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上海化源世纪贸易有限公司
上海市上海市普陀区
产品名：米那卜林二盐酸盐
纯度：99.0%
规格：
联系人：徐经理
联系电话：13311869306

上海创赛科技有限公司
上海市上海市嘉定区
产品名：[Perfemiker]Minaprine dihydrochloride,≥99%
纯度：99.0%
规格：100mg
联系人：夏言
联系电话：18016376636

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25953-17-7生产厂家

25953-17-7价格

25953-17-7

25953-17-7结构式

常用中文名：Minaprine dihydrochloride
常用英文名：Minaprine (dihydrochloride)
CAS号：25953-17-7
分子式：C₁₇H₂₄Cl₂N₄O
分子量：371.30
相关类别：信号通路神经信号通路单胺氧化酶
发布时间：2018-12-26 08:12:59
更新时间：2024-01-12 19:43:32
Minaprine二盐酸盐是单胺氧化酶MAO-A可逆性抑制剂，还对乙酰胆碱酯酶有微弱抑制，抗抑郁类化合物。

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中文名	4-甲基-N-(2-吗啉-4-乙基)-6-苯基吡嗪-3-胺
英文名	minaprine hydrochloride
英文别名	Ag 620 Agr 620 Pyridazine, 4-methyl-3-[(2-morpholinoethyl)amino]-6-phenyl-, dihydrochloride Agr 1240 4-Morpholineethanamine,N-(4-methyl-6-phenyl-3-pyridazinyl)-,dihydrochloride Morpholine,4-[2-[(4-methyl-6-phenyl-3-pyridazinyl)amino]ethyl]-,dihydrochloride Minaprine (dihydrochloride)

描述	Minaprine二盐酸盐是单胺氧化酶MAO-A可逆性抑制剂,还对乙酰胆碱酯酶有微弱抑制,抗抑郁类化合物。
相关类别	信号通路 >> 神经信号通路 >> 单胺氧化酶研究领域 >> 神经疾病
参考文献	[1]. Kan JP, et al. Effect of the antidepressant minaprine on both forms of monoamine oxidase in the rat. Biochem Pharmacol. 1986 Mar 15;35(6):973-8. [2]. Contreras JM, et al. Aminopyridazines as acetylcholinesterase inhibitors. J Med Chem. 1999 Feb 25;42(4):730-41.

沸点	531.2ºC at 760 mmHg
分子式	C₁₇H₂₄Cl₂N₄O
分子量	371.30
闪点	275.1ºC
PSA	50.28000
LogP	3.00900
蒸汽压	2.29E-11mmHg at 25°C
储存条件	2-8℃

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QE3477835

CHEMICAL NAME :: 4-Morpholineethanamine, N-(4-methyl-6-phenyl-3-pyridazinyl)-, dihydrochloride

CAS REGISTRY NUMBER :: 25953-17-7

LAST UPDATED :: 199707

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C17-H22-N4-O.2Cl-H

MOLECULAR WEIGHT :: 371.35

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >100 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 32,824,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 63 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4508720 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4823 mg/kg/13W-I

TOXIC EFFECTS :: Endocrine - changes in adrenal weight Endocrine - changes in thymus weight

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 24,1894,1990