4498-32-2

• 常用中文名：二苯西平
• 常用英文名：Dibenzepin
• CAS号：4498-32-2
• 分子式：C₁₈H₂₁N₃O
• 分子量：295.37900
• 发布时间：2018-03-08 08:00:00
• 更新时间：2024-01-20 16:00:29

名称

• 中文名: 二苯西平
• 英文名: Dibenzepin
• 英文别名: 10-[2-(Dimethylamino)ethyl]-5,10-dihydro-5-methyl-11H-dibenzo[b,e][1,4]diazepin-11-one; 10-(2-dimethylamino-ethyl)-5-methyl-5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one; 5-(2-dimethylaminoethyl)-11-methyl-benzo[b][1,4]benzodiazepin-6-one; dibenzepine; 5-Methyl-10-[2-(dimethylamino)ethyl]-5H-dibenzo[b,e][1,4]diazepine-11(10H)-one; 10,11-Dihydro-10-[2-(dimethylamino)ethyl]-5-methyl-5H-dibenzo[b,e][1,4]diazepin-11-one; 10,11-Dihydro-5-methyl-10-[2-(dimethylamino)ethyl]-5H-dibenzo[b,e][1,4]diazepin-11-one; HF 1927; 5-Methyl-10-dimethylaminoethyl-10,11-dihydro-11-oxodibenzo[b,e][1,4]diazepine; dipenzepine

物化性质

• 密度: 1.134g/cm3
• 沸点: 451.7ºC at 760mmHg
• 熔点: 116-117ºC
• 分子式: C₁₈H₂₁N₃O
• 分子量: 295.37900
• 闪点: 194.9ºC
• 精确质量: 295.16800
• PSA: 30.17000
• LogP: 2.61700
• 折射率: 1.592

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : HP2499000 CHEMICAL NAME : 11H-Dibenzo(b,e)(1,4)diazepin-11-one, 5,10-dihydro-10-(2-(dimethylamino)ethyl)-5-methyl- CAS REGISTRY NUMBER : 4498-32-2 BEILSTEIN REFERENCE NO. : 0894708 LAST UPDATED : 199612 DATA ITEMS CITED : 9 MOLECULAR FORMULA : C18-H21-N3-O MOLECULAR WEIGHT : 295.42 WISWESSER LINE NOTATION : T C676 BN INVJ B1 I2N1&1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 220 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : INPHB6 International Pharmacopsychiatry. (Basel, Switzerland) V.1-17, 1968-72. Volume(issue)/page/year: 1,214,1968 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 70 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : INPHB6 International Pharmacopsychiatry. (Basel, Switzerland) V.1-17, 1968-72. Volume(issue)/page/year: 1,214,1968 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 542 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 6,119,1975 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 22 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : INPHB6 International Pharmacopsychiatry. (Basel, Switzerland) V.1-17, 1968-72. Volume(issue)/page/year: 1,214,1968 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 194 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 6,119,1975 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 60 mg/kg TOXIC EFFECTS : Behavioral - irritability REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 21,1727,1971 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 90 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 19,458,1969 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 22 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : INPHB6 International Pharmacopsychiatry. (Basel, Switzerland) V.1-17, 1968-72. Volume(issue)/page/year: 1,214,1968 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 5760 mg/kg/22W-I TOXIC EFFECTS : Cardiac - EKG changes not diagnostic of specified effects Cardiac - pulse rate increase, without fall in BP REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 30,1709,1980

安全

• 危险品运输编码: UN 3249
• 包装等级: III
• 危险类别: 6.1(b)
• 海关编码: 2933990090

海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%