68483-33-0

• 常用中文名：Apyramide
• 常用英文名：Apyramide
• CAS号：68483-33-0
• 分子式：C₂₇H₂₃ClN₂O₅
• 分子量：490.93500
• 相关类别： 研究领域 炎症/免疫
• 发布时间：2016-01-06 21:06:56
• 更新时间：2025-08-21 20:42:46
• Apyramide 是一种抗炎药物。

名称

• 中文名: Apyramide
• 英文名: (4-acetamidophenyl) 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetate
• 英文别名: Apyramide

物化性质

• 密度: 1.29g/cm3
• 沸点: 671.1ºC at 760 mmHg
• 分子式: C₂₇H₂₃ClN₂O₅
• 分子量: 490.93500
• 闪点: 359.6ºC
• 精确质量: 490.13000
• PSA: 90.12000
• LogP: 6.05620
• 折射率: 1.618
• 储存条件: 2-8℃

生物活性

• 描述: Apyramide 是一种抗炎药物。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 体内研究: 通过口服或ip途径,Apyramide在大鼠和小鼠中的毒性远低于吲哚美辛。它对角叉菜胶诱导的足爪水肿,棉球肉芽肿和佐剂性关节炎以及镇痛和解热活动具有抗炎活性[1]。
• 参考文献:

  [1]. Sauvaire D, et al. Pharmacological activity and toxicity of apyramide: comparison with non-steroidal anti-inflammatory agents. Drugs Exp Clin Res. 1987;13(5):247-52.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : NL3502000 CHEMICAL NAME : 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, 4-(acetylamino)phenyl ester CAS REGISTRY NUMBER : 68483-33-0 LAST UPDATED : 199612 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C27-H23-Cl-N2-O5 MOLECULAR WEIGHT : 490.97 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 887 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DECRDP Drugs under Experimental and Clinical Research. (Bioscience Ediprint, Blvd. James-Fazy 13, 1201 Geneva 1, Switzerland) V.1- 1977- Volume(issue)/page/year: 13,247,1987 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DECRDP Drugs under Experimental and Clinical Research. (Bioscience Ediprint, Blvd. James-Fazy 13, 1201 Geneva 1, Switzerland) V.1- 1977- Volume(issue)/page/year: 13,247,1987 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 380 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 12,203,1987 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 81600 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DECRDP Drugs under Experimental and Clinical Research. (Bioscience Ediprint, Blvd. James-Fazy 13, 1201 Geneva 1, Switzerland) V.1- 1977- Volume(issue)/page/year: 13,247,1987 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 4 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FRXXBL French Demande Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2358145