1407-47-2

1407-47-2结构式
1407-47-2结构式

化源商城直购

中文名 血管紧张素
英文名 Angiotensin
中文别名 增血压素
英文别名 ANGIOTENSINII,HYPERTENSIN
angiotensin I
Hypertensin
密度 1.48g/cm3
分子式 C62H89N17O14
分子量 1296.48000
精确质量 1295.68000
PSA 493.22000
LogP 3.83280
折射率 1.679
储存条件 库房通风低温干燥,与食品原料分开存放
稳定性

本品为合成的八肽增血压素,是天然血管紧张肽Ⅱ的化学合成类似物,两者的差异在5位上,本品为缬氨酸,而天然的为异亮氨酸。为白色或类白色粉末,易溶于水,溶于甲醇、乙醇、丙二醇,不溶于乙醚、氯仿等。在干燥空气中稳定,在水溶液中逐渐分解为氨和α-L-血管紧张肽。
天然血管紧张肽Ⅱ在体内由人体血浆α2-球蛋白的血管紧张肽原酶经酶裂解后转化而成,具有强烈的血管收缩作用,能特异地引起血压上升。较去甲肾上腺素强40倍。本品活性是血管紧张肽Ⅱ的两倍。

CHEMICAL IDENTIFICATION

RTECS NUMBER :
BW2275000
CHEMICAL NAME :
Angiotonin
CAS REGISTRY NUMBER :
1407-47-2
LAST UPDATED :
199012

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
8 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973 Volume(issue)/page/year: -,43,1973 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
10 mg/kg
SEX/DURATION :
female 7-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 58,406,1969
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
20 ug/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - body wall
REFERENCE :
LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974- Volume(issue)/page/year: 8,525,1969
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
20 ug/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - homeostasis Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
REFERENCE :
LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974- Volume(issue)/page/year: 8,525,1969
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
200 ug/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974- Volume(issue)/page/year: 8,525,1969