62928-11-4

62928-11-4 structure
62928-11-4 structure
  • Name: dichlorodihydroxybis(isopropylamine)platinum
  • Chemical Name: dichlorodihydroxybis(isopropylamine)platinum
  • CAS Number: 62928-11-4
  • Molecular Formula: C6H20Cl2N2O2Pt
  • Molecular Weight: 418.21900
  • Create Date: 2018-03-03 08:00:00
  • Modify Date: 2024-02-25 19:48:30

Name dichlorodihydroxybis(isopropylamine)platinum
Synonyms Ab-dichloro-ce-dihydroxy-df-bis(isopropylamine)platinum
PLATINUM,DICHLORODIHYDROXYBIS(2-PROPANAMINE)
Iproplatin
[Pt(IV)Cl2(OH)2(NH2-i-Pr)2]
Platinum,dichlorodihydroxybis(2-propanamine)-,(oc-6-33)
EINECS 263-762-5
cis,trans,cis-[Pt(isopropylamine)2(OH)2Cl2]
2-Propanamine,platinum complex
cis-Dichloro-trans-dihydroxy-bis(isopropylamine)platinum
JM-9
cis-dichloro-trans dihydroxy-cis-bis(isopropylamine)platinum(IV)
CHID
Boiling Point 30.9ºC at 760 mmHg
Molecular Formula C6H20Cl2N2O2Pt
Molecular Weight 418.21900
Exact Mass 417.05500
PSA 92.50000
LogP 3.13050

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TP2230500
CHEMICAL NAME :
Platinum(IV), bis(isopropylammine)-cis-dichloro-trans-dihydroxy-
CAS REGISTRY NUMBER :
62928-11-4
LAST UPDATED :
199803
DATA ITEMS CITED :
16
MOLECULAR FORMULA :
C6-H20-Cl2-N2-O2-Pt
MOLECULAR WEIGHT :
418.27
WISWESSER LINE NOTATION :
ZY1&1 2 &Q-PT-QGG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
60 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
92 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
30 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
60 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
45 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
18 mg/kg/9W-I
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting Blood - leukopenia Blood - thrombocytopenia
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
17500 ug/kg/5D-I
TOXIC EFFECTS :
Gastrointestinal - alteration in gastric secretion Gastrointestinal - other changes

MUTATION DATA

TYPE OF TEST :
Mutation in mammalian somatic cells
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
100 umol/L
REFERENCE :
EJCODS European Journal of Cancer and Clinical Oncology. (Pergamon Press, c/o Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591) V.17(7)- 25, 1981-89. For publisher information, see EJCAEL Volume(issue)/page/year: 25,27,1989