochloride

物化性质

• 密度: 1.35g/cm3
• 分子式: C₁₄H₁₄N₄O₃
• 分子量: 286.29
• 精确质量: 286.10700
• PSA: 107.70000
• LogP: 1.13770
• 折射率: 1.646
• 储存条件: 2-8℃

生物活性

• 描述: Pyridoxal isonicotinoyl hydrazine (PIH) 是一种亲脂的三价铁螯合剂,显示出高铁螯合作用。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Hermes-Lima M, et al. The iron chelator pyridoxal isonicotinoyl hydrazone (PIH) and its analogues prevent damage to 2-deoxyribose mediated by ferric iron plus ascorbate. Biochim Biophys Acta. 2000 Oct 18;1523(2-3):154-60.

  [2]. Landschulz W, et al. A lipophilic iron chelator can replace transferrin as a stimulator of cell proliferation and differentiation. J Cell Biol. 1984 Feb;98(2):596-601.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : US5760000 CHEMICAL NAME : 4-Pyridinecarboxylic acid, ((3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinyl)me thylene) hydrazide CAS REGISTRY NUMBER : 737-86-0 LAST UPDATED : 199612 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C14-H14-N4-O3 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 5 gm/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Kidney, Ureter, Bladder - other changes in urine composition REFERENCE : DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 14,395,1991 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1100 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Liver - fatty liver degeneration REFERENCE : DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 14,395,1991 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 4500 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Kidney, Ureter, Bladder - other changes in urine composition REFERENCE : DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 14,395,1991 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1 gm/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Liver - fatty liver degeneration REFERENCE : DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 14,395,1991 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 72 gm/kg/90D-C TOXIC EFFECTS : Nutritional and Gross Metabolic - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases Related to Chronic Data - death REFERENCE : DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 14,395,1991