112887-62-4

• 常用中文名：(2S)-2-[[4-[(2-methyl-4-oxo-1H-quinazolin-6-yl)methyl-prop-2-ynylamino]benzoyl]amino]pentanedioic acid
• 常用英文名：(2S)-2-[[4-[(2-methyl-4-oxo-1H-quinazolin-6-yl)methyl-prop-2-ynylamino]benzoyl]amino]pentanedioic acid
• CAS号：112887-62-4
• 分子式：C₂₅H₂₄N₄O₆
• 分子量：476.48100
• 发布时间：2017-01-10 19:16:42
• 更新时间：2026-09-28 17:26:40

名称

• 英文名: (2S)-2-[[4-[(2-methyl-4-oxo-1H-quinazolin-6-yl)methyl-prop-2-ynylamino]benzoyl]amino]pentanedioic acid
• 英文别名: 2-deamino-PDDF; N-[4-[[[(2-Methyl-3,4-dihydro-4-oxoquinazolin)-6-yl]methyl]-2-propynylamino]benzoyl]-L-glutamic acid; N-<4-<N-<(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl>prop-2-ynylamino>benzoyl>-L-glutamic acid; N-<4-<N-<(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl>-N-prop-2-ynylamino>benzoyl>-L-glutamic acid; CB-3819; L-Glutamic acid,N-(4-(((1,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl)-2-propynylamino)benzoyl); 2-desamino-2-methyl-N(10)-propargyl-5,8-dideazafolic acid; CB 3819; N-p-[N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-(prop-2-ynyl)amino]benzoyl-L-glutamic acid; 2-Desamino-2-methyl-10-propagyl-5,8-dideazofolic acid; N-[4-[2-Propynyl[(3,4-dihydro-4-oxo-2-methylquinazolin)-6-ylmethyl]amino]benzoyl]-L-glutamic acid; 2-Desamino-2-methyl-N10-propgyl-5,8-dideazafolic acid; (2S)-2-[4-[N-[(3,4-Dihydro-2-methyl-4-oxoquinazolin)-6-ylmethyl]-N-(2-propynyl)amino]benzoylamino]glutic acid

物化性质

• 密度: 1.33g/cm3
• 分子式: C₂₅H₂₄N₄O₆
• 分子量: 476.48100
• 精确质量: 476.17000
• PSA: 152.95000
• LogP: 2.72230
• 折射率: 1.638

合成路线

76858-72-5 112888-43-4 ~69% 112887-62-4

文献：Patil; Jones; Nair; Galivan; Maley; Kisliuk; Gaumont; Duch; Ferone Journal of Medicinal Chemistry, 1989 , vol. 32, # 6 p. 1284 - 1289

18731-19-6 ~% 112887-62-4

文献：Hughes; Jackman; Oldfield; Smith; Burrows; Marsham; Bishop; Jones; O'Connor; Calvert Journal of Medicinal Chemistry, 1990 , vol. 33, # 11 p. 3060 - 3067

2941-78-8 ~% 112887-62-4

文献：Patil; Jones; Nair; Galivan; Maley; Kisliuk; Gaumont; Duch; Ferone Journal of Medicinal Chemistry, 1989 , vol. 32, # 6 p. 1284 - 1289

67081-68-9 ~% 112887-62-4

文献：Patil; Jones; Nair; Galivan; Maley; Kisliuk; Gaumont; Duch; Ferone Journal of Medicinal Chemistry, 1989 , vol. 32, # 6 p. 1284 - 1289

119820-57-4 ~% 112887-62-4

文献：Patil; Jones; Nair; Galivan; Maley; Kisliuk; Gaumont; Duch; Ferone Journal of Medicinal Chemistry, 1989 , vol. 32, # 6 p. 1284 - 1289

112888-43-4 ~% 112887-62-4

文献：Hughes; Jackman; Oldfield; Smith; Burrows; Marsham; Bishop; Jones; O'Connor; Calvert Journal of Medicinal Chemistry, 1990 , vol. 33, # 11 p. 3060 - 3067

119820-58-5 ~% 112887-62-4

文献：Patil; Jones; Nair; Galivan; Maley; Kisliuk; Gaumont; Duch; Ferone Journal of Medicinal Chemistry, 1989 , vol. 32, # 6 p. 1284 - 1289