14464-46-1

• 常用中文名：白炭黑
• 常用英文名：disilicic acid
• CAS号：14464-46-1
• 分子式：O₂Si
• 分子量：60.08
• 相关类别： 无机化工 氧化物和过氧化物 非金属氧化物和过氧化物
• 发布时间：2018-06-20 10:10:29
• 更新时间：2026-07-01 16:54:25
• 克里斯托镁石可用作赋形剂,如崩解剂、防粘剂、增粘剂、悬浮剂、增稠剂、消泡剂。药用辅料,或称药用辅料,是指除药物成分外,在制药过程中使用的其他化学物质。药用辅料一般是指药物制剂中的非活性成分,可以提高药物制剂的稳定性、溶解性和加工性。药用赋形剂还影响共同给药药物的吸收、分布、代谢和消除(ADME)过程[1]。

名称

• 中文名: 方石英
• 英文名: silica
• 中文别名: 白硅石; 白炭黑/沉淀二氧化硅; 气象法白炭黑; 罗恩 白炭黑 R096490; (药用辅料)二氧化硅; 二氧化硅(微粉硅胶); 色酚 AS/AS-PH/AS-BS/AS-OL/AS-BO/ AS-VL/AS-IRG/AS-G/AS-E/AS-D/AS-P/AS-RL/AS-SW/AS-SG; iHeir-H系列防霉干燥剂; SILICA 白炭黑; 微分硅胶; 超细活性白炭黑; 矽膠; 药用辅料二氧化硅0元送标准 邦凯直销 CDE登记号:F20220000464; 药用辅料二氧化硅0元送标准标准标准可以定制指标 邦凯直销 CDE登记号:F20220000464; 白硅石,方英石,方石英; 罗恩 白炭黑 R017178; 方石英/二氯化硅 600目的; 白炭黑 气相+沉淀; 方英石; 方石英/二氯化硅600目; 白炭黑2000目; 医药级二氧化硅; 二氧化硅(沉淀法)
• 英文别名: SILICA GEL 60GF254 (TYPE60); SILICA GEL 60-C18; SILICA GEL 60HF254 (TYPE60); SILICIC ANHYDRIDE; SILICA GEL 60H (TYPE60); MFCD00011232; 1,3-Dioxodisiloxane-1,3-diol; calcineddiatomaceouseth; silica,cristobalite; alpha-crystobalite; SILICA GEL DESICCANT; SILICA, ANALYTICAL STANDD; SILICA GEL 60; SILICA GEL-BEADS ORANGE; EINECS 262-373-8; SILEX; SILICA F-TLC; SILICA GEL 60 SILANIZED; silice,cristobalite; SILICA GEL 60G (TYPE60); metacristobalite; SILICA GEL 60 GF254; Hydrogen [hydroxy(oxo)silyl]silicate; Silicic acid (HSiO), mono(hydroxyoxosilyl) ester; SILICA GEL (DAVISIL) SORBENT; w006; silica,crystalline-cristobalite; SIO2/SI; SILICA GEL 22; SILICA GEL DESICCANT, ORANGE GEL; SILICA GEL 60 H; SILICA GEL DESICCANT, BLUE GEL; SILICA GEL 60 HF254; SILICON OXIDE; SILICA GEL 30; SILICA GEL; POLYGOPR(R); wgl300; SILICA; SILICA GEL BEADS; SILICA GEL 7; SIO2

物化性质

• 密度: 2.6 g/mL at 25ºC(lit.)
• 沸点: 4046 deg F
• 熔点: 3110 deg FºC
• 分子式: O₂Si
• 分子量: 60.08
• 精确质量: 137.944077
• PSA: 34.14000
• 外观性状: 淡灰色固体
• 折射率: n20/D 1.544(lit.)
• 储存条件:

  贮存在通风、干燥处、避免受潮和污染。装卸时要轻拿轻放，防止包装破损。失火时，可用水和各种灭火器扑救。

• 更多:

