187949-02-6

• 常用中文名：阿巴康唑
• 常用英文名：Albaconazole
• CAS号：187949-02-6
• 分子式：C₂₀H₁₆ClF₂N₅O₂
• 分子量：431.823
• 发布时间：2018-06-19 11:45:03
• 更新时间：2024-01-07 22:37:51
• Albaconazole, also known as UR-9825; W-0027, is a 14alpha-Demethylase inhibitor potentially for the treatment of fungal infection.

名称

• 中文名: 阿巴康唑
• 英文名: 7-chloro-3-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1,2,4-triazol-1-yl)butan-2-yl]quinazolin-4-one
• 中文别名: 7-氯-3-[(2R,3R)-3-(2,4-二氟苯基)-3-羟基-4-(1,2,4-三唑-1-基)丁-2-基]喹唑啉-4-酮
• 英文别名: albacolazole; 7-Chloro-3-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)-2-butanyl]-4(3H)-quinazolinone; (1R,2R)-7-chloro-3-[2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]quinazolin-4(3H)-one; UNII-YDW24Y8IAB; Albaconazole; UR 9825; Albaconazole [INN]; (1R,2R)-7-chloro-3-[2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]quinazilin-4(3H)-one; Albaconazol; 4(3H)-Quinazolinone, 7-chloro-3-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-; 7-chloro-3-((1r,2r)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1h-1,2,4-triazol-1-yl)propyl)quinazolin-4(3h)-one

物化性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 658.9±65.0 °C at 760 mmHg
• 熔点: 124-126°C
• 分子式: C₂₀H₁₆ClF₂N₅O₂
• 分子量: 431.823
• 闪点: 352.3±34.3 °C
• 精确质量: 431.096069
• PSA: 85.83000
• LogP: 3.00
• 蒸汽压: 0.0±2.1 mmHg at 25°C
• 折射率: 1.667
• 储存条件: -20°C Freezer

合成路线

122-51-0 206350-07-4 ~% 187949-02-6

文献：Journal of Medicinal Chemistry, , vol. 41, # 11 p. 1869 - 1882

127000-91-3 ~% 187949-02-6

文献：Journal of Medicinal Chemistry, , vol. 41, # 11 p. 1869 - 1882

89-77-0 ~% 187949-02-6

文献：Journal of Medicinal Chemistry, , vol. 41, # 11 p. 1869 - 1882

上下游产品

上游产品  3
122-51-0 206350-07-4 89-77-0
下游产品  0