61034-15-9

• 常用中文名：CB-002
• 常用英文名：CB-002
• CAS号：61034-15-9
• 分子式：C₁₃H₁₃N₅O₂
• 分子量：271.27500
• 发布时间：2017-08-24 08:41:10
• 更新时间：2024-07-20 12:55:48
• CB-002 is a novel small molecule that restores p53 function in mutant p53-expressing colorectal cancer cells without toxicity to normal human fibroblasts; increases expression of endogenous p53 target genes NOXA, DR5, and p21 and cell death; decreases the stability of mutant p53 in RXF393 cancer cells and an exogenously expressed R175H p53 mutant in HCT116 p53-null cells.

名称

• 英文名: 8-anilino-1,3-dimethyl-7H-purine-2,6-dione
• 英文别名: 8-Anilino-1,3-dimethyl-3,7-dihydro-purin-2,6-dion; 8-Phenylaminotheophyllin; 8-anilino-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione; 8-Anilino-1,3-dimethyl-3,9-dihydro-1H-purine-2,6-dione; 8-phenylaminotheophylline; 8-anilino-1,3-dimethyl-3,7-dihydro-purine-2,6-dione; 1H-purine-2,6-dione,3,7-dihydro-1,3-dimethyl-8-(phenylamino); 8-anilino-1,3-dimethyl-3,7(9)-dihydro-purine-2,6-dione

物化性质

• 分子式: C₁₃H₁₃N₅O₂
• 分子量: 271.27500
• 精确质量: 271.10700
• PSA: 87.94000
• LogP: 0.12580