197142-34-0

• 常用中文名：(1R,3S,5R)-2-(叔丁氧基羰基)-2-氮杂双环[3.1.0]己烷-3-羧酸
• 常用英文名：N-Boc-L-trans-4,5-methanoproline
• CAS号：197142-34-0
• 分子式：C₁₁H₁₇NO₄
• 分子量：227.257
• 发布时间：2018-12-31 12:53:21
• 更新时间：2024-01-12 18:02:59

名称

• 中文名: N-叔丁氧羰基-L-反-2-氮杂二环[3.1.0]己烷-3-羧酸
• 英文名: (1R,3S,5R)-2-[(2-methylpropan-2-yl)oxycarbonyl]-2-azabicyclo[3.1.0]hexane-3-carboxylic acid
• 英文别名: (1R,3S,5R)-2-{[(2-Methyl-2-propanyl)oxy]carbonyl}-2-azabicyclo[3.1.0]hexane-3-carboxylic acid; N-Boc-L-trans-4,5-methanoproline; (1R,3S,5R)-2-(tert-butoxycarbonyl)-2-azabicyclo[3.1.0]hexane-3-carboxylic acid; (1R,3S,5R)-2-aza-bicyclo[3.1.0]hexane-2,3-dicarboxylic acid 2-tert-butyl ester; 2-Azabicyclo[3.1.0]hexane-2,3-dicarboxylic acid, 2-(1,1-dimethylethyl) ester, (1R,3S,5R)-; (1R,3S,5R)-2-tert-butoxycarbonyl-2-azabicyclo[3.1.0]hexane-3-carboxylic acid; (4R,5R)-metano-N-Boc-L-proline

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 355.9±25.0 °C at 760 mmHg
• 分子式: C₁₁H₁₇NO₄
• 分子量: 227.257
• 闪点: 169.0±23.2 °C
• 精确质量: 227.115753
• PSA: 66.84000
• LogP: 0.41
• 蒸汽压: 0.0±1.7 mmHg at 25°C
• 折射率: 1.537
• 储存条件: 2-8°C，干燥密封

合成路线

197142-33-9 ~75% 197142-34-0

文献：Hanessian, Stephen; Reinhold, Ulrich; Gentile, Gabriella Angewandte Chemie (International Edition in English), 1997 , vol. 36, # 17 p. 1881 - 1884

24424-99-5 1312338-82-1 ~76% 197142-34-0

文献：BRISTOL-MYERS SQUIBB COMPANY; PACK, Shawn, K.; TYMONKO, Steven; PATEL, Bharat, P.; NATALIE, JR., Kenneth, J.; BELEMA, Makonen Patent: WO2011/59850 A1, 2011 ; Location in patent: Page/Page column 179-180 ;

1208008-34-7 ~60% 197142-34-0

文献：BRISTOL-MYERS SQUIBB COMPANY; PACK, Shawn, K.; TYMONKO, Steven; PATEL, Bharat, P.; NATALIE, JR., Kenneth, J.; BELEMA, Makonen Patent: WO2011/59850 A1, 2011 ; Location in patent: Page/Page column 178-179 ;

138629-30-8 ~% 197142-34-0

文献：Hanessian, Stephen; Reinhold, Ulrich; Gentile, Gabriella Angewandte Chemie (International Edition in English), 1997 , vol. 36, # 17 p. 1881 - 1884

132974-83-5 ~% 197142-34-0

文献：BRISTOL-MYERS SQUIBB COMPANY; PACK, Shawn, K.; TYMONKO, Steven; PATEL, Bharat, P.; NATALIE, JR., Kenneth, J.; BELEMA, Makonen Patent: WO2011/59850 A1, 2011 ;

17342-08-4 ~% 197142-34-0

文献：BRISTOL-MYERS SQUIBB COMPANY; PACK, Shawn, K.; TYMONKO, Steven; PATEL, Bharat, P.; NATALIE, JR., Kenneth, J.; BELEMA, Makonen Patent: WO2011/59850 A1, 2011 ;

98-79-3 ~% 197142-34-0

文献：BOEHRINGER INGELHEIM INTERNATIONAL GMBH; THIBEAULT, Carl; EDWARDS, Paul, J.; KUHN, Cyrille; MOREAU, BenoIt; POIRIER, Maude; SURPRENANT, Simon Patent: WO2012/48421 A1, 2012 ;

7149-65-7 ~% 197142-34-0

文献：BOEHRINGER INGELHEIM INTERNATIONAL GMBH; THIBEAULT, Carl; EDWARDS, Paul, J.; KUHN, Cyrille; MOREAU, BenoIt; POIRIER, Maude; SURPRENANT, Simon Patent: WO2012/48421 A1, 2012 ;

1208008-33-6 ~% 197142-34-0

文献：BRISTOL-MYERS SQUIBB COMPANY; PACK, Shawn, K.; TYMONKO, Steven; PATEL, Bharat, P.; NATALIE, JR., Kenneth, J.; BELEMA, Makonen Patent: WO2011/59850 A1, 2011 ;