  1.性状：白色无定形微细粉末

  2.熔点（ºC）：1750

  3.溶解性：不溶于水及酸。高温不分解。有吸水性、多孔性。

生物活性

• 描述: 克里斯托镁石可用作赋形剂,如崩解剂、防粘剂、增粘剂、悬浮剂、增稠剂、消泡剂。药用辅料,或称药用辅料,是指除药物成分外,在制药过程中使用的其他化学物质。药用辅料一般是指药物制剂中的非活性成分,可以提高药物制剂的稳定性、溶解性和加工性。药用赋形剂还影响共同给药药物的吸收、分布、代谢和消除(ADME)过程[1]。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : VV7325000 CHEMICAL NAME : Silica, crystalline - cristobalite CAS REGISTRY NUMBER : 14464-46-1 LAST UPDATED : 199712 DATA ITEMS CITED : 38 MOLECULAR FORMULA : O2-Si MOLECULAR WEIGHT : 60.09 WISWESSER LINE NOTATION : SI O2 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Human DOSE/DURATION : 16 mppcf/8H/17.9Y-I TOXIC EFFECTS : Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis) Lungs, Thorax, or Respiration - cough Lungs, Thorax, or Respiration - dyspnea REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB246-697 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intratracheal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis) REFERENCE : BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944- Volume(issue)/page/year: 10,9,1953 ** TUMORIGENIC DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intrapleural SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 90 mg/kg TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Blood - lymphoma, including Hodgkin's disease REFERENCE : JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 57,509,1976 TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Intrapleural SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 100 mg/kg REFERENCE : BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 41,908,1980 *** REVIEWS *** ACGIH TLV-TWA 0.05 mg/m3, respirable dust DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 42,39,1987 IARC Cancer Revew:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 68,41,1997 IARC Cancer Review:Human Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 42,39,1987 IARC Cancer Revew:Human Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 68,41,1997 IARC Cancer Revew:Group 1 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 68,41,1997 TOXICOLOGY REVIEW ANAEA3 Annals of Allergy. (American College of Allergists, POB 20671, Bloomington, MN 55420) V.1- 1943- Volume(issue)/page/year: 35,165,1975 TOXICOLOGY REVIEW 31BYAP "Experimental Lung Cancer: Carcinogenesis and Bioassays, International Symposium, 1974," Karbe, E., and J.F. Park, eds., Springer-Verlag New York, Inc., 1974 Volume(issue)/page/year: -,93,1974 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-respirable dust in air:TWA 10 mg/m3/2(% resp. SiO2+2) DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8. Volume(issue)/page/year: 3,33,1973 MSHA STANDARD-total dust in air:TWA 30 mg/m3/2(% SiO2+3) DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8. Volume(issue)/page/year: 3,33,1973 OSHA PEL (Gen Indu):8H TWA 5 mg/m3/(% resp SiO2+2) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 5 mg/m3/(% resp SiO2+2) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 20 mppcf/(%SiO2+5) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-BELGIUM:TWA 0.05 mg/m3 JAN 1993 OEL-DENMARK:TWA 0.05 mg/m3 JAN 1993 OEL-DENMARK:TWA 0.15 mg/m3 (total dust) JAN 1993 OEL-FINLAND:TWA 0.1 mg/m3 JAN 1993 OEL-GERMANY:TWA 0.15 mg/m3 JAN 1993 OEL-RUSSIA:STEL 1 mg/m3 (total dust) JAN 1993 OEL-SWEDEN:TWA 0.05 mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 0.15 mg/m3 JAN 1993 OEL-THAILAND:TWA 10 mg/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 0.05 mg/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 0.15 mg/m3 (total dust) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO SILICA, cryst. cristobalite-air:10H CA TWA 0.05 mg/m3 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - T0624 No. of Facilities: 2072 (estimated) No. of Industries: 33 No. of Occupations: 43 No. of Employees: 31369 (estimated) No. of Female Employees: 2228 (estimated)

安全

• 危害码 (欧洲): Xn,T
• 风险声明 (欧洲): 48/20
• 安全声明 (欧洲): 22
• WGK德国: 3
• RTECS号: VV7340000

制备

硝酸法　水玻璃溶液和硝酸反应生成二氧化硅，经漂洗、酸洗、去离子水漂洗、脱水制得电子级二氧化硅。反应式如下：