62928-11-4

• 常用中文名：异丙铂
• 常用英文名：dichlorodihydroxybis(isopropylamine)platinum
• CAS号：62928-11-4
• 分子式：C₆H₂₀Cl₂N₂O₂Pt
• 分子量：418.21900
• 发布时间：2018-03-03 08:00:00
• 更新时间：2024-02-25 19:48:30

• 细胞抑制剂，和顺铂为同系物。有抗肿瘤作用。

名称

• 中文名: 异丙铂
• 英文名: dichlorodihydroxybis(isopropylamine)platinum
• 中文别名: 氯羟丙胺铂
• 英文别名: Ab-dichloro-ce-dihydroxy-df-bis(isopropylamine)platinum; PLATINUM,DICHLORODIHYDROXYBIS(2-PROPANAMINE); Iproplatin; [Pt(IV)Cl2(OH)2(NH2-i-Pr)2]; Platinum,dichlorodihydroxybis(2-propanamine)-,(oc-6-33); EINECS 263-762-5; cis,trans,cis-[Pt(isopropylamine)2(OH)2Cl2]; 2-Propanamine,platinum complex; cis-Dichloro-trans-dihydroxy-bis(isopropylamine)platinum; JM-9; cis-dichloro-trans dihydroxy-cis-bis(isopropylamine)platinum(IV); CHID

物化性质

• 沸点: 30.9ºC at 760 mmHg
• 分子式: C₆H₂₀Cl₂N₂O₂Pt
• 分子量: 418.21900
• 精确质量: 417.05500
• PSA: 92.50000
• LogP: 3.13050
• 更多:

  1.性状：结晶。

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TP2230500 CHEMICAL NAME : Platinum(IV), bis(isopropylammine)-cis-dichloro-trans-dihydroxy- CAS REGISTRY NUMBER : 62928-11-4 LAST UPDATED : 199803 DATA ITEMS CITED : 16 MOLECULAR FORMULA : C6-H20-Cl2-N2-O2-Pt MOLECULAR WEIGHT : 418.27 WISWESSER LINE NOTATION : ZY1&1 2 &Q-PT-QGG HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 60 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 92 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 30 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 60 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 45 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 18 mg/kg/9W-I TOXIC EFFECTS : Gastrointestinal - nausea or vomiting Blood - leukopenia Blood - thrombocytopenia TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 17500 ug/kg/5D-I TOXIC EFFECTS : Gastrointestinal - alteration in gastric secretion Gastrointestinal - other changes MUTATION DATA TYPE OF TEST : Mutation in mammalian somatic cells TEST SYSTEM : Rodent - hamster Lung DOSE/DURATION : 100 umol/L REFERENCE : EJCODS European Journal of Cancer and Clinical Oncology. (Pergamon Press, c/o Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591) V.17(7)- 25, 1981-89. For publisher information, see EJCAEL Volume(issue)/page/year: 25,27,1989

合成路线

97101-54-7 ~49% 62928-11-4

文献：Ermondi, Giuseppe; Caron, Giulia; Ravera, Mauro; Gabano, Elisabetta; Bianco, Sabrina; Platts, James A.; Osella, Domenico Dalton Transactions, 2013 , vol. 42, # 10 p. 3482 - 3489

82178-64-1 ~% 62928-11-4

文献：Journal of Chemical Research, Synopses, , p. 302 - 303

制备

二异丙胺二氯铂经双氧水氧化，引入二个羟基即得异丙铂。