63905-73-7

• 常用中文名：1,2,3,4-四氢异喹啉-6-醇盐酸盐
• 常用英文名：1,2,3,4-Tetrahydro-isoquinolin-6-ol HCl
• CAS号：63905-73-7
• 分子式：C₉H₁₂ClNO
• 分子量：185.651
• 发布时间：2018-12-24 17:29:20
• 更新时间：2024-01-09 19:05:34

名称

• 中文名: 1,2,3,4-四氢异喹啉-6-醇盐酸盐
• 英文名: 1,2,3,4-tetrahydroisoquinolin-6-ol,hydrochloride
• 英文别名: 1,2,3,4-tetrahydroisoquinolin-6-ol Hydrochloride; 1,2,3,4-Tetrahydro-isoquinolin-6-ol HCl; 6-Isoquinolinol, 1,2,3,4-tetrahydro-, hydrochloride (1:1); 1,2,3,4-Tetrahydro-6-isoquinolinol hydrochloride (1:1)

物化性质

• 沸点: 313.5ºC at 760mmHg
• 分子式: C₉H₁₂ClNO
• 分子量: 185.651
• 闪点: 169.5ºC
• 精确质量: 185.060745
• PSA: 32.26000
• LogP: 2.16870

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : NX1400000 CHEMICAL NAME : Isoquinoline, 6-hydroxy-1,2,3,4-tetrahydro-, hydrochloride CAS REGISTRY NUMBER : 63905-73-7 LAST UPDATED : 199009 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C9-H11-N-O.Cl-H MOLECULAR WEIGHT : 185.67 WISWESSER LINE NOTATION : T66 CMT&J HQ &GH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Parenteral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 465 mg/kg TOXIC EFFECTS : Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 62,165,1938

安全

• 海关编码: 2933499090

合成路线

42923-77-3 ~88% 63905-73-7

文献：Daiichi Pharmaceutical Co., Ltd. Patent: US6525042 B1, 2003 ;

50-00-0 3458-98-8 ~% 63905-73-7

文献：ONO PHARMACEUTICAL CO., LTD. Patent: EP1760071 A1, 2007 ; Location in patent: Page/Page column 64 ;

上下游产品

上游产品  3
42923-77-3 50-00-0 3458-98-8
下游产品  5
158984-84-0 170097-66-2 14446-24-3 158984-83-9
170097-67-3

海关

海关编码	2933499090
中文概述	2933499090. 其他含喹琳或异喹啉环系的化合物〔但未进一步稠合的〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%