163222-32-0

• 常用中文名：4'-O-苄氧依折麦布
• 常用英文名：4'-O-Benzyloxy Ezetimibe
• CAS号：163222-32-0
• 分子式：C₃₁H₂₇F₂NO₃
• 分子量：499.548
• 发布时间：2018-12-31 19:41:50
• 更新时间：2026-07-01 09:56:28

名称

• 中文名: (3R,4S)-1-(4-氟苯基)-3-[(3S)-3-(4-氟苯基)-3-羟基丙基]-4-[4-(苯甲氧基)苯基]-2-氮杂环丁酮
• 英文名: 4'-O-Benzyloxy Ezetimibe
• 中文别名: R890440,(3R,4S)-1-(4-氟苯基)-3-[(3S)-3-(4-氟苯基)-3-羟基丙基]-4-[4-(苯甲氧基)苯基]-2-氮杂环丁酮; (3R,4S)-1-(4-氟苯基)-3-[(3S)-3-(4-氟苯基)-3-羟丙基]-4-(4-苄氧苯基)-2-氮杂环丁酮; 4′-O-苄基依折麦布; 依折麦布中间体2; (3R,4s)-1-(4-氟苯基)-3-[(3s)-3-(4-氟苯基)-3-羟基丙基]-4-[4-(苯基甲氧基)苯基]-2-氮杂啶酮; 依折麦布中间体ZTB-8; 依折麦布苄基杂质; 1-(4氟苯基)-3-[3-(4氟苯基)-3-羟丙基]-4-(4苄氧苯基)-2-氮杂环丁酮; 依泽替米贝杂质,EZ-IMP-8; (3R,4S)-4-[4-(苄氧基)苯基]-1-(4-氟苯基)-3-[(S)-3-(4-氟苯基)-3-羟基丙基]氮杂环丁烷-2-酮; 依泽替米贝苄醚杂质; 1-苯基-(3R-[3-(4-氟苯基-(3S-羟丙基]-(4S-(4-羟苯基-2-氮杂环丁酮; 依替米贝中间体N; 4'-邻苄基依折麦布; (3R,4S)-4-(4-(苄氧基)苯基)-1-(4-氟苯基)-3-((S)-3-(4-氟苯)-3-羟丙基)氮杂环丁烷-2-酮; 依折麦布中间体6; 4'-O-苄基依泽替米贝; 4 '-O-苄基依折麦布; 依折麦布中级杂质
• 英文别名: 4’-O-Benzyl Ezetimibe; 1-Phenyl-3R-[3-(4-Fluorophenyl-3S-Hydroxypropyl]-4S-(4-Hydroxyphenyl-AzetidiN-2-One; (3R,4S)-1-(4-FLUOROPHENYL)-3-[(3S)-3-(4-FLUORO; EzetimibeBenzyl Ether Impurity; me: 2-AZETIDINONE, 1-(4-FLUOROPHENYL)-3-[(3S)-3-(4-FLUOROPHENYL)-3-HYDROXYPROPYL]-4-[4-(PHENYLMETHOXY)PHENYL]-, (3R,4S); 1-(4-F; Ezetimibe Intermediate-L; Ezetimibe Benzyl; 1-(4-FLUOROPHENYL)-3-[(3S)-3-(4-FLUOROPHENYL)-3-HYDROXYPROPYL]-4-[4-(PHENYLMETHOXY)PHENYL]-, (3R,4S)-2-AZETIDINONE; 4'-O-Benzyl EzetiMibe; (3R,4S)-4-(4-(benzyloxy)phenyl)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3'-hydroxypropyl)azetidin-2-one; (3R,4S)-4-(4-(Benzyloxy)phenyl)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)azetidin-2-one (Intermediate of Ezetimibe); (3R)-3-[1-(benzyloxy)cyclohexa-2,4-dien-1-yl]-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]azetidin-2-one; ZTB-8 min; 1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-phenylmethoxyphenyl)-2-azetidinone; EZETIMIBE BENZYL ESTER; (3R,4S)-4-[(4-Benzyloxy)phenyl]-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-2-azetidinone; Ezetimibe intermediate 2; (3R,4S)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)- 3(S)-hydroxypropyl]-4-(4-benzyloxyphenyl)-2-azetidinone; Ezetimibe Impurity 16; (3R,4S)-1-(4-Fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-[4-(phenylmethoxy)phenyl]-2-azetidinone; 1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-[4-phenylmethoxy]phenyl]-(3R,4S)-2-azetidinone (intermediate of ezetimibe); (3R,4S)-1-(4-Fluorophenyl)-3-[(3S)-3-(4-Fluorophenyl)-3-Hydroxypropyl]-4-[4-(Phenylmethoxy)phenyl]-Azetidinone; Benzylated Ezetimibe; ZTB-8; Azetidinone, 1-(4-Fluorophenyl)-3-[(3S)-3-(4-Fluorophenyl)-3; EZ-ETL; EzetiMibe Benzyl IMpurity; E7:synthesis of trans-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxypropyl-(4-benzyloxyphenyl)]-2-azetidinone; Ezetimibe Impurity 14(Intermediate Impurity); (3R,4S)-4-[4-(Benzyloxy)phenyl]-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]azetidin-2-one; Azetidinone, 1-(4-Fluorophenyl)-3-[(3S)-3-(4-Fluorophenyl)-3-Hydroxypropyl]-4-[4-(PhenylMethoxy)phenyl]-, (3R,4S); (3R,4S)-4-(4-(Benzyloxy)Phenyl)-1-(4-Fluorophenyl)-3-((S)-3-(4- Fluorophenyl)-3-Hydroxypropyl)Azetidin-2-One ISO 9001：2015 REACH; 4’-O-Benzyloxy Ezetimibe; 2-AZETIDINONE, 1-(4-FLUOROPHENYL)-3-[(3S)-3-(4-FLUOROPHENYL)-3-HYDROXYPROPYL]-4-[4-(PHENYLMETHOXY)PHENYL]-, (3R,4S); (3R,4S)-1-(4-Fluorophenyl)-3-(3S)-3-(4-fluorophenyl)-3-hydroxy-propyl-(benzyloxy)phenyl-2-azetidinone; (3R,4S)-4-[4-(Benzyloxy)phenyl]-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-2-azetidinone; (3R,4S)-4-(4-(benzyloxy)phenyl)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)azetidin-2-one; 1-(4-Fluorophenyl)-3-[(3s)-3-(4-Fluorophenyl)-3-Hydroxypropyl]-4-[4-(Phenylmethoxy)Phenyl-(3r,4s)-2-Azetidinone

物化性质

• 密度: 1.270
• 沸点: 706.5±60.0 °C at 760 mmHg
• 分子式: C₃₁H₂₇F₂NO₃
• 分子量: 499.548
• 闪点: 381.1±32.9 °C
• 精确质量: 499.195892
• PSA: 49.77000
• LogP: 5.56
• 外观性状: 灰白色固体
• 蒸汽压: 0.0±2.4 mmHg at 25°C
• 折射率: 1.617
• 储存条件: 室温，干燥密封

合成路线

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