18717-72-1

• 常用中文名：NORCOCAINE
• 常用英文名：NORCOCAINE
• CAS号：18717-72-1
• 分子式：C₁₆H₁₉NO₄
• 分子量：289.32600
• 发布时间：2017-09-01 19:04:40
• 更新时间：2024-03-11 07:15:02

名称

• 英文名: Norcocaine Hydrochloride
• 英文别名: 4-O-methyl 3-O-phenyl 8-azabicyclo[3.2.1]octane-3,4-dicarboxylate

物化性质

• 密度: 1.24 g/cm3
• 沸点: 402.2ºC at 760 mmHg
• 熔点: 115ºC
• 分子式: C₁₆H₁₉NO₄
• 分子量: 289.32600
• 闪点: 197.1ºC
• 精确质量: 289.13100
• PSA: 64.63000
• LogP: 1.85430
• 外观性状: 白色结晶粉末
• 蒸汽压: 1.11E-06mmHg at 25°C

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : RD0400000 CHEMICAL NAME : 1-alpha-H,5-alpha-H-Nortropane-2-beta-carboxylic acid, 3-beta-hydroxy-, methyl ester, benzoate (ester) CAS REGISTRY NUMBER : 18717-72-1 LAST UPDATED : 198010 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C16-H19-N-O4 MOLECULAR WEIGHT : 289.36 WISWESSER LINE NOTATION : T56 A AMTJ FVO1 GOVR HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 40 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JATOD3 Journal of Analytical Toxicology. (Preston Pub. Inc., POB 48312, Niles, IL 60648) V.1- 1977- Volume(issue)/page/year: 4,19,1980

合成路线

50-36-2 ~90% 18717-72-1

文献：Georgetown University Patent: US6982271 B1, 2006 ; Location in patent: Page/Page column 21-22; Sheet 3 ; US 6982271 B1

67-56-1 ~% 18717-72-1

文献：Einhorn Chemische Berichte, 1888 , vol. 21, p. 3032,3441

53-21-4 ~% 18717-72-1

文献：Arinc, Emel; Bozcaarmutlu, Azra Journal of Biochemical and Molecular Toxicology, 2003 , vol. 17, # 3 p. 169 - 176