PT 1

Modify Date: 2026-07-01 15:56:42

PT 1 structure	Common Name	PT 1
	CAS Number	331002-70-1	Molecular Weight	497.90800
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₃H₁₆ClN₃O₆S	Melting Point	N/A
	MSDS	USA	Flash Point	N/A

Use of PT 1

PT1 is an AMPKα1 activator that directly activates the inactive truncated forms of AMPKα1 monomers[1].

Name	2-Chloro-5-{(Z)-[(5Z)-5-{[5-(4,5-dimethyl-2-nitrophenyl)-2-furyl] methylene}-4-oxo-1,3-thiazolidin-2-ylidene]amino}benzoic acid
Synonym	More Synonyms

Description	PT1 is an AMPKα1 activator that directly activates the inactive truncated forms of AMPKα1 monomers[1].
Related Catalog	Signaling Pathways >> Epigenetics >> AMPK Research Areas >> Cardiovascular Disease Signaling Pathways >> PI3K/Akt/mTOR >> AMPK Research Areas >> Metabolic Disease
References	[1]. Pang T, et al. Small molecule antagonizes autoinhibition and activates AMP-activated protein kinase in cells. J Biol Chem. 2008 Jun 6;283(23):16051-60.

Molecular Formula	C₂₃H₁₆ClN₃O₆S
Molecular Weight	497.90800
Exact Mass	497.04500
PSA	166.51000
LogP	6.51390
InChIKey	RTHRCOIONCZINZ-KEBDBYFISA-N
SMILES	Cc1cc(-c2ccc(C=C3SC(=Nc4ccc(Cl)c(C(=O)O)c4)NC3=O)o2)c([N+](=O)[O-])cc1C

RIDADR	NONH for all modes of transport

5-(2-nitro-4,5-dimethylphenyl)-2-furaldehyde structure

5-(2-nitro-4,5-...

CAS#:1242840-80-7

2-chloro-5-(4-oxo-thiazolidin-2-ylideneamino)-benzoic acid structure

2-chloro-5-(4-o...

CAS#:1266374-59-7

~51%

PT 1 Structure

PT 1

CAS#:331002-70-1

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Literature: Yu, Li-Fang; Li, Yuan-Yuan; Su, Ming-Bo; Zhang, Mei; Zhang, Wei; Zhang, Li-Na; Pang, Tao; Zhang, Run-Tao; Liu, Bing; Li, Jing-Ya; Li, Jia; Nan, Fa-Jun ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 5 p. 475 - 480

5-Amino-2-chlorobenzoic acid structure

5-Amino-2-chlor...

CAS#:89-54-3

~%

PT 1 Structure

PT 1

CAS#:331002-70-1

Learn More

Literature: Yu, Li-Fang; Li, Yuan-Yuan; Su, Ming-Bo; Zhang, Mei; Zhang, Wei; Zhang, Li-Na; Pang, Tao; Zhang, Run-Tao; Liu, Bing; Li, Jing-Ya; Li, Jia; Nan, Fa-Jun ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 5 p. 475 - 480

4,5-Dimethyl-2-nitroaniline structure

4,5-Dimethyl-2-...

CAS#:6972-71-0

~%

PT 1 Structure

PT 1

CAS#:331002-70-1

Learn More

Literature: Yu, Li-Fang; Li, Yuan-Yuan; Su, Ming-Bo; Zhang, Mei; Zhang, Wei; Zhang, Li-Na; Pang, Tao; Zhang, Run-Tao; Liu, Bing; Li, Jing-Ya; Li, Jia; Nan, Fa-Jun ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 5 p. 475 - 480

Furan-2-carboxylic acid structure

Furan-2-carboxy...

CAS#:88-14-2

~%

PT 1 Structure

PT 1

CAS#:331002-70-1

Learn More

Literature: Yu, Li-Fang; Li, Yuan-Yuan; Su, Ming-Bo; Zhang, Mei; Zhang, Wei; Zhang, Li-Na; Pang, Tao; Zhang, Run-Tao; Liu, Bing; Li, Jing-Ya; Li, Jia; Nan, Fa-Jun ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 5 p. 475 - 480

5-(4,5-dimethyl-2-nitro-phenyl)-furan-2-carboxylic acid structure

5-(4,5-dimethyl...

CAS#:1270120-16-5

~%

PT 1 Structure

PT 1

CAS#:331002-70-1

Learn More

Literature: Yu, Li-Fang; Li, Yuan-Yuan; Su, Ming-Bo; Zhang, Mei; Zhang, Wei; Zhang, Li-Na; Pang, Tao; Zhang, Run-Tao; Liu, Bing; Li, Jing-Ya; Li, Jia; Nan, Fa-Jun ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 5 p. 475 - 480

Precursor 4
CAS#:1266374-59-7 2-chloro-5-(4-o... CAS#:89-54-3 5-Amino-2-chlor... CAS#:6972-71-0 4,5-Dimethyl-2-... CAS#:88-14-2 Furan-2-carboxy...
DownStream 0

2-CHLORO-5-(6-METHOXY-7-(2-METHOXYETHOXY)QUINAZOLIN-4-YLAMINO)CYCLOHEXA-2,5-DIENE-1,4-DIONE

2-chloro-5-{5-[5-(4,5-dimethyl-2-nitro-phenyl)-furan-2-ylmethylene]-4-oxo-thiazolidin-2-ylideneamino}-benzoic acid

2-chloro-5-{[6-methoxy-7-(2-methoxyethoxy)quinazolin-4-yl]amino}benzo-1,4-quinone

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: PT 1
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Purity: 98.0%
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