(2S)-2-[[4-[(2-methyl-4-oxo-1H-quinazolin-6-yl)methyl-prop-2-ynylamino]benzoyl]amino]pentanedioic acid

• 常用名: (2S)-2-[[4-[(2-methyl-4-oxo-1H-quinazolin-6-yl)methyl-prop-2-ynylamino]benzoyl]amino]pentanedioic acid
• 英文名: (2S)-2-[[4-[(2-methyl-4-oxo-1H-quinazolin-6-yl)methyl-prop-2-ynylamino]benzoyl]amino]pentanedioic acid
• CAS号: 112887-62-4
• 分子量: 476.48100
• 密度: 1.33g/cm3
• 沸点: N/A
• 分子式: C₂₅H₂₄N₄O₆
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: (2S)-2-[[4-[(2-methyl-4-oxo-1H-quinazolin-6-yl)methyl-prop-2-ynylamino]benzoyl]amino]pentanedioic acid

物理化学性质

• 密度: 1.33g/cm3
• 分子式: C₂₅H₂₄N₄O₆
• 分子量: 476.48100
• 精确质量: 476.17000
• PSA: 152.95000
• LogP: 2.72230
• 折射率: 1.638

靶点实验

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实验名称：Relative resistance ratio evaluated for murine tumor L1210:1565 cells with 10% fetal ... 来源：ChEMBL 靶标：L1210 (1565) External Id：CHEMBL704815

实验名称：The compound was tested in vitro for the inhibition of L1210 cell growth in the prese... 来源：ChEMBL 靶标：L1210 External Id：CHEMBL707956

实验名称：Inhibition of cell growth in culture against murine tumor L1210:1565 cell lines 来源：ChEMBL 靶标：L1210 (1565) External Id：CHEMBL704814

实验名称：Concentration required for in vitro inhibition of thymidylate synthase 来源：ChEMBL 靶标：Thymidylate synthase External Id：CHEMBL815670

实验名称：Tested for inhibition of cell growth in culture against murine tumor L1210:RD1694 cel... 来源：ChEMBL 靶标：L1210 (RD1694) External Id：CHEMBL704819

实验名称：Concentration required to inhibit 50% activity of Thymidylate synthase was determined 来源：ChEMBL 靶标：Thymidylate synthase External Id：CHEMBL815669

实验名称：Relative resistance ratio evaluated for murine tumor L1210:RD1694 cells with 10% hors... 来源：ChEMBL 靶标：L1210 (RD1694) External Id：CHEMBL704820

实验名称：The inhibitory activity was determined on L1210 mouse leukemia cell in presence of th... 来源：ChEMBL 靶标：L1210 External Id：CHEMBL707514

实验名称：Solubility in 0.92 M aqueous NaH2PO4 buffer at pH 7.0 and 25 degree C 来源：ChEMBL 靶标：N/A External Id：CHEMBL638271

实验名称：In vitro inhibition against L1210 thymidylate synthase (TS) 来源：ChEMBL 靶标：Thymidylate synthase External Id：CHEMBL815675

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英文别名

• 2-Desamino-2-methyl-10-propagyl-5,8-dideazofolic acid
• 2-desamino-2-methyl-N(10)-propargyl-5,8-dideazafolic acid
• N-p-[N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-(prop-2-ynyl)amino]benzoyl-L-glutamic acid
• N-<4-<N-<(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl>-N-prop-2-ynylamino>benzoyl>-L-glutamic acid
• 2-deamino-PDDF
• CB 3819
• L-Glutamic acid,N-(4-(((1,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl)-2-propynylamino)benzoyl)
• N-<4-<N-<(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl>prop-2-ynylamino>benzoyl>-L-glutamic acid