211563-40-5

• 常用中文名：依法韦仑杂质10
• 常用英文名：[4-Chloro-2-[(1S)-3-cyclopropyl-1-hydroxy-1-(trifluoromethyl)-2-propynyl)phenyl]carbamic Acid Methyl Ester
• CAS号：211563-40-5
• 分子式：C₁₅H₁₃ClF₃NO₃
• 分子量：347.71700
• 发布时间：2016-04-21 10:59:08
• 更新时间：2026-08-05 22:49:20

名称

• 中文名: 依法韦仑杂质10
• 英文名: [4-Chloro-2-[(1S)-3-cyclopropyl-1-hydroxy-1-(trifluoromethyl)-2-propynyl)phenyl]carbamic Acid Methyl Ester
• 中文别名: 依法韦仑杂质8(依法韦仑IP杂质H); 依法韦伦氨基醇甲基氨基甲酸酯; 依法韦伦杂质H; 依法韦仑氨基醇甲基氨基甲酸酯; 依法韦仑杂质H; 4-氯-2-[(1S)-3-环丙基-1-羟基-1-(三氟甲基)-2-丙炔基)苯基]氨基甲酸甲酯; 依非韦伦杂质8; 依非韦伦杂质H
• 英文别名: Cbamic acid, N-[4-chloro-2-[(1S)-3-cyclopropyl-1-hydroxy-1-(trifluoromethyl)-2-propyn-1-yl]phenyl]-, methyl ester; Efavirenz IP Impurity H (Efavirenz Amino Alcohol Methyl Cbamate); Efavirenz Amino Alcohol Methyl Cbamate; Efavirenz Impurity 10; Methyl [4-chloro-2-((1S)-1-trifluoromethyl-1-hydroxy-3-cyclopropyl-2-propyn-1-yl)phenyl]cbamate; SD573-Methyl Carbamate,SV993; SD573-Methyl Cbamate, SV993; Efavirenz IP Impurity H; Efavirenx 10; Efavirenz amino alcohol methylcbomate; [4-Chloro-2-[(1S)-3-cyclopropyl-1-hydroxy-1-(trifluoromethyl)-2-propynyl)phenyl]cbamic Acid Methyl; [4-Chloro-2-[(1S)-3-cyclopropyl-1-hydroxy-1-(trifluoromethyl)-2-propynyl)phenyl]cbamic Acid Methyl Ester; Efavirenz IP Imp H; Efavirenz Impurity 8(Efavirenz IP Impurity H); Methyl [4-chloro-2-((1S)-1-trifluoromethyl-1-hydroxy-3-cyclopropyl-2-propyn-1-yl)phenyl]carbamate; Efavirenz Impurity H

物化性质

• 密度: 1.56g/cm3
• 沸点: 427.446ºC at 760 mmHg
• 分子式: C₁₅H₁₃ClF₃NO₃
• 分子量: 347.71700
• 闪点: 212.312ºC
• 精确质量: 347.05400
• PSA: 58.56000
• LogP: 3.75460
• 蒸汽压: 0mmHg at 25°C
• 折射率: 1.58

合成路线

79-22-1 209414-27-7 ~92% 211563-40-5

文献：MERCK and CO., INC. Patent: EP968197 B1, 2005 ; Location in patent: Page/Page column 16 ;

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