1197811-72-5

• 常用中文名：2-(4-羟基苄基)-N,5-二-(4-氟苯基)-5-羟基戊酰胺
• 常用英文名：2-(4-Hydroxybenzyl)-N,5-bis-(4-fluorophenyl)-5-hydroxypentanamide
• CAS号：1197811-72-5
• 分子式：C₂₄H₂₃F₂NO₃
• 分子量：411.44100
• 发布时间：2016-06-22 10:09:29
• 更新时间：2026-08-04 14:12:13

名称

• 中文名: 2-(4-羟基苄基)-N,5-二-(4-氟苯基)-5-羟基戊酰胺
• 英文名: 2-(4-Hydroxybenzyl)-N,5-bis-(4-fluorophenyl)-5-hydroxypentanamide
• 中文别名: 依泽替米贝环开放杂质; (2R,5S)-N,5-双(4-氟苯基)-5-羟基-2-(4-羟基苄基)戊酰胺; 依替米贝开环杂质; 依折麦布杂质114(开环杂质); 依折麦布开环杂质; 依折麦布开环酰胺杂质; 依折麦布开环杂质对照品; 依折麦布杂质ABCDEFGHIJK; 依折麦布环开杂质; 依折麦布杂质; (2R,5S)-N,5-双(4-氟苯基)-5-羟基-2-(4-羟基苄基)戊酰胺(依折麦布杂质); 依折麦布杂质B; 依泽替米贝开环杂质
• 英文别名: (2R,5S)-N,5-bis(4-fluorophenyl); (2R,5S)-N,5-bis(4-fluorophenyl)-5-hydroxy-2-(4-hydroxybenzyl)pentanamide (Ezetimibe Impurity）; Ezetimibe Impurity 114 (Ring-Open Impurity); Ezetimibe Ring Opened Impurity; (αR,δS)-4-Fluoro-N-(4-fluorophenyl)-δ-hydroxy-α-[(4-hydroxyphenyl)Methyl]benzenentanaMide; Ezetimibe Open-Ring Amide Impurity; N,5-Bis(4-fluorophenyl)-5-hydroxy-2-(4-hydroxybenzyl)pentanamide; Ring opened ezetimibe impurity; (2R,5S)-2-(4-Hydroxybenzyl)-N,5-bis(4-fluorophenyl)-5-hydroxypentanamide; (5S)-N,5-BIS(4-FLUOROPHENYL)-5- HYDROXYPENTAMIDE; Ezetimibe Impurity 13(Open Ring Impurity); EzetiMibe Ring-opening IMpurity; (αR,δS)-4-Fluoro-N-(4-fluorophenyl)-δ-hydroxy-α-[(4-hydroxyphenyl)Methyl]benzenepentanaMide; (2R,5S)-N,5-bis(4-fluorophenyl)-5-hydroxy-2-(4-hydroxybenzyl)pentanaMide; Ezetimibe-2; Ezetimibe Impuriry B; Benzenentanamide, 4-fluoro-N-(4-fluorophenyl)-δ-hydroxy-α-[(4-hydroxyphenyl)methyl]-, (αR,δS); Ezetimibe Ring-Open Impurity; Ezetimibe impuriry 5/Ezetimibe Ring-Open Impurity/(2R,5S)-N,5-bis(4-fluorophenyl)-5-hydroxy-2-(4-hydroxybenzyl)pentanamide; (2R,5S)-N,5-bis(4-fluorophenyl)-5-hydroxy-2-[(4-hydroxyphenyl)methyl]pentanamide; Ezetimibe Amide impurity; 2-(4-Hydroxybenzyl)-N,5-bis-(4-fluorophenyl)-5-hydroxypentanaMide

物化性质

• 分子式: C₂₄H₂₃F₂NO₃
• 分子量: 411.44100
• 精确质量: 411.16500
• PSA: 69.56000
• LogP: 5.05460

合成路线

163222-32-0 ~% 1197811-72-5 163222-33-1

文献：Lek Pharmaceuticals D.D. Patent: EP2128133 A1, 2009 ; Location in patent: Page/Page column 5-6 ;

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