82023-29-8

• 常用中文名：2,4(1H,3H)-Pyrimidinedione, 3-(1,3-dihydro-3-oxo-1-isobenzofuranyl)-5- fluoro-
• 常用英文名：2,4(1H,3H)-Pyrimidinedione, 3-(1,3-dihydro-3-oxo-1-isobenzofuranyl)-5- fluoro-
• CAS号：82023-29-8
• 分子式：C₁₂H₇FN₂O₄
• 分子量：262.19300
• 发布时间：2018-06-21 18:35:14
• 更新时间：2024-01-14 10:39:27

名称

• 英文名: 5-fluoro-3-(3-oxo-1H-2-benzofuran-1-yl)-1H-pyrimidine-2,4-dione
• 英文别名: 3-Pfu; N3-phthalidyl-5-fluorouracil; Uracil,5-fluoro-3-phthalidyl; 5-Fluoro-3-phthalidyl-uracil

物化性质

• 密度: 1.62g/cm3
• 分子式: C₁₂H₇FN₂O₄
• 分子量: 262.19300
• 精确质量: 262.03900
• PSA: 81.42000
• LogP: 0.80530
• 折射率: 1.664

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : YR0430000 CHEMICAL NAME : Uracil, 5-fluoro-3-phthalidyl- CAS REGISTRY NUMBER : 82023-29-8 LAST UPDATED : 199612 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C12-H7-F-N2-O4 MOLECULAR WEIGHT : 262.21 WISWESSER LINE NOTATION : T56 BVO DHJ D- CT6MVNVJ EF HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2500 mg/kg TOXIC EFFECTS : Behavioral - changes in motor activity (specific assay) Behavioral - muscle weakness Nutritional and Gross Metabolic - body temperature decrease REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 25,1219,1982

合成路线

82033-51-0 ~82% 82023-29-8

文献：Kamata; Haga; Matsui; Nagata Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 8 p. 3160 - 3175

51-21-8 6940-49-4 ~% 82023-29-8

文献：Grelan Pharmaceutical Co., Ltd. Patent: US4528372 A1, 1985 ;

82104-77-6 ~48% 82023-29-8

文献：Kamata; Haga; Matsui; Nagata Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 8 p. 3160 - 3175

90162-91-7 ~94% 82023-29-8

文献：Ozaki, Shoichiro; Watanabe, Yutaka; Fujisawa, Hiroshi; Hoshiko, Tomonori Heterocycles, 1984 , vol. 22, # 3 p. 527 - 530

104861-76-9 ~% 82023-29-8

文献：Kamata; Haga; Matsui; Nagata Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 8 p. 3160 - 3175

6940-49-4 ~% 82023-29-8

文献：Kametani, Tetsuji; Kigasawa, Kazuo; Hiiragi, Mineharu; Wakisaka, Kikuo; Nakazato, Kikuo; et al. Journal of Medicinal Chemistry, 1982 , vol. 25, # 10 p. 1219 - 1222