95-04-5

• 常用中文名：依克替脲
• 常用英文名：ectylurea
• CAS号：95-04-5
• 分子式：C₇H₁₂N₂O₂
• 分子量：156.18200
• 相关类别： 原料药 神经系统用药 抗焦虑药
• 发布时间：2018-09-29 10:34:33
• 更新时间：2024-01-10 18:05:38
• 癸酰脲是一种N-酰脲,可用于研究紧张和焦虑症状,对植物神经系统没有影响,对动物没有惊厥、镇痛或解痉作用[1]。

名称

• 中文名: 依克替脲
• 英文名: 2-Butenamide,N-(aminocarbonyl)-2-ethyl-, (2Z)
• 英文别名: cis-2-Ethyl-crotonylharnstoff; Levanil; 2-Ethylcrotonylurea; Astyn; N-<2-Ethyl-cis-crotonyl>-harnstoff; 2-Ethyl-cis-crotonylurea; ectylurea

物化性质

• 密度: 1.082g/cm3
• 沸点: 280.42°C (rough estimate)
• 熔点: 198°, also reported as mp 191-193° (lower melting form, mp 158°)
• 分子式: C₇H₁₂N₂O₂
• 分子量: 156.18200
• 精确质量: 156.09000
• PSA: 72.19000
• LogP: 1.62880
• 折射率: 1.488

生物活性

• 描述: 癸酰脲是一种N-酰脲,可用于研究紧张和焦虑症状,对植物神经系统没有影响,对动物没有惊厥、镇痛或解痉作用[1]。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 体内研究: 癸脲(0-500 mg/kg,i.p.,一次,20分钟)可以剂量依赖性方式显著引起小鼠运动协调的改变[2]。动物模型：雄性白化瑞士小鼠(18-23 g)[2]剂量：0、100、250和500 mg/kg给药：腹膜内注射,20分钟结果：以剂量依赖性方式影响幼鼠对加速旋转体的性能。

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : YT2800000 CHEMICAL NAME : Urea, (2-ethylcrotonoyl)-, (Z)- CAS REGISTRY NUMBER : 95-04-5 LAST UPDATED : 199707 DATA ITEMS CITED : 9 MOLECULAR FORMULA : C7-H12-N2-O2 MOLECULAR WEIGHT : 156.21 WISWESSER LINE NOTATION : ZVMVY2&U2 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : MEIEDD Merck Index. (Merck & Co., Inc., Rahway, NJ 07065) 10th ed. 1983. For publisher information, see 85KYAH. Volume(issue)/page/year: 10,507,1983 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 900 mg/kg TOXIC EFFECTS : Behavioral - sleep Behavioral - somnolence (general depressed activity) REFERENCE : FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 12,357,1953 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 14,845,1959 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1780 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,425,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 2800 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - antipsychotic Gastrointestinal - nausea or vomiting REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 114,418,1958 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 900 mg/kg TOXIC EFFECTS : Behavioral - sleep Behavioral - somnolence (general depressed activity) REFERENCE : FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 12,357,1953 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 1200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,425,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 1400 mg/kg TOXIC EFFECTS : Behavioral - sleep Behavioral - somnolence (general depressed activity) REFERENCE : FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 12,357,1953 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 1100 mg/kg TOXIC EFFECTS : Behavioral - sleep Behavioral - somnolence (general depressed activity) REFERENCE : FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 12,357,1953

安全

• 海关编码: 2924210090

合成路线

77-65-6 ~% 95-04-5

文献：Miles Labor. Inc. Patent: US2854379 , 1956 ; Full Text Show Details Miles Labor. Inc. Patent: DE948153 , 1953 ; Full Text Show Details Fancher; Lim Archives Internationales de Pharmacodynamie et de Therapie, 1958 , vol. 114, p. 418,419

26074-53-3 ~% 95-04-5

文献：Roehnert,H. Journal fuer Praktische Chemie (Leipzig), 1966 , vol. 32, p. 265 - 273

上下游产品

上游产品  2
77-65-6 26074-53-3
下游产品  0

海关

海关编码	2924210090
中文概述	2924210090 其他酰脲及其衍生物以及它们的盐。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%
申报要素	品名, 成分含量, 用途, 包装
Summary	2924210090 other ureines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%