4803-74-1

• 常用中文名：5,6-二甲氧基-2-(4-吡啶基)亚甲基-1-茚酮
• 常用英文名：5,6-Dimethoxy-2-(pyridine-4-yl)methylene-indan-1-one
• CAS号：4803-74-1
• 分子式：C₁₇H₁₅NO₃
• 分子量：281.306
• 相关类别： 医药中间体 杂环化合物 吡啶类化合物 吡啶衍生物
• 发布时间：2018-12-18 14:24:44
• 更新时间：2026-07-03 17:32:31

名称

• 中文名: 5,6-二甲氧基-2-(4-吡啶基)亚甲基-1-茚酮
• 英文名: 5,6-Dimethoxy-2-(pyridine-4-yl)methylene-indan-1-one
• 中文别名: 盐酸多奈哌齐DE2 :( 5,6-二甲氧基-2-(4-吡啶基)亚甲基-1-茚酮); 茚酮M1; 吡啶茚满酮; 5,6-二甲氧基-2-(4-吡啶基)亚甲基-1-茚酮(多奈哌齐杂质); 2-[(4-吡啶基)亚甲基]-5,6-二甲氧基-1-茚酮; 5,6-二甲氧基-2-(4-吡啶基亚甲基; 多奈哌齐杂质N; (Z)-5,6- 二甲氧基 -2-(4- 吡啶亚甲基 )-2,3- 二氢茚酮; 称 5,6-二甲氧基-2-(4-吡啶基)亚甲基-1-茚酮; 多奈哌齐杂质；5,6-二甲氧基-2-(4-吡啶基)亚甲基-1-茚酮; 多奈哌齐杂质48; 多奈派齐中间体; 多奈派齐中间体,5,6-二甲氧基-2-(4-吡啶基亚甲基)-1-茚酮; 多奈哌齐杂质23; 多奈哌齐杂质33; 5,6-二甲氧基-2-(4-吡啶基亚甲基)-1-茚满酮(多奈哌齐的杂质)
• 英文别名: 5,6-Dimethoxy-2-[(4-pyridyl)methylene]indan-1-one; 5,6-Dimethoxy-2(pyridine-4-yl-methelene-indane-1-one; (2Z)-5,6-Dimethoxy-2-(4-pyridinylmethylene)-1-indanone; (E)-5,6-Dimethoxy-2-pyridin-4-ylmethylene-indan-1-one; 5,6-Dimethoxy-2-(pyridin-4-ylmethylene)-2,3-dihydro-1H-inden-1-one; 4-[(5,6-Dimethoxy-1-Indanone) -2-Methyl] Pyridine; Donepezil Impurity 23; 1-Indanone,5,6-dimethoxy-2-(4-pyridylmethylene)- (7CI,8CI); 5,6-dimethoxyl-2-(piperidin-4-y)methylene-indan-1-one; Donezil Pyridine Dehydro Impurity; 5,6-Dimethoxy-2-(pyridine-4-yl)methylene-indan-1-one 2,3-Dihydro-5,6-dimethoxy-2-(4-pyridinylmethylene)-1H-inden-1-one; Donezil Impurity D; 5,6-DIMETHOXY-2-(4-PYRIDYLMETHYLENE)-1-INDANONE; Donezil Impurity 23; Letimovir intermediate; 5,6-DiMethoxy-2-(pyridin-4-ylMethylene)-2,3-dihydro-1H-inden-1-one; 5,6-Dimethoxy-2-(pyridin-4-ylmethylene)-2,3-dihydro-1H-inden-1-one (Donezil Impurity); 5,6-Dimethoxy-2-(4-pyridylmethylene)-1-indanone (Donezil Impurity); 5,6-DIMETHOXY-2-(PYRIDINE-4-YL)METHYLENE-INDAN-1-ONE; (E)-5,6-dimethoxy-2-(pyridin-4-ylmethylene)-2,3-dihydro-1H-inden-1-one; (E)-2,3-dihydro-5,6-dimethoxy-2-((pyridin-4-yl)methylene)inden-1-one; 1H-Inden-1-one,2,3-dihydro-5,6-diMethoxy-2-(4-pyridinylMethylene); Donezil Impurity 48; (2E)-5,6-dimethoxy-2-(pyridin-4-ylmethylidene)-3H-inden-1-one; 5,6-Dimethoxy-2-[(4-pyridyl)methyle; 5,6-Dimethoxy-2-(4-pyridylmethylene)-1-indanone (Donepezil Impurity); MFCD08458868; Donezil pyridine dehydro Imp; 5, 6-dimethoxy-2 -(4-pyridyl) methylene-1-indone; 5,6-dimethoxy-2-(pyridin-4-ylmethylene)-2,3-dihydroinden-1-one; 5,6-Dimethoxy-2-(pyridine-4-yl)methylene-indan-1-one ISO 9001：2015 REACH; Donrzil Pyridine Dehydro Imp; 5,6-Dimethoxy-2- (4-pyridyl) methyl-1-indenone; 2,3-dihydro-5,6-dimethoxy-2-(4-pyridinylmethylene)-1h-inden-1-one

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 499.9±45.0 °C at 760 mmHg
• 熔点: 210-211ºC
• 分子式: C₁₇H₁₅NO₃
• 分子量: 281.306
• 闪点: 256.1±28.7 °C
• 精确质量: 281.105194
• PSA: 48.42000
• LogP: 2.62
• 外观性状: 固体
• 蒸汽压: 0.0±1.3 mmHg at 25°C
• 折射率: 1.639
• 储存条件: Refrigerator

安全

• 危害码 (欧洲): Xi

合成路线

872-85-5 2107-69-9 ~98% 4803-74-1

文献：PIRAMAL HEALTHCARE LIMITED; GURUSAMY, Renugadevi; ROY, Mita; SHANMUGANATHAN, Ramasubramanian; JAGTAP, Ashutosh; HARIHARAN, Sivaramakrishnan; MISHRA, Sushil, Kumar; WANKHEDE, Karuna Patent: WO2012/131540 A1, 2012 ; Location in patent: Page/Page column 16 ;

872-85-5 2747-08-2 ~% 4803-74-1

文献：Dubey, Shailendra Kumar; Kharbanda, Manita; Dubey, Sushil Kumar; Mathela, Chandra Shekhar Chemical and Pharmaceutical Bulletin, 2010 , vol. 58, # 9 p. 1157 - 1160

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