CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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AR9244000
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CHEMICAL NAME :
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Acridine, 9-((3-(dimethylamino)propyl)amino)-1-nitro-, dihydrochloride
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CAS REGISTRY NUMBER :
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6514-85-8
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LAST UPDATED :
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199506
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DATA ITEMS CITED :
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11
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MOLECULAR FORMULA :
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C18-H20-N4-O2.2Cl-H
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MOLECULAR WEIGHT :
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397.34
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WISWESSER LINE NOTATION :
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T C666 BNJ GNW IM3N1&1 &GH 2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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25750 ug/kg
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TOXIC EFFECTS :
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Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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725 ug/kg
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TOXIC EFFECTS :
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Gastrointestinal - other changes
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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34050 ug/kg
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TOXIC EFFECTS :
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Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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1 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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1010 ug/kg
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TOXIC EFFECTS :
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Gastrointestinal - other changes
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Bird - pigeon
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DOSE/DURATION :
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1010 ug/kg
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TOXIC EFFECTS :
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Gastrointestinal - nausea or vomiting
MUTATION DATA
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TYPE OF TEST :
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Host-mediated assay
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TEST SYSTEM :
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Rodent - mouse Bacteria - Salmonella typhimurium
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DOSE/DURATION :
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500 ug/kg
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REFERENCE :
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PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25- 1973- Volume(issue)/page/year: 31,661,1979
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