(1R,3S,5R)-2-(叔丁氧基羰基)-2-氮杂双环[3.1.0]己烷-3-羧酸

更新时间：2025-08-25 12:37:26

(1R,3S,5R)-2-(叔丁氧基羰基)-2-氮杂双环[3.1.0]己烷-3-羧酸结构式	常用名	(1R,3S,5R)-2-(叔丁氧基羰基)-2-氮杂双环[3.1.0]己烷-3-羧酸	英文名	N-Boc-L-trans-4,5-methanoproline
	CAS号	197142-34-0	分子量	227.257
	密度	1.3±0.1 g/cm3	沸点	355.9±25.0 °C at 760 mmHg
	分子式	C₁₁H₁₇NO₄	熔点	N/A
	MSDS	N/A	闪点	169.0±23.2 °C

中文名	N-叔丁氧羰基-L-反-2-氮杂二环[3.1.0]己烷-3-羧酸
英文名	(1R,3S,5R)-2-[(2-methylpropan-2-yl)oxycarbonyl]-2-azabicyclo[3.1.0]hexane-3-carboxylic acid
英文别名	更多

密度	1.3±0.1 g/cm3
沸点	355.9±25.0 °C at 760 mmHg
分子式	C₁₁H₁₇NO₄
分子量	227.257
闪点	169.0±23.2 °C
精确质量	227.115753
PSA	66.84000
LogP	0.41
InChIKey	VXIIZQXOIDYWBS-PRJMDXOYSA-N
SMILES	CC(C)(C)OC(=O)N1C(C(=O)O)CC2CC21
蒸汽压	0.0±1.7 mmHg at 25°C
折射率	1.537
储存条件	2-8°C，干燥密封

tert-butyl (3S)...

197142-33-9

~75%

(1R,3S,5R)-2-(叔...

197142-34-0

文献：Hanessian, Stephen; Reinhold, Ulrich; Gentile, Gabriella Angewandte Chemie (International Edition in English), 1997 , vol. 36, # 17 p. 1881 - 1884

二碳酸二叔丁酯

24424-99-5

沙格列汀杂质34

1312338-82-1

~76%

(1R,3S,5R)-2-(叔...

197142-34-0

文献：BRISTOL-MYERS SQUIBB COMPANY; PACK, Shawn, K.; TYMONKO, Steven; PATEL, Bharat, P.; NATALIE, JR., Kenneth, J.; BELEMA, Makonen Patent: WO2011/59850 A1, 2011 ; Location in patent: Page/Page column 179-180 ;

(3S)-3-((tert-b...

1208008-34-7

~60%

(1R,3S,5R)-2-(叔...

197142-34-0

(2R)-2-[[[(1,1-...

138629-30-8

(1R,3S,5R)-2-(叔...

197142-34-0

文献：Hanessian, Stephen; Reinhold, Ulrich; Gentile, Gabriella Angewandte Chemie (International Edition in English), 1997 , vol. 36, # 17 p. 1881 - 1884

(2S)-2-[[[(1,1-...

132974-83-5

(1R,3S,5R)-2-(叔...

197142-34-0

文献：BRISTOL-MYERS SQUIBB COMPANY; PACK, Shawn, K.; TYMONKO, Steven; PATEL, Bharat, P.; NATALIE, JR., Kenneth, J.; BELEMA, Makonen Patent: WO2011/59850 A1, 2011 ;

L-焦谷氨醇

17342-08-4

(1R,3S,5R)-2-(叔...

197142-34-0

文献：BRISTOL-MYERS SQUIBB COMPANY; PACK, Shawn, K.; TYMONKO, Steven; PATEL, Bharat, P.; NATALIE, JR., Kenneth, J.; BELEMA, Makonen Patent: WO2011/59850 A1, 2011 ;

L-焦谷氨酸

98-79-3

(1R,3S,5R)-2-(叔...

197142-34-0

文献：BOEHRINGER INGELHEIM INTERNATIONAL GMBH; THIBEAULT, Carl; EDWARDS, Paul, J.; KUHN, Cyrille; MOREAU, BenoIt; POIRIER, Maude; SURPRENANT, Simon Patent: WO2012/48421 A1, 2012 ;

L-焦谷氨酸乙酯

7149-65-7

(1R,3S,5R)-2-(叔...

197142-34-0

文献：BOEHRINGER INGELHEIM INTERNATIONAL GMBH; THIBEAULT, Carl; EDWARDS, Paul, J.; KUHN, Cyrille; MOREAU, BenoIt; POIRIER, Maude; SURPRENANT, Simon Patent: WO2012/48421 A1, 2012 ;

(3S)-tert-butyl...

1208008-33-6

(1R,3S,5R)-2-(叔...

197142-34-0

文献：BRISTOL-MYERS SQUIBB COMPANY; PACK, Shawn, K.; TYMONKO, Steven; PATEL, Bharat, P.; NATALIE, JR., Kenneth, J.; BELEMA, Makonen Patent: WO2011/59850 A1, 2011 ;

(1R,3S,5R)-2-{[(2-Methyl-2-propanyl)oxy]carbonyl}-2-azabicyclo[3.1.0]hexane-3-carboxylic acid

N-Boc-L-trans-4,5-methanoproline

(1R,3S,5R)-2-(tert-butoxycarbonyl)-2-azabicyclo[3.1.0]hexane-3-carboxylic acid

(1R,3S,5R)-2-aza-bicyclo[3.1.0]hexane-2,3-dicarboxylic acid 2-tert-butyl ester

(1R,3S,5R)-2-tert-butoxycarbonyl-2-azabicyclo[3.1.0]hexane-3-carboxylic acid

(4R,5R)-metano-N-Boc-L-proline