331002-70-1

• 常用中文名：PT 1
• 常用英文名：PT 1
• CAS号：331002-70-1
• 分子式：C₂₃H₁₆ClN₃O₆S
• 分子量：497.90800
• 发布时间：2016-06-17 07:12:35
• 更新时间：2024-01-10 11:05:31
• PT1是一种AMPKα1激活剂,可直接激活AMPKα1单体的非活性截短形式[1]。

名称

• 英文名: 2-Chloro-5-{(Z)-[(5Z)-5-{[5-(4,5-dimethyl-2-nitrophenyl)-2-furyl] methylene}-4-oxo-1,3-thiazolidin-2-ylidene]amino}benzoic acid
• 英文别名: 2-CHLORO-5-(6-METHOXY-7-(2-METHOXYETHOXY)QUINAZOLIN-4-YLAMINO)CYCLOHEXA-2,5-DIENE-1,4-DIONE; 2-chloro-5-{5-[5-(4,5-dimethyl-2-nitro-phenyl)-furan-2-ylmethylene]-4-oxo-thiazolidin-2-ylideneamino}-benzoic acid; 2-chloro-5-{[6-methoxy-7-(2-methoxyethoxy)quinazolin-4-yl]amino}benzo-1,4-quinone

物化性质

• 分子式: C₂₃H₁₆ClN₃O₆S
• 分子量: 497.90800
• 精确质量: 497.04500
• PSA: 166.51000
• LogP: 6.51390

生物活性

• 描述: PT1是一种AMPKα1激活剂,可直接激活AMPKα1单体的非活性截短形式[1]。
• 相关类别:
  信号通路 >> 表观遗传学 >> AMPK
  研究领域 >> 心血管疾病
  信号通路 >> PI3K/Akt/mTOR 信号通路 >> AMPK
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Pang T, et al. Small molecule antagonizes autoinhibition and activates AMP-activated protein kinase in cells. J Biol Chem. 2008 Jun 6;283(23):16051-60.

安全

• 危险品运输编码: NONH for all modes of transport

合成路线

1242840-80-7 1266374-59-7 ~51% 331002-70-1

文献：Yu, Li-Fang; Li, Yuan-Yuan; Su, Ming-Bo; Zhang, Mei; Zhang, Wei; Zhang, Li-Na; Pang, Tao; Zhang, Run-Tao; Liu, Bing; Li, Jing-Ya; Li, Jia; Nan, Fa-Jun ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 5 p. 475 - 480

89-54-3 ~% 331002-70-1

文献：Yu, Li-Fang; Li, Yuan-Yuan; Su, Ming-Bo; Zhang, Mei; Zhang, Wei; Zhang, Li-Na; Pang, Tao; Zhang, Run-Tao; Liu, Bing; Li, Jing-Ya; Li, Jia; Nan, Fa-Jun ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 5 p. 475 - 480

6972-71-0 ~% 331002-70-1

文献：Yu, Li-Fang; Li, Yuan-Yuan; Su, Ming-Bo; Zhang, Mei; Zhang, Wei; Zhang, Li-Na; Pang, Tao; Zhang, Run-Tao; Liu, Bing; Li, Jing-Ya; Li, Jia; Nan, Fa-Jun ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 5 p. 475 - 480

88-14-2 ~% 331002-70-1

文献：Yu, Li-Fang; Li, Yuan-Yuan; Su, Ming-Bo; Zhang, Mei; Zhang, Wei; Zhang, Li-Na; Pang, Tao; Zhang, Run-Tao; Liu, Bing; Li, Jing-Ya; Li, Jia; Nan, Fa-Jun ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 5 p. 475 - 480

1270120-16-5 ~% 331002-70-1

文献：Yu, Li-Fang; Li, Yuan-Yuan; Su, Ming-Bo; Zhang, Mei; Zhang, Wei; Zhang, Li-Na; Pang, Tao; Zhang, Run-Tao; Liu, Bing; Li, Jing-Ya; Li, Jia; Nan, Fa-Jun ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 5 p. 475 - 480

上下游产品

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1266374-59-7 89-54-3 6972-71-0 88-14-2
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