158984-84-0

• 常用中文名：6-三氟甲基磺酰基氧基-1,2,3,4-四氢-异喹啉-2-羧酸叔丁酯
• 常用英文名：tert-butyl 6-(trifluoromethylsulfonyloxy)-3,4-dihydro-1H-isoquinoline-2-carboxylate
• CAS号：158984-84-0
• 分子式：C₁₅H₁₈F₃NO₅S
• 分子量：381.36700
• 发布时间：2018-12-01 18:42:02
• 更新时间：2024-01-09 16:13:55

名称

• 中文名: 6-三氟甲基磺酰基氧基-1,2,3,4-四氢-异喹啉-2-羧酸叔丁酯
• 英文名: tert-butyl 6-(trifluoromethylsulfonyloxy)-3,4-dihydro-1H-isoquinoline-2-carboxylate
• 英文别名: TERT-BUTYL 6-(TRIFLUOROMETHYLSULFONYLOXY)-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE; 6-trifluoromethanesulfonyloxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester; 1,1-dimethylethyl 6-{[(trifluoromethyl)sulfonyl]oxy}-3,4-dihydro-2(1H)-isoquinolinecarboxylate; tert-butyl 6-trifluoromethylsulphonyloxy-1,2,3,4-tetrahydro-isoquinoline-2-carboxylate; tert-butyl 6-(trifluoromethanesulphonyloxy)-3,4-dihydro-1H-isoquinoline-2-carboxylate; 6-(trifluoromethylsulfonyloxy)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester; tert-butyl 6-(trifluoro-methanesulfonyl)oxy-3,4-dihydroisoquinoline-2(1H)-carboxylate; 2-tert-butoxycarbonyl-6-trifluoromethanesulfonyloxy-1,2,3,4-tetrahydroisoquinoline

物化性质

• 分子式: C₁₅H₁₈F₃NO₅S
• 分子量: 381.36700
• 精确质量: 381.08600
• PSA: 81.29000
• LogP: 4.22690

合成路线

358-23-6 158984-83-9 ~87% 158984-84-0

文献：Haginoya, Noriyasu; Kobayashi, Syozo; Komoriya, Satoshi; Yoshino, Toshiharu; Suzuki, Makoto; Shimada, Takashi; Watanabe, Kengo; Hirokawa, Yumiko; Furugori, Taketoshi; Nagahara, Takayasu Journal of Medicinal Chemistry, 2004 , vol. 47, # 21 p. 5167 - 5182

158984-83-9 ~% 158984-84-0

文献：Smithkline Beecham Corporation Patent: US2011/124559 A1, 2011 ;

37595-74-7 158984-83-9 ~98% 158984-84-0

文献：Horiuchi, Takao; Nagata, Motoko; Kitagawa, Mayumi; Akahane, Kouichi; Uoto, Kouichi Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 23 p. 7850 - 7860

24424-99-5 ~% 158984-84-0

文献：Chekler, Eugene L. Piatnitski; Unwalla, Rayomond; Khan, Taukeer A.; Tangirala, Raghuram S.; Johnson, Mark; St. Andre, Michael; Anderson, James T.; Kenney, Thomas; Chiparri, Sue; McNally, Chris; Kilbourne, Edward; Thompson, Catherine; Nagpal, Sunil; Weber, Gregory; Schelling, Scott; Owens, Jane; Morris, Carl A.; Powell, Dennis; Verhoest, Patrick R.; Gilbert, Adam M. Journal of Medicinal Chemistry, 2014 , vol. 57, # 6 p. 2462 - 2471

63905-73-7 ~% 158984-84-0

文献：Haginoya, Noriyasu; Kobayashi, Syozo; Komoriya, Satoshi; Yoshino, Toshiharu; Suzuki, Makoto; Shimada, Takashi; Watanabe, Kengo; Hirokawa, Yumiko; Furugori, Taketoshi; Nagahara, Takayasu Journal of Medicinal Chemistry, 2004 , vol. 47, # 21 p. 5167 - 5182

59839-23-5 ~% 158984-84-0

文献：Chekler, Eugene L. Piatnitski; Unwalla, Rayomond; Khan, Taukeer A.; Tangirala, Raghuram S.; Johnson, Mark; St. Andre, Michael; Anderson, James T.; Kenney, Thomas; Chiparri, Sue; McNally, Chris; Kilbourne, Edward; Thompson, Catherine; Nagpal, Sunil; Weber, Gregory; Schelling, Scott; Owens, Jane; Morris, Carl A.; Powell, Dennis; Verhoest, Patrick R.; Gilbert, Adam M. Journal of Medicinal Chemistry, 2014 , vol. 57, # 6 p. 2462 - 2471

22246-12-4 ~% 158984-84-0

文献：Smithkline Beecham Corporation Patent: US2011/124559 A1, 2011 ;

上下游产品

上游产品  7
358-23-6 158984-83-9 37595-74-7 24424-99-5
63905-73-7 59839-23-5 22246-12-4
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