73-66-5

73-66-5结构式
73-66-5结构式

化源商城直购

英文名 5-(ethoxymethyl)-2-methylpyrimidin-4-amine
英文别名 EINECS 200-802-2
5-Aethoxymethyl-2-methyl-pyrimidin-4-ylamin
5-Ethoxymethyl-2-methylpyrimidin-4-ylamine
4-amino-5-ethoxymethyl-2-methylpyrimidine
4-Amino-2-methyl-5-ethoxymethylpyrimidine
2-Methyl-4-amino-5-<aethoxymethyl>-pyrimidin
2-methyl-4-amino-5-ethoxymethylpyrimidine
密度 1.113g/cm3
沸点 276.4ºC at 760 mmHg
分子式 C8H13N3O
分子量 167.20800
闪点 121ºC
精确质量 167.10600
PSA 61.03000
LogP 1.48490
折射率 1.544

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UV6450000
CHEMICAL NAME :
Pyrimidine, 4-amino-5-(ethoxymethyl)-2-methyl-
CAS REGISTRY NUMBER :
73-66-5
BEILSTEIN REFERENCE NO. :
0139361
LAST UPDATED :
199612
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C8-H13-N3-O
MOLECULAR WEIGHT :
167.24

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1450 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,81,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
239 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,81,1982 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
11 mg/m3/17W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
TNICS* Toxicology of New Industrial Chemical Substances. English translation of TPKVAL. (USSR Academy of Medical Sciences, Meditsina, Moscow, USSR) Volume(issue)/page/year: 13,59,1973 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
11 mg/m3
SEX/DURATION :
male 17 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
REFERENCE :
TNICS* Toxicology of New Industrial Chemical Substances. English translation of TPKVAL. (USSR Academy of Medical Sciences, Meditsina, Moscow, USSR) Volume(issue)/page/year: 13,59,1973 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 1 mg/m3 JAN 1993

海关编码 2933599090

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文献:Cline et al. Journal of the American Chemical Society, 1937 , vol. 59, p. 1052

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文献:Cline et al. Journal of the American Chemical Society, 1937 , vol. 59, p. 1052

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文献:Hoffmann-La Roche Patent: US2480326 , 1946 ;

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文献:Fodor et al. Zhurnal Obshchei Khimii, 1951 , vol. 21, p. 1897,1900; engl. Ausg. S. 2109, 2111 Show Details Takamizawa et al. Yakugaku Zasshi, 1958 , vol. 78, p. 637,642 Chemical and Pharmaceutical Bulletin, 1966 , vol. 14, p. 238 Chem.Abstr., 1958 , p. 18411

~%

73-66-5结构式

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文献:Fodor et al. Zhurnal Obshchei Khimii, 1951 , vol. 21, p. 1897,1900; engl. Ausg. S. 2109, 2111 Show Details Takamizawa et al. Yakugaku Zasshi, 1958 , vol. 78, p. 637,642 Chemical and Pharmaceutical Bulletin, 1966 , vol. 14, p. 238 Chem.Abstr., 1958 , p. 18411

~%

73-66-5结构式

73-66-5

文献:Fodor et al. Zhurnal Obshchei Khimii, 1951 , vol. 21, p. 1897,1900; engl. Ausg. S. 2109, 2111 Show Details Takamizawa et al. Yakugaku Zasshi, 1958 , vol. 78, p. 637,642 Chemical and Pharmaceutical Bulletin, 1966 , vol. 14, p. 238 Chem.Abstr., 1958 , p. 18411

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73-66-5

详细
文献:Litvak, M. M. Pharmaceutical Chemistry Journal, 1989 , vol. 23, # 11 p. 935 - 938 Khimiko-Farmatsevticheskii Zhurnal, 1989 , vol. 23, # 11 p. 1374 - 1377

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详细
文献:Takamizawa; Maeda Yakugaku Zasshi, 1954 , vol. 74, p. 746 Chem.Abstr., 1955 , p. 11662 Show Details Takamizawa et al. Yakugaku Zasshi, 1958 , vol. 78, p. 637,642 Chemical and Pharmaceutical Bulletin, 1966 , vol. 14, p. 238 Chem.Abstr., 1958 , p. 18411 Show Details Takamizawa; Hirai Chemical and Pharmaceutical Bulletin, 1964 , vol. 12, p. 393,395
海关编码 2933599090
中文概述 2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素 品名, 成分含量, 用途, 乌洛托品请注明外观, 6-己内酰胺请注明外观, 签约日期
Summary 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%