34540-22-2

• 常用中文名：羟基积雪草苷
• 常用英文名：Madecassoside
• CAS号：34540-22-2
• 分子式：C₄₈H₇₈O₂₀
• 分子量：975.121
• 相关类别： 生物化工 植物提取物
• 发布时间：2018-04-22 08:00:00
• 更新时间：2026-07-04 14:33:01
• Madecassoside是一个从崩大碗中分离出来的五环三萜,有抗炎症。抗氧化和抗衰老的作用。

名称

• 中文名: 羟基积雪草苷
• 英文名: madecassoside
• 中文别名: 羟基积雪草苷/HPLC; 积雪草苷A; 羟基积雪草苷(白色); 羟基积雪草苷(标准品); (1S,2R,4aS,6aS,6bR,8R,8,9R,10R,11R,12,12bR,14bS)-(2S,3R,4S,5S,6R)-6-((((2R,3R,4R,5S,6R)-3,4-二羟基-6-(羟甲基)-5-(((2S,3R,4R,5R,6S)-3,4,5-三羟基-6-甲基四氢-2H-吡喃-2-基)氧基)四氢-2H-吡喃-2-基)氧基)甲基)-3,4,5-三羟基四氢-2H-吡喃-2-基 8,10,11-三羟基-9-(羟甲基)-1,2,6a,6b,9,12a-六甲基-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-二十氢苉-4a-羧酸酯; 羟基积雪草苷, 来源于积雪草; (1S,2R,4AS,6AS,6BR,8R,8,9R,10R,11R,12,12BR,14BS)-(2S,3R,4S,5S,6R)-6-((((2R,3R,4R,5S,6R)-3,4-二羟基-6-(羟甲基)-5-(((2S,3R,4R,5R,6S)-3,4,5-三羟基-6-甲基四氢-2H-吡喃-2-基)氧基)四氢-2H-吡喃-2-基)氧基)甲基)-3,4,5-三羟基四氢-2H-吡喃-2-基 8,10,11-三羟基-9-(羟甲基)-1,2,6A,6B,9,12A-六甲基-1,2,3,4,4A,5,6,6A,6B,7,8,8A,9,10,11,12,12A,12B,13,14B-二十氢苉; (1S,2R,4AS,6AS,6BR,8R,8,9R,10R,11R,12,12BR,14BS)-(2S,3R,4S,5S,6R)-6-((((2R,3R,4R,5S,6R)-3,4-二羟基-6-(羟甲基)-5-(((2S,3R,4R,5R,6S)-3,4,5-三羟基-6-甲基四氢-2H-吡喃-2-基)氧基)四氢-2H-吡喃-2-基)氧基)甲基)-3,4,5-三羟基四氢-2H-吡喃-2-基 8,10,11-三羟基-9-(羟甲基)-1,2,6A,6B,9,12A-六甲基-1,2,3,4,4; 羟基积雪草苷 34-2; 羟基积雪草苷(对照品); 羟基积雪草苷(积雪草苷A); 羟基积雪草; 羟基积雪草苷Madecassoside; 羟基积雪草苷 from Centella asiatica34-2; 羟基积雪草甘; 羟基积雪草甙; MADECASSOSIDE 羟基积雪草苷; MADECASSOSIDE 羟基积雪草苷 标准品
• 英文别名: Madecassoside (8CI); (1S,2R,4aS,6aS,6bR,8R,8,9R,10R,11R,12,12bR,14bS)-(2S,3R,4S,5S,6R)-6-((((2R,3R,4R,5S,6R)-3,4-Dihydroxy-6-(hydroxymethyl)-5-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)methyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl 8,10,11-trihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-cboxylate; Madecassoside (Asiaticoside A); Madecassoside from Centella asiatica; Asiaticoside A; MADESOIDE; O-6-Deoxy-alpha-L-mannopyranosyl-(1.4)-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl (2alpha,3beta,4alpha,6beta)-2,3,6,23-tetrahydroxyurs-12-en-28-oate; 6-Deoxy-α-L-mannopyranosyl-(1->4)-β-D-glucopyranosyl-(1->6)-1-O-[(2α,3β,6β,14β)-2,3,6,23-tetrahydroxy-28-oxours-12-en-28-yl]-β-D-glucopyranose; Madecassoside-RM; O-6-deoxy-alpha-L-mannopyranosyl-(1-)-O-beta-D-glucopyranosyl-(1-)-beta-D-glucopyranosyl (2alpha,3beta,4alpha,6beta)-2,3,6,23-tetrahydroxyurs-12-en-28-oate; MADECASSOSIDE hplc; Madecassoside, froM Centella asiatica; Centella Asiatica Extract Madecassoside; glucopyranosyl-(1→6)-β-D-glucopyranosyl ester, (2α,3β,4α,6β); 2α,3β,6β,23-Tetrahydroxyurs-12-en-28-oic acid 6-O-[4-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]-β-D-glucopyranosyl ester; RederMic; MADECASSOSIDE; Madecassoside from Centella asiatica (L.) Urb; Urs-12-en-28-oicacid, 2,3,6,23-tetrahydroxy-, O-6-deoxy-α-L-mannopyranosyl-(1→4)-O-β-D; Urs-12-en-28-oic acid, 2,3,6,23-tetrahydroxy-, O-6-deoxy-α-L-mannopyranosyl-(1→4)-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl ester, (2α,3β,4α,6β); MADECASSOIDE; MADECASSOSIDE(P); MADESOSIDE

物化性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 1043.6±65.0 °C at 760 mmHg
• 分子式: C₄₈H₇₈O₂₀
• 分子量: 975.121
• 闪点: 295.8±27.8 °C
• 精确质量: 974.508667
• PSA: 335.44000
• LogP: 1.88
• 外观性状: 白色粉末
• 蒸汽压: 0.0±0.6 mmHg at 25°C
• 折射率: 1.637
• 储存条件: 2-8°C
• 水溶解性: H2O: soluble1mg/mL, clear, colorless

生物活性

• 描述: Madecassoside是一个从崩大碗中分离出来的五环三萜,有抗炎症。抗氧化和抗衰老的作用。
• 相关类别:
  信号通路 >> 其他 >> 其他
  天然产物 >> 萜类化合物和糖苷
  研究领域 >> 其他
• 参考文献:

  [1]. Zexin Li et al. Madecassoside suppresses proliferation and invasiveness of HGF-induced human hepatocellular carcinoma cells via PKC-cMET-ERK1/2-COX-2-PGE2 pathway. Int Immunopharmacol. 2016 Apr;33:24-32.

  [2]. Xia Y et al. Madecassoside ameliorates bleomycin-induced pulmonary fibrosis in mice through promoting the generation of hepatocyte growth factor via PPAR-γ in colon. Br J Pharmacol. 2016 Apr;173(7):1219-35

  [3]. Su Z et al. Protective effects of madecassoside against Doxorubicin induced nephrotoxicity in vivo and in vitro. Sci Rep. 2015 Dec 14

安全

• 危害码 (欧洲): Xn
• 安全声明 (欧洲): 24/25
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 3
• RTECS号: YU9625000