134790-39-9

• 常用中文名：2'-脱氧-3',5'-二-O-苯甲酰基-2',2'-二氟胞苷
• 常用英文名：2',2'-Difluoro-2'-deoxycytidine-3',5'-dibenzoate
• CAS号：134790-39-9
• 分子式：C₂₃H₁₉F₂N₃O₆
• 分子量：471.410
• 相关类别： 生物化工 核苷类药物 脱氧核苷酸及其类似物
• 发布时间：2018-12-04 11:56:05
• 更新时间：2026-07-01 18:52:59

名称

• 中文名: 2’,2’-二氟-2’-脱氧胞嘧啶核苷-3’,5’-二苯甲酸酯
• 英文名: 2',2'-Difluoro-2'-deoxycytidine-3',5'-dibenzoate
• 中文别名: 2',2'-二氟-3',5'-二苯甲酰基-2'-脱氧胞苷; 2-脱氧-2,2-二氟-3,5-二苯甲酰基胞苷; 2',2'-二氟-2'-脱氧胞嘧啶核苷-3',5'-二苯甲酸酯(T9); 吉西他滨中间体T9; (2R,3R,5R)-5-(4-氨基-2-氧代嘧啶-1(2H)-基)-2-((苄氧基)甲基)-4,4-二氟四氢呋喃-3-基苯甲酸酯; 2',2'-二氟-2'-脫氧胞嘧啶核苷-3',5'-二苯甲酸酯; 吉西他滨杂质6 BETA胞苷; 氢溴酸加兰他敏杂质9; 2,2-二氟-3,5-二苯甲酸酯-2-脱氧胞嘧啶核苷; 2',2'-二氟-2'-脱氧胞嘧啶核苷-3',5'-二苯甲酸酯; 3',5'-二-O-苯甲酰基-2'-脱氧-2',2'-二氟胞苷(中间体/医药中间...); 盐酸吉西他滨T8; (2R,3R,5R)-5-(4-氨基-2-氧代嘧啶-1(2H)-基)-2-((苯甲酰氧基)甲基)-4,4-二氟四氢呋喃-3-基苯甲酸酯; 2',2'-二氟-2'-脱氧胞嘧啶核苷-3',5'-二苯甲酸酯(吉西他滨T9); 吉西他滨中间体5 2-脱氧-2,2-二氟-3,5-二苯甲酰基胞苷; 2'-脱氧- 3',5'-二- O-苯甲酰-2',2' -二氟胞啶; 2'-脱氧-3' ,5'-二-O-苯甲酰基-2' ,2'-二氟胞苷; BETA胞苷; 2-脱氧-2,2-二氟-D-呋喃核糖-胞苷-3,5-二苯甲酸酯-1-甲基磺酸酯(T8); 吉西他滨中间体3; Β-2'-脱氧-2', 2'-二氟胞苷-3',5'-二苯甲酸酯; 二苯甲酰吉西他滨; 2',2'-DIFLUORO-2'-DEOXYCYTIDINE-3',5'-DIBENZOATE2',2'-二氟-2'-脱氧胞嘧啶核苷-3',5'-二苯甲酸酯; 加兰他敏杂质9; 吉西他滨T9; 中间体:2',2'-二氟-2'-脱氧胞嘧啶核苷-3',5'-二苯甲酸酯; 2',2'-二氟-3',5'-二苯甲酰-2'-脱氧胞苷; 2',2'-二氟-3',5'-二苯甲酸酯-2'-脱氧胞嘧啶核苷; 3',5'-二-O-苯甲酰基-2'-脱氧-2',2'-二氟胞苷; 2',2'-二氟-3',5'-二苯甲酸酯-2'-脱氧胞嘧啶核苷/T9
• 英文别名: T9, 2',2'-Difluoro-2'-deoxycytidine-3',5'-dibenzoate; 2'-Deoxy-2',2'-difluro-3'5'-bis-O-benzoylcytidine; 2'-Deoxy-2',2'-difluorocytidine-3',5'-dibenzoate, 1-(3,5-Bis-O-benzoyl-2-deoxy-2,2-difluoro-beta-D-ribofuranosyl)cytosine; 2',2'-difluoro-2'-deoxycytidine-3',5'-dibenzoate; Gemcitabine T9 Intermediate; 2-DEOXY-2,2-DIFLUORO-35-BIS-O-BENZOYLEYTIDINE MONOHYDROCHLORIDE; 3',5'-Di-O-benzoyl-2'-deoxy-2',2'-difluorocytidine; (2R,3R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3-(benzoyloxy)-4,4-difluorooxolan-2-yl]methyl benzoate; Cytidine, 2'-deoxy-2',2'-difluoro-, 3',5'-dibenzoate (9CI); 3',5'-Bis-O-benzoyl-2'-deoxy-2',2'-difluorocytidine; (2R,3R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4,4-difluorotetrahydrofuran-3-yl benzoate; (2R,3R,5R)-5-(4-amino-2-oxopyriMidin-1(2H)-yl)-2-(benzoyloxyMethyl)-4,4-difluorotetrahydrofuran-3-yl