CB-002

• 常用名: CB-002
• 英文名: CB-002
• CAS号: 61034-15-9
• 分子量: 271.27500
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₃H₁₃N₅O₂
• 熔点: N/A
• 闪点: N/A

CB-002用途

CB-002 is a novel small molecule that restores p53 function in mutant p53-expressing colorectal cancer cells without toxicity to normal human fibroblasts; increases expression of endogenous p53 target genes NOXA, DR5, and p21 and cell death; decreases the stability of mutant p53 in RXF393 cancer cells and an exogenously expressed R175H p53 mutant in HCT116 p53-null cells.

CB-002名称

本表展示该化学物质的中文名称、英文系统名、各类中文与英文别名信息。

• 英文名: 8-anilino-1,3-dimethyl-7H-purine-2,6-dione

CB-002物理化学性质

本表包含该物质理化参数，如熔点、沸点、密度、溶解度、旋光性等理化指标，无数据项标记为N/A。

• 分子式: C₁₃H₁₃N₅O₂
• 分子量: 271.27500
• 精确质量: 271.10700
• PSA: 87.94000
• LogP: 0.12580
• InChIKey: RXCJTNUAETXUOY-UHFFFAOYSA-N
• SMILES: Cn1c(=O)c2[nH]c(Nc3ccccc3)nc2n(C)c1=O

CB-002靶点实验

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本表记录该化合物靶点、体外体内实验、生物测定实验相关实验数据。

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Counterscreen for inhibitors of the Steroid Receptor Coactivator 1 (SRC1; NCOA1): Lum... 来源：The Scripps Research Institute Molecular Screening Center 靶标：transactivating tegument protein VP16 [Human herpesvirus 1] External Id：VP16_INH_LUMI_1536_3X%INH CSRUN for SRC1

实验名称：Primary Screen Inhibitors of CD40 Signaling in BL2 Cells Measured in Cell-Based Syste... 来源：Broad Institute 靶标：N/A External Id：7124-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

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CB-002英文别名

本表罗列该化合物全部英文别名、系统命名、CAS别名等英文名称集合。

• 8-Anilino-1,3-dimethyl-3,7-dihydro-purin-2,6-dion
• 8-Phenylaminotheophyllin
• 8-anilino-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione
• 8-Anilino-1,3-dimethyl-3,9-dihydro-1H-purine-2,6-dione
• 8-phenylaminotheophylline
• 8-anilino-1,3-dimethyl-3,7-dihydro-purine-2,6-dione
• 1H-purine-2,6-dione,3,7-dihydro-1,3-dimethyl-8-(phenylamino)
• 8-anilino-1,3-dimethyl-3,7(9)-dihydro-purine-2,6-dione

CB-002常见问题

本部分为该化合物相关常见问答，包含基础参数、性状、储存条件等高频咨询问题与对应答案。

Q: 61034-15-9的英文名称是什么？

A: 61034-15-9英文名称为8-anilino-1,3-dimethyl-7H-purine-2,6-dione。

Q: 61034-15-9的分子量是多少？

A: 61034-15-9分子量为271.27500。

Q: 61034-15-9的极性表面积PSA是多少？

A: 61034-15-9极性表面积PSA为87.94000。

Q: 61034-15-9的CAS号是多少？

A: 61034-15-9CAS号为61034-15-9。

Q: 61034-15-9的InChIKey是什么？

A: 61034-15-9InChIKey为RXCJTNUAETXUOY-UHFFFAOYSA-N。

Q: 61034-15-9的SMILES表达式是什么？

A: 61034-15-9SMILES表达式为Cn1c(=O)c2[nH]c(Nc3ccccc3)nc2n(C)c1=O。

Q: 61034-15-9的分子式是什么？

A: 61034-15-9分子式为C13H13N5O2。

Q: 61034-15-9有哪些英文别名？

A: 61034-15-9英文别名有：8-Anilino-1,3-dimethyl-3,7-dihydro-purin-2,6-dion、 8-Phenylaminotheophyllin、 8-anilino-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione、 8-Anilino-1,3-dimethyl-3,9-dihydro-1H-purine-2,6-dione、 8-phenylaminotheophylline、 8-anilino-1,3-dimethyl-3,7-dihydro-purine-2,6-dione、 1H-purine-2,6-dione,3,7-dihydro-1,3-dimethyl-8-(phenylamino)、 8-anilino-1,3-dimethyl-3,7(9)-dihydro-purine-2,6-dione。

Q: 61034-15-9有什么用途？

A: 61034-15-9主要用途：CB-002 is a novel small molecule that restores p53 function in mutant p53-expressing colorectal cancer cells without toxicity to normal human fibroblasts; increases expression of endogenous p53 target genes NOXA, DR5, and p21 and cell death; decreases the stability of mutant p53 in RXF393 cancer cells and an exogenously expressed R175H p53 mutant in HCT116 p53-null cells.

Q: 61034-15-9的中文名称是什么？

A: 61034-15-9的中文名称为61034-15-9。