6-(6,7-二氢-7-羟基-5H-吡咯并[1,2-c]咪唑-7-基)-n-甲基-2-萘羧酰胺

• 常用名: 6-(6,7-二氢-7-羟基-5H-吡咯并[1,2-c]咪唑-7-基)-n-甲基-2-萘羧酰胺
• 英文名: TAK-700 (Orteronel)
• CAS号: 426219-18-3
• 分子量: 307.346
• 密度: 1.4±0.1 g/cm3
• 沸点: 685.1±45.0 °C at 760 mmHg
• 分子式: C₁₈H₁₇N₃O₂
• 熔点: N/A
• 闪点: 368.2±28.7 °C

用途

Orteronel (racemic) is a mixture of S-Orteronel and R-Orteronel isomers. Orteronel, aslo known as TAK-700, is an orally bioavailable non-steroidal androgen synthesis inhibitor of steroid 17alpha-monooxygenase (17,20 lyase) with potential antiandrogen activity. TAK-700 binds to and inhibits the steroid 17alpha-monooxygenase in both the testes and adrenal glands, thereby inhibiting androgen production. This may decrease androgen-dependent growth signaling and may inhibit cell proliferation of androgen-dependent tumor cells.

名称

• 中文名: 6-(6,7-二氢-7-羟基-5H-吡咯并[1,2-c]咪唑-7-基)-n-甲基-2-萘羧酰胺
• 英文名: 6-(7-hydroxy-5,6-dihydropyrrolo[1,2-c]imidazol-7-yl)-N-methylnaphthalene-2-carboxamide

物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 685.1±45.0 °C at 760 mmHg
• 分子式: C₁₈H₁₇N₃O₂
• 分子量: 307.346
• 闪点: 368.2±28.7 °C
• 精确质量: 307.132080
• PSA: 67.15000
• LogP: -0.13
• 外观性状: 粉末
• 蒸汽压: 0.0±2.2 mmHg at 25°C
• 折射率: 1.695
• 储存条件: -20℃

靶点实验

查看更多实验

实验名称：Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro... 来源：NCGC 靶标：N/A External Id：SERCaMPGLuc-p1-antagonist

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：Primary qHTS for Identification of Small Molecule Activators of Huntingtin-Antisense ... 来源：NCGC External Id：huntington-HTTAS8-p1-FF-overN

实验名称：Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry 来源：NCGC 靶标：N/A External Id：TRND-SARS-CoV-2-cytotox-48hr

实验名称：Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry 来源：NCGC External Id：TRND-SARS-CoV-2-PP

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-keats_OPM1-m4-1

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-OC1MY5-m4-1

实验名称：Inhibition of 17,20-lyase of recombinant human CYP17A1 using [1,2-3H]-17a-hydroxypreg... 来源：ChEMBL 靶标：Steroid 17-alpha-hydroxylase/17,20 lyase External Id：CHEMBL1926383

实验名称：Inhibition of 17,20-lyase activity of Sprague-Dawley rat testicular microsomal CYP17A... 来源：ChEMBL 靶标：Steroid 17-alpha-hydroxylase/17,20 lyase External Id：CHEMBL1926382

共110条，当前第1页，共11页

1

2

3

4

5

英文别名

• 6-(7-Hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-yl)-N-methyl-2-naphthamide
• S1195_Selleck
• TAK700
• (S)-6-(7-hydroxy-6,7-dihydro-5H-pyrrolo[1,2-e]imidazol-7-yl)-N-methyl-2-naphthamide
• TAK-700 (Orteronel)
• 6-[7-hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-yl]-N-methyl-2-naphthamide
• Orteronel
• TAK-700