14402-89-2

• 常用中文名：硝普酸钠
• 常用英文名：sodium nitroprusside
• CAS号：14402-89-2
• 分子式：C₅FeN₆Na₂O
• 分子量：261.91800
• 相关类别： 无机化工 无机盐 氰化物、氰氧化物及氰络合物
• 发布时间：2018-09-16 18:11:27
• 更新时间：2024-01-03 17:29:38
• Sodium Nitroprusside是血管舒张剂，能促使NO释放于血液中。

名称

• 中文名: 硝普酸钠
• 英文名: sodium nitroprusside
• 英文别名: Nitroprusside (Sodium)

物化性质

• 密度: 1.72
• 分子式: C₅FeN₆Na₂O
• 分子量: 261.91800
• 精确质量: 261.92800
• PSA: 148.38000
• LogP: 0.29850
• 外观性状: Liquid | Clear tan-gold
• 储存条件: 室温

生物活性

• 描述: Sodium Nitroprusside是血管舒张剂,能促使NO释放于血液中。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Wink, D.A., et al., The effect of various nitric oxide-donor agents on hydrogen peroxide-mediated toxicity: a direct correlation between nitric oxide formation and protection. Arch Biochem Biophys, 1996. 331(2): p. 241-8.

  [2]. Garg, U.C. and A. Hassid, Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest, 1989. 83(5): p. 1774-7.

  [3]. Namazi, H., Sodium nitroprusside as a nitric oxide donor in a rat intestinal ischemia reperfusion model: a novel molecular mechanism. Clinics (Sao Paulo), 2008. 63(3): p. 405.

