1078-21-3

• 常用中文名：非尼布特
• 常用英文名：Phenibut
• CAS号：1078-21-3
• 分子式：C₁₀H₁₄ClNO₂
• 分子量：215.677
• 相关类别： 原料药 抑制剂
• 发布时间：2018-04-11 08:00:00
• 更新时间：2026-07-07 02:06:10
• 【用途一】
  用作抗抑郁药

名称

• 中文名: 4-氨基-3-苯基丁酸盐酸盐
• 英文名: 4-Amino-3-phenylbutyric acid hydrochloride
• 中文别名: 4-氨基-3-苯基-丁 酸; 菲尼布特; 菲尼布特(4-氨基-3苯基丁酸盐酸盐); 菲尼布特碱; 4-氨基-3-苯基丁酸; 4-氨基-3-苯基丁酸盐酸盐(菲尼布特); 4-氨基-3-苯基丁酸盐酸盐(非尼布特); 4-氨基苯丁酸盐酸盐; 3’-氯苯丙酮; 氯化(4-羟基-4-氧代-2-苯基-丁基)铵; 非尼布特(4-氨基-3-苯基丁酸盐酸盐); 巴氯芬杂质34(盐酸盐); 非尼布特,10 MM DMSO 溶液; 菲尼布特 PHENIBUT CAS, 4-氨基-3-苯基丁酸盐酸盐; 氯化(4-羟基-4-氧代-2-苯基丁基)铵
• 英文别名: 4-AMINO-3-PHENYLBUTYRIC ACID HCL; 3-PHENYL-4-AMINOBUTYRICACIDHCL; 4-amino-3-phenyl-butyricaci; 4-AMINO-3-PHENY-BUTYRICACIDHYDROCHLORIDE; Fenibut Phenibut; 4-amino-3-phenylbutanoicacid; 4-AMINO-3-PHENYL-BUTYRIC ACID; AMINOBUTYRIC ACID, beta-PHENYL-gaMMa-(P); fenigam; (4-hydroxy-4-oxo-2-phenyl-butyl)ammonium chloride; phenylgam; Phenibut 4-Amino-3-Phenylbutyric Acid; 4-azanyl-3-phenyl-butanoic acid; Phenibut HCl Powder; beta-phenyl-gamma-aminobutyrate; Phenibut Company Standds; fenigama; benzenepropanoic acid, β-(aminomethyl); UNII:625240H2LN; phenylgamma; 4-Amino-3-phenylbutanoic acid hydrochloride (1:1); Phenibut Powder; benzenepropanoic acid, .beta.-(aminomethyl); beta-phenyl-gamma-aminobutyricacid; Phenibut HCL; Amino-3-phenylbutyric acid hydrochloride; Phenybut; 4-AMINO-3-PHENYL BUTYRIC ACID HYDROCHLORIDE; EINECS 214-079-6; 4-Amino-3-pheny-butyric acid; (4-hydroxy-4-oxo-2-phenylbutyl)azanium chloride; phenigama; beta-(aminomethyl)-benzenepropanoicaci; 4-Amino-3-phenylbutanoic acid //BP; 4-Amino-3-phenylbutyric acid hydrchloride; β-Phenyl-γ-aminobutyric acid; Benzenepropanoic acid, β-(aminomethyl)-, hydrochloride (1:1); PHENYLBUT (4-AMINO-3-PHENYLBUTYRIC ACID HCL); beta-(aminomethyl)benzenepropanoicacid; PHENIBUTCAS NO.: 1-3 Phenibut CAS NO.1-3; Nootropics Powder Nutrition Supplement Phenibut for Fatigue Reduce; phenigam; TIMTEC-BB SBB001567; (4-hydroxy-4-keto-2-phenyl-butyl)ammonium chloride; pgaba; PHENIBUT; Phenibut (4-Amino-3-phenylbutyric acid HCl); Aminophenylbutyric acid; benzenepropanoic acid, b-(aMinoMethyl); (4-hydroxy-4-oxo-2-phenyl-butyl)azanium chloride; MFCD00456233; beta-(aminomethyl)hydrocinnamicacid; HYDROCINNAMIC ACID, beta-(AMINOMETHYL)-, HYDROCHLORIDE; 4-Amino-3-phenylbutyric acid Hcl; (4-hydroxy-4-oxo-2-phenylbutyl)ammonium chloride; PhGABA; butyric Acid HydrochL; B-(Aminomethyl)-benzenropionic acid hydrochloride; 4-Amino-3-phenylbutanoic acid Hydrochloride, Phenibut; Phenibut, 4-Amino-3-phenylbutanoic acid; FENIBUT; 4-Amino-3-phenyl; Phenygam; 4-AMINO-3-PHENYLBUTIRIC ACID; NA###4-Amino-3-phenylbutyric acid hydrochloride

物化性质

• 熔点: 194.0-202.0°C
• 分子式: C₁₀H₁₄ClNO₂
• 分子量: 215.677
• 精确质量: 215.071304
• PSA: 63.32000
• LogP: 2.70590
• 外观性状: 粉末
• 储存条件: -20℃
• 分子结构:

  1、 摩尔折射率：50.17

  2、 摩尔体积（cm³/mol）：154.3

  3、 等张比容（90.2K）：412.9

  4、 表面张力（dyne/cm）：51.2

  5、 极化率（10-24cm3）：19.88

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : ES7175000 CHEMICAL NAME : Butyric acid, 4-amino-3-phenyl- CAS REGISTRY NUMBER : 1078-21-3 BEILSTEIN REFERENCE NO. : 2804903 LAST UPDATED : 199701 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C10-H13-N-O2 MOLECULAR WEIGHT : 179.24 WISWESSER LINE NOTATION : Z1YR&1VQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human DOSE/DURATION : 5 mg/kg TOXIC EFFECTS : Behavioral - sleep Behavioral - somnolence (general depressed activity) Behavioral - hallucinations, distorted perceptions REFERENCE : BEXBAN Bulletin of Experimental Biology and Medicine (English Translation). Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.41- 1956- Volume(issue)/page/year: 57,52,1964 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 700 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BEXBAN Bulletin of Experimental Biology and Medicine (English Translation). Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.41- 1956- Volume(issue)/page/year: 57,52,1964 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 900 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BEXBAN Bulletin of Experimental Biology and Medicine (English Translation). Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.41- 1956- Volume(issue)/page/year: 57,52,1964

安全

• 危害码 (欧洲): Xi
• 海关编码: 2922499990

制备

【方法一】
将a-甲酯基-β-苯基-г-四氢吡咯烷酮加入盐酸进行水解，干燥后即得1078-21-3（4-氨基-3-苯基丁酸盐酸盐）

海关

海关编码	2922499990
中文概述	2922499990 其他氨基酸及其酯及它们的盐（含有一种以上含氧基的除外）. 增值税率:17.0% 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 最惠国关税:6.5% 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
监管条件	A.入境货物通关单 B.出境货物通关单
检验检疫	P.进境动植物、动植物产品检疫 Q.出境动植物、动植物产品检疫 R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验
Summary	HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%