10106-41-9

• 常用中文名：17,21-二羟基-16α-甲基孕烯-1,4,9(11)-三烯-3,20-二酮-21-乙酸酯
• 常用英文名：17-alpha,21-Dihydroxy-16-alpha-Methylpregna-1,4,9(11)-Triene-3,20-Dione 21-Acetate
• CAS号：10106-41-9
• 分子式：C₂₄H₃₀O₅
• 分子量：398.49200
• 发布时间：2018-12-14 17:38:56
• 更新时间：2026-07-08 18:48:10
• 地塞米松醋酸酯的中间体。

名称

• 中文名: 17-alpha,21-二羟基-16-alpha-甲基孕甾-1,4,9(11)-三烯-3,20-二酮21-乙酸酯
• 英文名: (16α)-17-Hydroxy-16-methyl-3,20-dioxopregna-1,4,9(11)-trien-21-yl acetate
• 中文别名: 21-二羟基-16&ALPHA-甲基孕甾-1,4,9-三烯-3,20-二酮-21-醋酸酯; 地塞米松杂质杂质H; 地塞米松杂质H(醋酸地塞米松杂质H); 地塞米松杂质H; 地塞米松杂质31; 16Α-甲基孕甾-1,4,9-三烯-17Α,21-二醇-3,20-二酮-21-醋酸酯; 醋酸地塞米松杂质8; 2-(((8S,10S,13S,14S,16R,17R)-17-羟基-10,13,16-三甲基-3-氧代-6,7,8,10,12,13,14,15,16 ,17-十氢-3H-环戊[a]菲蒽-17-基)-2-氧代乙酸乙酯(地塞米松杂质); 2-((8S,10S,13S,14S,16R,17R)-17-羟基-10,13,16-三甲基-3-氧代-6,7,8,10,12,13,14,15,16,17-十氢-3H-环戊[A]菲-17-基)-2-氧代乙酸乙酯; 地塞米松杂质8(地塞米松杂质H); 醋酸地塞米松杂质8(醋酸地塞米松杂质H); 醋酸地塞米松杂质H; 地塞米松磷酸钠杂质H
• 英文别名: (16α)-21-(Acetyloxy)-17-hydroxy-16-methylpregna-1,4,9-triene-3,20-dione; 17,21-Dihydroxy-16-methylpregna-1,4,9-triene-3,20-dione 21-acetate; 2-((8S,10S,13S,14S,16R,17R)-17-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,10,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate; 2-((8S,10S,13S,14S,16R,17R)-17; 2-((10S,13S,14S,16R,17R)-17-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,10,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate; 2-((8S,10S,13S,14S,16R,17R)-17-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,10,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate (Dexamethasone Impurity）; Dexamethasone impurity H; Dexamethasone Acetate Impurity 8; 17-alpha,21-Dihydroxy-16-a-methylpregna-1,4,9-triene-3,20-dione 21-acetate; 17,21-Dihydroxy-16a-methylpregna-1,4,9-triene-3,20-dione 21-Acetate; 21-Acetoxy-17-hydroxy-16α-methylpregna-1,4,9-triene-3,20-dione; Pregna-1,4,9-triene-3,20-dione, 21-(acetyloxy)-17-hydroxy-16-methyl-, (16α); Dexamethasone Acetate Impurity 8（Dexamethasone Acetate Impurity H）; "17,21-Dihydroxy-16-β-methylpregna-1,4,9-triene-3,20-dione 21-Acetate"; Pregna-1,4,9-triene-3,20-dione,21-(acetyloxy)-17-hydroxy-16-methyl-, (16a); Dexamethasone Impurity 8(Dexamethasone Impurity H); 17-HYDROXY-16-ALPHA-METHYL-3,20-DIOXOPREGNA-1,4,9-TRIEN-21-YL ACETATE; Pregna-1,4,9-triene-3,20-dione, 17,21-dihydroxy-16.alpha.-methyl-, 21-acetate; Dexamethasone Acetate Impurity H; (16α)-17-Hydroxy-16-methyl-3,20-dioxopregna-1,4,9-trien-21-yl acetate; Dexamethasone impurity 2/Dexamethasone Impurity H; 21-Acetyloxy-17-hydroxy-16-methylpregna-1,4,9-triene-3,20-dione; 17α, 21-dihydroxy-16α-methyl-1, 4 ,9-pregnatriene-3, 20-dione 21-acetate; 17,21-Dihydroxy-16α-Methylpregna-1,4,9(11)-triene-3,20-dione 21-Acetate; 17,21-Dihydroxy-16α-methylpregna-1,4,9-triene-3,20-dione 21-Acetate; Dexamethasone Imp H; EINECS 233-290-4; 17-hydroxy-16α-methyl-3,20-dioxopregna-1,4,9-trien-21-yl acetate; 17,21-Dihydroxy-16Alpha-methylpregna-1,4,9-triene-3,20-dione 21-Acetate; Pregnatriene acetate; 17-alpha,21-dihydroxy-16-alpha-methylpregna-1,4,9-triene-3,20-dione 21-acetate; 17,21-Dihydroxy-16Alpha-methylpregna-1,4,9(11)-triene-3,20-dione 21-Acetate; Dexamethasone Impurity H(Dexamethasone Acetate Impurity H)

物化性质

• 密度: 1.22g/cm3
• 沸点: 560ºC at 760mmHg
• 熔点: 208℃
• 分子式: C₂₄H₃₀O₅
• 分子量: 398.49200
• 闪点: 189.6ºC
• 精确质量: 398.20900
• PSA: 80.67000
• LogP: 3.32370
• 蒸汽压: 7.12E-15mmHg at 25°C
• 折射率: 1.58

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制备

可用3β-羟基孕甾-5,16-二烯-20-酮-3-醋酸酯（即妊娠双烯醇酮醋酸酯）经（16-位双键亚硝基甲基脲）加成并消除，生成3β-羟基-16β-甲基孕甾-5,16-二烯-20-酮，然后[16（17）-位]环氧化、乙酰化并环氧基开环（形成17α-羟基及15-位双键）、进而（15-位双键）催化氢化、水解（脱3-位乙酰基）、（3-位羟基）氧化（双键转至4-位）、（21-位）碘化、（21-位碘以乙酰氧基）置换、生物氧化（引入11-位羟基）（11-位羟基）磺酰化并消除[形成9（11）-双键]制得该品。