MSDS

Name: Sodium Nitroprusside Material Safety Data Sheet Synonym: Disodium nitrosylpentacyanoferrate; nipride; nitroprussidnatrium;sodium nitroprussat CAS: 14402-89-2 Section 1 - Chemical Product MSDS Name:Sodium Nitroprusside Material Safety Data Sheet Synonym:Disodium nitrosylpentacyanoferrate; nipride; nitroprussidnatrium;sodium nitroprussat Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 14402-89-2 Sodium nitroprusside 100 238-373-9 Hazard Symbols: T+ Risk Phrases: 28 36 Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Very toxic if swallowed. Irritating to eyes.Toxic. Potential Health Effects Eye: May cause eye irritation. Skin: May cause skin irritation. Ingestion: Harmful if swallowed. May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated. Inhalation: Dust is irritating to the respiratory tract. May cause cardiac abnormalities. Chronic: No information found. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower lids. Get medical aid. Skin: Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Ingestion: If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid immediately. Inhalation: Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Notes to Physician: None Antidote: None reported Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing Media: For small fires, use dry chemical, carbon dioxide, water spray or alcohol-resistant foam. Autoignition Temperature: Not applicable. Flash Point: Not applicable. NFPA Rating: Not published. Explosion Limits, Lower: Not available. Upper: Not available. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Wash hands before eating. Use only in a well ventilated area. Minimize dust generation and accumulation. Avoid ingestion and inhalation. Storage: Store in a cool, dry place. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits. Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133. Skin: Wear appropriate gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin. Respirators: Follow the OSHA respirator regulations found in 29CFR 1910.134. Always use a NIOSH-approved respirator when necessary. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Solid Appearance: clear dark red Odor: Not available. pH: Not available. Vapor Pressure: Not applicable. Vapor Density: Not available. Evaporation Rate: Not applicable. Viscosity: Not applicable. Boiling Point: Not available. Freezing/Melting Point: Not available. Decomposition Temperature: Not available. Solubility: 40% @ 20 C Specific Gravity/Density: 1.72 Molecular Formula: C5FeN6Na2O Molecular Weight: 261.8662 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Dust generation. Incompatibilities with Other Materials: Strong oxidizing agents. Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide, toxic fumes of sodium oxide. Hazardous Polymerization: Has not been reported. Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 14402-89-2: LJ8750000 LD50/LC50: CAS# 14402-89-2: Oral, mouse: LD50 = 61 mg/kg; Oral, rabbit: LD50 = 34 mg/kg; Oral, rat: LD50 = 99 mg/kg. Carcinogenicity: Sodium nitroprusside - Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA. Other: See actual entry in RTECS for complete information. Section 12 - ECOLOGICAL INFORMATION For further information, contact Fisher Scientific. Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION CDG/CPL Shipping Name: TOXIC SOLID, INORGANIC, NOS (Sodium nitroprusside) Hazard Class: 6.1 UN Number: 3288 Packing Group: II IMO No information available. IATA No information available. RID/ADR No information available. Canadian TDG Shipping Name: POISONOUS SOLIDS NOS (SODIUM NITROPRUSSIDE) Hazard Class: 6.1(9.2) UN Number: UN2811 Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: T+ Risk Phrases: R 28 Very toxic if swallowed. R 36 Irritating to eyes. Safety Phrases: S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 45 In case of accident of if you feel unwell, seek medical advice immediately (show the label where possible). WGK (Water Danger/Protection) CAS# 14402-89-2: Canada CAS# 14402-89-2 is listed on Canada's DSL/NDSL List. This product has a WHMIS classification of D1B, D2B. CAS# 14402-89-2 is not listed on Canada's Ingredient Disclosure List. Exposure Limits US FEDERAL TSCA CAS# 14402-89-2 is listed on the TSCA inventory. SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : LJ8750000 CHEMICAL NAME : Ferrate(2-), pentacyanonitrosyl-, disodium CAS REGISTRY NUMBER : 14402-89-2 LAST UPDATED : 199701 DATA ITEMS CITED : 22 MOLECULAR FORMULA : C5-Fe-N6-O.2Na MOLECULAR WEIGHT : 261.94 WISWESSER LINE NOTATION : NA2 FE-CN5-NO HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Human - woman DOSE/DURATION : 12500 ug/kg/6D-C TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - hallucinations, distorted perceptions Behavioral - toxic psychosis REFERENCE : JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982- Volume(issue)/page/year: 19,475,1982 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Human DOSE/DURATION : 3360 ug/kg/14H-C TOXIC EFFECTS : Behavioral - toxic psychosis Gastrointestinal - nausea or vomiting Nutritional and Gross Metabolic - metabolic acidosis REFERENCE : AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927- Volume(issue)/page/year: 104,895,1986 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Human - man DOSE/DURATION : 29 mg/kg/1W-I TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Cardiac - pulse rate Gastrointestinal - nausea or vomiting REFERENCE : SMJOAV Southern Medical Journal. (Southern Medical Assoc., POB 2446, Birmingham, AL 35205) V.1- 1908- Volume(issue)/page/year: 77,1035,1984 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Human DOSE/DURATION : 10 mg/kg TOXIC EFFECTS : Cardiac - change in rate Cardiac - other changes Vascular - BP elevation not characterized in autonomic section REFERENCE : CANJAE Canadian Anaesthetists' Society Journal. (Toronto, Ont., Canada) V.1-33, 1954-86. Volume(issue)/page/year: 22,547,1975 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Human - woman DOSE/DURATION : 5 ug/kg/5M-C TOXIC EFFECTS : Brain and Coverings - increased intracranial pressure REFERENCE : JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 246,2679,1981 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Human - woman DOSE/DURATION : 23 mg/kg TOXIC EFFECTS : Behavioral - general anesthetic Cardiac - change in rate Nutritional and Gross Metabolic - metabolic acidosis REFERENCE : ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1940- Volume(issue)/page/year: 49,428,1978 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 99 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 24,308,1974 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 9400 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 24,308,1974 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 6286 ug/kg TOXIC EFFECTS : Blood - other changes REFERENCE : TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 1,92,1981 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 61 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 24,308,1974 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 9400 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 24,308,1974 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 20800 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 24,308,1974 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 34 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 1,92,1981 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 4191 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 1,92,1981 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous DOSE : 909 ng/kg SEX/DURATION : female 20 week(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetal death REFERENCE : AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920- Volume(issue)/page/year: 139,708,1981 *** REVIEWS *** TOXICOLOGY REVIEW PGMJAO Postgraduate Medical Journal. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1925- Volume(issue)/page/year: 50,576,1974 TOXICOLOGY REVIEW ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1940- Volume(issue)/page/year: 45,340,1976 TOXICOLOGY REVIEW DICPBB Drug Intelligence and Clinical Pharmacy. (POB 42435, Cincinnati, OH 45242) V.3- 1969- Volume(issue)/page/year: 9,361,1975 TOXICOLOGY REVIEW FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 35,69,1976 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83380 No. of Facilities: 698 (estimated) No. of Industries: 3 No. of Occupations: 7 No. of Employees: 5099 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83380 No. of Facilities: 2106 (estimated) No. of Industries: 5 No. of Occupations: 18 No. of Employees: 127801 (estimated) No. of Female Employees: 116407 (estimated)

安全

• 危害码 (欧洲): T: Toxic;
• 风险声明 (欧洲): 25
• 安全声明 (欧洲): 45
• 危险品运输编码: UN 3288 6.1/PG 3
• WGK德国: 3
• RTECS号: LJ8925000
• 包装等级: III
• 危险类别: 6.1(b)