benzoate; 2-[[5-(4-amino-2-oxo-1-pyrimidinyl)-3-(2-cboxylatophenyl)-4,4-difluoro-3-hydroxy-2-oxolanyl]-hydroxymethyl]benzoate; 2',2'-Difluoro-2'-deoxycyodine-3',5'–dibenzoate ( or its salt) 2'-deoxy-2',2'-difluoro-3',5'-di-O-benzoates-cytidine (or its salt); 2’-Deoxy-2’,2’-difluoro-3’,5’-bis-O-benzoylcytidine; Cytidine, 2'-deoxy-2',2'-difluoro-, 3',5'-dibenzoate; GeMcitabine InterMediate 9; TB-T9; 2'-Deoxy-3',5'-di-O-benzoyl-2',2'-difluorocytidine, >=; [(2R,3S,5R)-5-(4-amino-2-oxo-1,2-dihydropyriMidin-1-yl)-3-(benzoyloxy)-4,4-difluorooxolan-2-yl]Methyl benzoate; Difluoro-2'; 2'-deoxy-2,2'-difluoro-3,5-dibenzyl-cytidine; 2',2'-Difluoro-2'-deoxycytidine-3',5'-dibenzoate (Gemcitabine impurity); 3',5'-Di-O-benzoyl-2',2'-difluoro-2'-deoxy cytidine; 2',2'-Difluoro-2'-deoxycytidine-3',5'-dibenzoate (T9); T9 of Gemcitabine; Gemcitabine alpha-Anomer; Chloropurine riboside; 2’,2’-Difluoro-2’-deoxycyodine-3’,5’-dibenzoate; 2',2'- difluoro -2'- deoxycytosine nucleoside -3',5'- dibenzoate; 2′-Deoxy-3′,5′-di-O-benzoyl-2′,2′-difluorocytidine; 2,2-DIFLOURO-2-DEOXYCYTIDINE-3,5-DIBENZOATE; 2',2'-Difluoro-2'-deoxycytidine-3',5'-dibenzoate //BP; (2R,3R,5R)-5-(4-amino-2-oxopyrimidin; Gemcitabine impurity 4/2',2'-Difluoro-2'-deoxycytidine-3',5'-dibenzoate; dibenzoate; deoxycytidine-3'; 2’-Deoxy-3’,5’-di-O-benzoyl-2’,2’-difluorocytidine; 3',5'-Di-O-benzoyl-gemcitabine - Bio-X

物化性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 608.4±65.0 °C at 760 mmHg
• 熔点: 229-232°C
• 分子式: C₂₃H₁₉F₂N₃O₆
• 分子量: 471.410
• 闪点: 321.7±34.3 °C
• 精确质量: 471.124207
• PSA: 122.74000
• LogP: 4.56
• 外观性状: 黄褐色固体
• 蒸汽压: 0.0±1.7 mmHg at 25°C
• 折射率: 1.625
• 储存条件: Refrigerator

安全

• 海关编码: 2934999090

合成路线

1173824-58-2 ~% 134790-39-9

文献：Synthesis, , # 6 p. 565 - 570

122111-01-7 ~% 134790-39-9

文献：Synthesis, , # 6 p. 565 - 570

134877-42-2 18037-10-0 ~% 134790-40-2 134790-39-9

文献：Synthesis, , # 6 p. 565 - 570

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1173824-58-2 122111-01-7 134877-42-2 18037-10-0
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海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%