95-04-5

95-04-5 structure

Name: ectylurea
Chemical Name: 2-Butenamide,N-(aminocarbonyl)-2-ethyl-, (2Z)
CAS Number: 95-04-5
Molecular Formula: C₇H₁₂N₂O₂
Molecular Weight: 156.18200
Catalog: API Nervous system medication Anxiolytic
Create Date: 2018-09-29 10:34:33
Modify Date: 2024-01-10 18:05:38
Ectylurea，a N-acylurea，can be used in studies of tension and anxiety symptoms, has no effect on the autonomic nervous system, and has no convulsive, analgesic or antispasmodic activity in animals[1].

Name	2-Butenamide,N-(aminocarbonyl)-2-ethyl-, (2Z)
Synonyms	cis-2-Ethyl-crotonylharnstoff Levanil 2-Ethylcrotonylurea Astyn N-<2-Ethyl-cis-crotonyl>-harnstoff 2-Ethyl-cis-crotonylurea ectylurea

Description	Ectylurea，a N-acylurea，can be used in studies of tension and anxiety symptoms, has no effect on the autonomic nervous system, and has no convulsive, analgesic or antispasmodic activity in animals[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vivo	Ectylurea (0-500 mg/kg, i.p., once, 20 min) can significantly cause changes in motor coordination in mice in a dose dependent manner[2]. Animal Model: Male albino Swiss mice (18-23 g)[2] Dosage: 0, 100, 250 and 500 mg/kg Administration: Intraperitoneal injection, 20 min Result: Influenced on the performance of naive mice on the accelerating rotarod in a dose dependent manner.

Density	1.082g/cm3
Boiling Point	280.42°C (rough estimate)
Melting Point	198°, also reported as mp 191-193° (lower melting form, mp 158°)
Molecular Formula	C₇H₁₂N₂O₂
Molecular Weight	156.18200
Exact Mass	156.09000
PSA	72.19000
LogP	1.62880
Index of Refraction	1.488

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YT2800000

CHEMICAL NAME :: Urea, (2-ethylcrotonoyl)-, (Z)-

CAS REGISTRY NUMBER :: 95-04-5

LAST UPDATED :: 199707

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C7-H12-N2-O2

MOLECULAR WEIGHT :: 156.21

WISWESSER LINE NOTATION :: ZVMVY2&U2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MEIEDD Merck Index. (Merck & Co., Inc., Rahway, NJ 07065) 10th ed. 1983. For publisher information, see 85KYAH. Volume(issue)/page/year: 10,507,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Behavioral - sleep Behavioral - somnolence (general depressed activity)

REFERENCE :: FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 12,357,1953

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 14,845,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1780 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,425,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 2800 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - antipsychotic Gastrointestinal - nausea or vomiting

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 114,418,1958

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Behavioral - sleep Behavioral - somnolence (general depressed activity)

REFERENCE :: FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 12,357,1953

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,425,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1400 mg/kg

TOXIC EFFECTS :: Behavioral - sleep Behavioral - somnolence (general depressed activity)

REFERENCE :: FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 12,357,1953

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1100 mg/kg

TOXIC EFFECTS :: Behavioral - sleep Behavioral - somnolence (general depressed activity)

REFERENCE :: FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 12,357,1953

HS Code	2924210090

77-65-6

95-04-5

Literature: Miles Labor. Inc. Patent: US2854379 , 1956 ; Full Text Show Details Miles Labor. Inc. Patent: DE948153 , 1953 ; Full Text Show Details Fancher; Lim Archives Internationales de Pharmacodynamie et de Therapie, 1958 , vol. 114, p. 418,419

26074-53-3

95-04-5

Literature: Roehnert,H. Journal fuer Praktische Chemie (Leipzig), 1966 , vol. 32, p. 265 - 273

Precursor 2
77-65-6 26074-53-3
DownStream 0

HS Code	2924210090
Summary	2924210090 other ureines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

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