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426219-18-3生产厂家

426219-18-3价格

426219-18-3

426219-18-3结构式
426219-18-3结构式
  • 常用中文名:6-(6,7-二氢-7-羟基-5H-吡咯并[1,2-c]咪唑-7-基)-n-甲基-2-萘羧酰胺
  • 常用英文名:TAK-700 (Orteronel)
  • CAS号:426219-18-3
  • 分子式:C18H17N3O2
  • 分子量:307.346
  • 相关类别: 生物化工 抑制剂 代谢(Metabolism) P450 (e.g. CYP17) 抑制剂
  • 发布时间:2018-12-27 17:05:38
  • 更新时间:2024-01-03 11:49:41
  • Orteronel (racemic) is a mixture of S-Orteronel and R-Orteronel isomers. Orteronel, aslo known as TAK-700, is an orally bioavailable non-steroidal androgen synthesis inhibitor of steroid 17alpha-monooxygenase (17,20 lyase) with potential antiandrogen activity. TAK-700 binds to and inhibits the steroid 17alpha-monooxygenase in both the testes and adrenal glands, thereby inhibiting androgen production. This may decrease androgen-dependent growth signaling and may inhibit cell proliferation of androgen-dependent tumor cells.

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中文名 6-(6,7-二氢-7-羟基-5H-吡咯并[1,2-c]咪唑-7-基)-n-甲基-2-萘羧酰胺
英文名 6-(7-hydroxy-5,6-dihydropyrrolo[1,2-c]imidazol-7-yl)-N-methylnaphthalene-2-carboxamide
英文别名 6-(7-Hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-yl)-N-methyl-2-naphthamide
S1195_Selleck
2-Naphthalenecarboxamide, 6-(6,7-dihydro-7-hydroxy-5H-pyrrolo[1,2-c]imidazol-7-yl)-N-methyl-
TAK700
(S)-6-(7-hydroxy-6,7-dihydro-5H-pyrrolo[1,2-e]imidazol-7-yl)-N-methyl-2-naphthamide
TAK-700 (Orteronel)
6-[7-hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-yl]-N-methyl-2-naphthamide
Orteronel
TAK-700
密度 1.4±0.1 g/cm3
沸点 685.1±45.0 °C at 760 mmHg
分子式 C18H17N3O2
分子量 307.346
闪点 368.2±28.7 °C
精确质量 307.132080
PSA 67.15000
LogP -0.13
外观性状 粉末
蒸汽压 0.0±2.2 mmHg at 25°C
折射率 1.695
储存条件 -20℃