500-55-0

• 常用中文名：阿朴阿托品
• 常用英文名：8-Methyl-8-azabicyclo[3.2.1]oct-3-yl atropate
• CAS号：500-55-0
• 分子式：C₁₇H₂₁NO₂
• 分子量：271.354
• 发布时间：2018-09-14 09:33:01
• 更新时间：2026-07-19 19:33:44

名称

• 中文名: 阿朴阿托品
• 英文名: (8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 2-phenylprop-2-enoate
• 中文别名: 變阿托品; 硫酸阿托品杂质A(莨菪碱杂质G); (1R,3r,5S)-8-甲基-8-氮杂双环[3.2.1]辛-3-基 2-苯基丙烯酸酯; 阿托品杂质A; 阿托品杂质1(阿托品杂质A); 莨菪碱杂质G; 變顛茄鹼; 去水阿托品; 杂质A(阿朴阿托品); (去水阿托品,管制药品); (3-内)-8-甲基-8-氮杂二环[3.2.1]辛-3-基 A-亚甲基苯乙酸酯
• 英文别名: 1-alpha-H,5-alpha-H-Tropan-3-alpha-ol, atropate; Apohyoscyamine; atropic acid tropane-3endo-yl ester; Atropine Impurity A HCl; Atropamin; (4S)-1,2,3,4-Tetrahydro-1-phenylnaphthalene-1,4-dicboxylic acid bis(8-methyl-8-azabicyclo[3.2.1]octan-3-yl) ester; Apoatropin; endo-alpha-Methylenebenzeneacetic acid 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester; α-Methylenebenzeneacetic acid [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3α-yl] ester; Atropine Impurity A; Detoxified atropine; Atropine Impurity A Apoatropine, 8-methyl-8-azabicyclo[3.2.1]octan-3-yl 2- phenylacrylate; Tropine, atropate; apotropine; endo-te; 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester; Apohyoscyamin; alpha-methylene-benzeneaceticaci8-methyl-8-azabicyclo(3.2.1)oct-3-yles; apohyoscyamin; 2-phenylacrylic acid (8-methyl-8-azabicyclo[3.2.1]octan-3-yl) ester; Benzeneacetic acid, a-methylene-,(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester; Atropine Impurity A (Hyoscyamine Impurity G, Apoatropine); 1-alpha-h,5-alpha-h-tropan-3-alpha-ol,atropate(ester); Tropic acid, 3-alpha-tropanyl ester; Tiotropium Impurity 18; ATROPYLTROPEINE; Benzenamine,8-hydrazinyl-N,N-dimethyl; endo-alpha-methylenebenzeneaceticacid8-methyl-8-azabicyclo(3.2.1)oct-3-yle; Atropasaeure-tropan-3endo-ylester; APOATROPINE; Atropyltropeine; Atropine Sulfate Impurity A(Hyoscine Impurity G); (4R)-1,2,3,4-Tetrahydro-1-phenylnaphthalene-1,4-dicboxylic acid bis(8-methyl-8-azabicyclo[3.2.1]octan-3-yl) ester; Atropic acid (1R,5S)-tropan-3α-yl ester; (1R,3r,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl2-phenylacrylate; Apoatropine (6CI, 7CI); APOHYOSCYAMINE; Benzeneacetic acid, α-methylene-, 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester; Propenoic acid, 2-phenyl-, 8-methyl-8-azabicyclo[3.2.1]octan-3-yl ester; belladonnine; Atropine Impurity 1（Atropine Impurity A）; ATROPAMINE; Benzeneacetic acid, α-methylene-, (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester; Tropine,atropate (ester); Apoatropine; Atropamine; Benzeneacetic acid, alpha-methylene-, 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, endo

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 389.1±42.0 °C at 760 mmHg
• 分子式: C₁₇H₂₁NO₂
• 分子量: 271.354
• 闪点: 136.5±18.8 °C
• 精确质量: 271.157227
• PSA: 29.54000
• LogP: 3.22
• 蒸汽压: 0.0±0.9 mmHg at 25°C
• 折射率: 1.572
• 储存条件: 库房通风低温干燥,与食品原料分开存放

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : YM4025000 CHEMICAL NAME : 1-alpha-H,5-alpha-H-Tropan-3-alpha-ol, atropate (ester) CAS REGISTRY NUMBER : 500-55-0 BEILSTEIN REFERENCE NO. : 0085429 LAST UPDATED : 199612 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C17-H21-N-O2 MOLECULAR WEIGHT : 271.39 WISWESSER LINE NOTATION : T56 A ANTJ A1 GOVYR&U1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 160 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,117,1989 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 10400 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB85-203644

安全

• 风险声明 (欧洲): 26/28
• 危险品运输编码: UN 1544
• 海关编码: 2933990090

合成路线

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海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%