101903-30-4

101903-30-4结构式

常用中文名：稻瘟酯
常用英文名：pefurazoate
CAS号：101903-30-4
分子式：C₁₈H₂₃N₃O₄
分子量：345.39300
相关类别：化学农药原药杀菌剂其他杀菌剂
发布时间：2018-03-23 08:00:00
更新时间：2024-01-04 06:36:40
咪唑类杀菌剂。用于水稻种子处理，对防治种子传播的病原真菌，特别是水稻作物中由串珠镰孢引起的水稻恶苗病、由稻梨孢引起的稻瘟病和宫部旋孢腔菌引起的水稻胡麻叶斑病卓有成效。低浓度施用时，通过阻断麦角甾醇的生物合成，抑制萌发管和菌系的生长，来阻止种传病原真菌的生长发育。对苯并咪唑类杀菌剂具有抗性的串珠镰孢有效。

中文名	稻瘟酯
英文名	pefurazoate
中文别名	N-糠基-N-咪唑-1-基羧基-DL-高丙氨酸戊-4-烯酯净种灵戊-4-烯基-N-糠基-N-咪唑-1-基羰基-DL-高丙氨酸酯拌种唑
英文别名	Butanoic acid,2-((2-furanylmethyl)(1H-imidazol-1-ylcarbonyl)amino)-,4-pentenyl ester pent-4-enyl (2RS)-2-[furfuryl(imidazol-1-ylcarbonyl)amino]butyrate 4-Pentenyl 2-((2-furanylmethyl)(1H-imidazol-1-ylcarbonyl)amino)butanoate Pefurazoate Pent-4-enyl N-furfuryl-N-imidazol-1-ylcarbonyl-DL-homoalaninate (IUPAC) UR 003 pent-4-enyl N-furfuryl-N-imidazol-1-ylcarbonyl-DL-homoalaninate UHF-8615 Healthied Pefurazoate [ISO:BSI] pent-4-enyl 2-[furan-2-ylmethyl(imidazole-1-carbonyl)amino]butanoate 4-pentenyl 2-[(2-furanylmethyl)(1H-imidazol-1-ylcarbonyl)amino]butanoate

密度	1.16g/cm3
沸点	455ºC at 760mmHg
熔点	25°C
分子式	C₁₈H₂₃N₃O₄
分子量	345.39300
闪点	229ºC
精确质量	345.16900
PSA	77.57000
LogP	3.23440
蒸汽压	1.82E-08mmHg at 25°C
折射率	1.555
稳定性	在酸性情况下稳定，碱性情况下稍不稳定
分子结构	1、摩尔折射率：95.48 2、摩尔体积（cm³/mol）：297.4 3、等张比容（90.2K）：762.3 4、表面张力（dyne/cm）：43.1 5、极化率（10-24cm3）：37.85
计算化学	1.疏水参数计算参考值（XlogP）:2.8 2.氢键供体数量:0 3.氢键受体数量:5 4.可旋转化学键数量:10 5.互变异构体数量:无 6.拓扑分子极性表面积77.6 7.重原子数量:25 8.表面电荷:0 9.复杂度:458 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:1 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:1
更多	1.性状：外观带淡棕色液体。 2.相对密度：1.152(20℃) 3.沸点（ºC,常压）：235℃(分解) 4.蒸气压（kPa,25ºC）：6.48×10-4Pa(23℃) 5.溶解性：25℃时溶解度：二甲基亚砜、乙醇、丙酮、乙腈、氯仿、乙酸乙酯、甲苯均>1000 g/L，环己烷36.9g/L，正己烷12.0g/L，水0.443g/L。

毒理学数据:

大鼠急性经口LD₅₀981mg/kg(雄)、1051 mg/kg(雌)，小鼠急性经口LD₅₀1299mg/kg(雄)、946mg/kg(雌)；雌、雄大鼠急性经皮LD₅₀＞2000mg/kg；雌、雄大鼠急性吸入LC₅₀＞3450mg/m³。对兔眼睛有轻微刺激，对兔皮肤无刺激作用。豚鼠皮肤无致敏性。大量短期和长期毒性试验表明，该化合物对细菌无诱变作用，对大鼠和兔不会致畸，对大鼠、小鼠、兔、豚鼠的药理学研究未见有害影响。鲤鱼LC₅₀16.9mg/L(48h)，鲫鱼LC₅₀20.0 mg/L(48h)，硬头鳟LC₅₀4.0 mg/L (48h)，剑蚤LC₅₀＞100mg/L (6h)。蜜蜂接触

LD₅₀100μg／只。鹌鹑急性经口LD₅₀2380 mg/kg，鸡急性经口LD₅₀4228mg/kg。

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EK7870000

CHEMICAL NAME :: Butanoic acid, 2-((2-furanylmethyl)(1H-imidazol-1-ylcarbonyl)amino)- , 4-pentenyl ester

CAS REGISTRY NUMBER :: 101903-30-4

LAST UPDATED :: 199512

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C18-H23-N3-O4

MOLECULAR WEIGHT :: 345.44

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 981 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (57),33,1990

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >3450 mg/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (57),33,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (57),33,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 946 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (57),33,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 4220 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (57),33,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: 2380 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (57),33,1990 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1847 mg/kg/13W-C

TOXIC EFFECTS :: Liver - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases

REFERENCE :: NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 16,703,1991

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 13104 mg/kg/52W-C

TOXIC EFFECTS :: Behavioral - food intake (animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 16,563,1991 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 4550 mg/kg

SEX/DURATION :: female 6-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 16,703,1991

101903-30-4	13286-32-3
50512-35-1	115852-48-7
26087-47-8	17109-49-8
21722-85-0	115-31-1
27355-22-2	2079-00-7
1158522-08-7	1207027-20-0
878066-33-2	940364-43-2
134104-43-1	131615-57-1
6906-52-1	930439-75-1
1018584-77-4	1375289-11-4