54739-18-3

• 常用中文名：氟伏沙明
• 常用英文名：Fluvoxamine
• CAS号：54739-18-3
• 分子式：C₁₅H₂₁F₃N₂O₂
• 分子量：318.335
• 相关类别： 原料药 神经系统用药 抗抑郁、躁狂药
• 发布时间：2018-02-14 08:00:00
• 更新时间：2026-07-01 07:04:36
• Fluvoxamine是5-羟色胺再吸收抑制剂,有抗抑郁活性。

名称

• 中文名: 氟提肟氨
• 英文名: fluvoxamine
• 中文别名: 甲醇中氟伏沙明; 氟伏沙明Fluvoxamine; 氟伏沙明检测标准品; (E)-5-甲氧基-4-三氟甲基苯戊酮氧-2-氨乙酰基肟; 氟伏沙明(反式); 氟伏沙明杂质7; 氟伏沙明F603500; 氟伏沙明 54-3; 马来酸氟伏沙明杂质D3; (E)-5-甲氧基-1-(4-(三氟甲基)苯基)戊-1-酮 O-(2-氨基乙基)肟; 氟伏沙明系列杂质标准品、对照品; 氟伏沙明-D3; 甲醇中氟伏沙明标准溶液
• 英文别名: Fluvoxamine Impurity 7; Fluvoxamine in Methanol; Fluvoxamine Also See: F603500; 5-methoxy-1-[4-(trifluoromethyl)-phenyl]-1-pentanone O-(2-aminoethyl)oxime; (1E)-5-Methoxy-1-[4-(trifluoromethyl)phenyl]pentanal O-(2-aminoethyl)oxime; δ-Methoxy-4'-(trifluoromethyl)valerophenone (E)-O-(2-aminoethyl)oxime; (E)-5-methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanoneo-(2-aminoethyl)oxime; 1-Pentanone, 5-Methoxy-1-[4-(trifluoroMethyl)phenyl]-, O-(2-aMinoethyl)oxiMe, (1E); 2-{[(E)-{5-Methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene}amino]oxy}ethanamine; 5-Methoxy-4’-(triflluoromethyl)valerophenone(E)-O-(2-aminoethyl) oxime; (E)-5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone O-(2-Aminoethyl)oxime; (E)-ω-Methoxy-4'-(trifluoromethyl)valerophenone O-(2-aminoethyl)oxime; Faverin; Fluvoxamine See: F603500; Floxyfral; FLUVOXAMINE; Fluvoxamine //BP; Dumirox; Maveral; 5-methoxy-1-[4-(trifluoromethyl)-phenyl]-1-pentanone-0-(2-aminoethyl)oxime; 2-[({(1E)-5-Methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene}amino)oxy]ethanamine; Luvox; MFCD00865345; 2-[[5-methoxy-1-[4-(trifluoromethyl)phenyl]-pentylidene]amino]oxyethanamine; Fevarin; 2-[(E)-[5-methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene]amino]oxyethanamine; 5-Methoxy-4'-(trifluoromethyl)valerophenone (E)-O-(2-aminoethyl)oxime

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 370.6±52.0 °C at 760 mmHg
• 熔点: 120-122.5ºC
• 分子式: C₁₅H₂₁F₃N₂O₂
• 分子量: 318.335
• 闪点: 177.9±30.7 °C
• 精确质量: 318.155518
• PSA: 56.84000
• LogP: 3.11
• 外观性状: 透明无色油状
• 蒸汽压: 0.0±0.8 mmHg at 25°C
• 折射率: 1.474
• 储存条件: -20°C Freezer, Under Inert Atmosphere

生物活性

• 描述: Fluvoxamine是5-羟色胺再吸收抑制剂,有抗抑郁活性。
• 相关类别:
  信号通路 >> 神经信号通路 >> 5-羟色胺转运蛋白
  研究领域 >> 神经疾病
  天然产物 >> 生物碱
• 参考文献:

  [1]. Escalona, R., et al., Fluvoxamine treatment in veterans with combat-related post-traumatic stress disorder. Depress Anxiety, 2002. 15(1): p. 29-33.

  [2]. Ginsburg, B.C., J.W. Pinkston, and R.J. Lamb, The potency of fluvoxamine to reduce ethanol self-administration decreases with concurrent availability of food. Behav Pharmacol, 2012. 23(2): p. 134-42.

  [3]. Claassen, V., et al., Fluvoxamine, a specific 5-hydroxytryptamine uptake inhibitor. Br J Pharmacol, 1977. 60(4): p. 505-16.

安全

• 海关编码: 2928000090

海关

海关编码	2928000090
中文概述	2928000090 其他肼（联氨）及胲（羟胺）的有机衍生物。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%