167263-11-8

• 常用中文名：4-苄基-1-(叔丁氧羰基)哌啶-4-羧酸
• 常用英文名：4-Benzyl-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid
• CAS号：167263-11-8
• 分子式：C₁₈H₂₅NO₄
• 分子量：319.395
• 发布时间：2018-12-13 21:32:21
• 更新时间：2024-01-24 07:03:31

名称

• 中文名: N-boc-4-苄基-4-哌啶羧酸
• 英文名: n-boc-4-benzyl-4-piperidinecarboxylic acid
• 英文别名: 4-Benzyl-piperidine; 4-benzylpiperazine; 4-benzylpyperidine; 4-benzylpiperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-methyl ester; 1-tert-butoxycarbonyl-4-phenylmethyl-piperidine-4-carboxylic acid; 4-benzylpiperidine-1,4-dicarboxylic acid mono-tert-butyl ester; 1,4-Piperidinedicarboxylic acid, 4-(phenylmethyl)-, 1-(1,1-dimethylethyl) ester; 4-benzylpiperidine-1,4-dicarboxylic acid tert-butyl ester; 4-Benzyl-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-4-piperidinecarboxylic acid; 1-tert-butyl 4-methyl 4-benzylpiperidine-1,4-dicarboxylate; Piperidine,4-benzyl; N-tert-butyloxycarbonyl-4-benzylpiperidine-4-carboxylic acid; 1-Boc-4-benzyl-4-piperidinecarboxylic acid; methyl 1-tert-butoxycarbonyl-4-phenylmethyl-piperidine-4-carboxylate; 4-benzyl-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 456.9±38.0 °C at 760 mmHg
• 分子式: C₁₈H₂₅NO₄
• 分子量: 319.395
• 闪点: 230.1±26.8 °C
• 精确质量: 319.178345
• PSA: 66.84000
• LogP: 3.23
• 蒸汽压: 0.0±1.2 mmHg at 25°C
• 折射率: 1.546
• 储存条件: 室温，密闭，干燥

安全

• 危害码 (欧洲): Xi

合成路线

741687-06-9 ~86% 167263-11-8

文献：ASTEX THERAPEUTICS LIMITED; THE INSTITUTE OF CANCER RESEARCH:ROYAL CANCER HOSPITAL; CANCER RESEARCH TECHNOLOGY LIMITED Patent: WO2007/125321 A2, 2007 ; Location in patent: Page/Page column 123 ; WO 2007/125321 A2

1126-09-6 24424-99-5 100-39-0 ~62% 167263-11-8

文献：D'Sidocky, Neil R.; Harris, Roy L.; Hegde, Sayee G.; Hilgraf, Robert; McCarrick, Margaret A.; McKie, Jeffrey A.; Mortensen, Deborah S.; Nadolny, Lisa; Perin-Ninkovic, Sophie M.; Sapienza, John J.; Wright, Jonathan L. Patent: US2008/242694 A1, 2008 ; Location in patent: Page/Page column 59 ; US 20080242694 A1

167263-10-7 ~% 167263-11-8

文献：Merck and Co., Inc. Patent: EP854870 B1, 2009 ; Location in patent: Page/Page column 27 ;

124443-68-1 ~% 167263-11-8

文献：Jiang, Xiao-Hua; Song, Yan-Li; Long, Ya-Qiu Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 14 p. 3675 - 3678

100-39-0 ~% 167263-11-8

文献：Jiang, Xiao-Hua; Song, Yan-Li; Long, Ya-Qiu Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 14 p. 3675 - 3678