7720-78-7

• 常用中文名：硫酸亚铁
• 常用英文名：Ferrous sulfate
• CAS号：7720-78-7
• 分子式：FeO₄S
• 分子量：151.908
• 相关类别： 原料药 血液系统用药 抗贫血药
• 发布时间：2018-02-06 08:00:00
• 更新时间：2024-01-02 13:47:30

• 1.用作饲料添加剂。饲料级硫酸亚铁是一种矿物质饲料添加剂，有饲料加工中作为铁的补充剂，同时对饲料中棉籽饼中所含的毒素具有脱毒作用。在农业中用作化肥、农药及除草剂，主治小麦的黑穗病等。医药中用作局部收敛剂及补血剂等。此外还用于制造铁盐、黑水、氧化铁红和靛青等，并用作媒染剂，净水剂、消毒剂及木材防腐剂等。也可用于照 相摄影。

  2.营养增补剂(铁质强化剂)；果蔬发色剂。如与烧明矾共用于茄子的腌制品能与其色素形成稳定的络盐，防止因有机酸引起的变色。但须注意，如铁用量多则变成黑墨色，明矾用量多则腌茄子的肉质过分坚实。配方例：长茄子300kg，食盐40kg，硫酸亚铁100g，烧明矾500g。尚能用作黑豆、糖煮蚕豆、海带等的发色剂。含丹宁多的食品，为避免造成黑变，不宜使用。亦可用于杀菌，脱臭，但杀菌力极弱。
  豆类中所含的隐色基色素在还原状态下无色，碱性下氧化则成黑色，利用硫酸亚铁的还原性，可达到护色目的，用量0.02%～0.03%。

• 【用途一】
  用于制铁盐、氧化铁颜料、媒染剂、净水剂、防腐剂、消毒剂等，医药上作抗贫血药
  【用途二】
  营养增补剂(铁质强化剂)；果蔬发色剂。如与烧明矾共用于茄子的腌制品能与其色素形成稳定的络盐，防止因有机酸引起的变色。但须注意，如铁用量多则变成黑墨色，明矾用量多则腌茄子的肉质过分坚实。配方例：长茄子300kg，食盐40kg，硫酸亚铁100g，烧明矾500g。尚能用作黑豆、糖煮蚕豆、海带等的发色剂。含丹宁多的食品，为避免造成黑变，不宜使用。亦可用于杀菌，脱臭，但杀菌力极弱。豆类中所含的隐色基色素在还原状态下无色，碱性下氧化则成黑色，利用硫酸亚铁的还原性，可达到护色目的，用量0.02%～0.03%。

名称

• 中文名: 硫酸亚铁
• 英文名: iron(2+) sulfate (anhydrous)
• 中文别名: 无水硫酸亚铁
• 英文别名: sulphuric acid, iron salt; iron(II) sulfate; EINECS 231-753-5; Iron(II) sulfate (1:1); Sulfuric acid, iron(2+) salt (1:1); Sulfuric acid iron (2+) salt (1:1); Sulfuric acid, iron (2+) salt (1:1); Iron monosulfate; iron(ii) sulphate; sulfuric acid iron(2+) salt (1:1); Ferrous sulphate; Iron sulphate; Sulfuric acid iron salt (1:1); MFCD00011014; Iron (II) sulfate (1:1); ferrous sulfate; Iron (2+) sulfate (1:1); Sulfuric acid, iron salt; Sulfuric acid, iron(2+), salt (1:1); Ferrous sulfate (1:1); Iron(2+) sulfate

物化性质

• 密度: 1.898
• 沸点: 330ºC at 760 mmHg
• 熔点: 64ºC
• 分子式: FeO₄S
• 分子量: 151.908
• 精确质量: 151.886673
• PSA: 82.98000
• LogP: 0.42550
• 外观性状: 淡绿色固体
• 储存条件:

  库房低温, 通风, 干燥; 与食品原料分开存放

• 稳定性:

  在90ºC失去六分子结晶水，在300ºC失去全部结晶水，在空气中渐渐风化，并氧化而成黄褐色。无水物与水作用又重新变为蓝绿色。有腐蚀性.在干燥空气中吸潮。可溶于水。在加热温度高于450℃时会发生明显分解，无论是在隔绝空气的条件下还是直接在空气中加热，硫酸亚铁分解所得到的最终固体产物都是Fe2O3。

• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:0

  3.氢键受体数量:4

  4.可旋转化学键数量:0

  5.互变异构体数量:无

  6.拓扑分子极性表面积88.6

  7.重原子数量:6

  8.表面电荷:0

  9.复杂度:62.2

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:2

• 更多:

  一、物性数据

  1. 性状：蓝色单斜晶体。

  2. 密度(g/mL,25/4℃）：3.4

  3. 相对蒸汽密度（g/mL,空气=1）：

  4. 熔点（ºC）：64

  5. 沸点（ºC,常压）：

  6. 沸点（ºC,5.2kPa）：

  7. 折射率：

  8. 闪点（ºC）：

  9. 比旋光度（º）：

  10. 自燃点或引燃温度（ºC）：

  11. 蒸气压（kPa,25ºC）：

  12. 饱和蒸气压（kPa,60ºC）：

  13. 燃烧热（KJ/mol）：

  14. 临界温度（ºC）：

  15. 临界压力（KPa）：

  16. 油水（辛醇/水）分配系数的对数值：

  17. 爆炸上限（%,V/V）：

  18. 爆炸下限（%,V/V）：

  19. 溶解性： 溶于水和甘油，几乎不溶于乙醇。

MSDS

Name: Iron(II) sulfate Material Safety Data Sheet Synonym: Iron monosulfate; Iron protosulfate; Sulferrous; Ferrous sulfate CAS: 7720-78-7 Section 1 - Chemical Product MSDS Name:Iron(II) sulfate Material Safety Data Sheet Synonym:Iron monosulfate; Iron protosulfate; Sulferrous; Ferrous sulfate Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 7720-78-7 Ferrous sulfate 100 231-753-5 Hazard Symbols: XN Risk Phrases: 22 36/37/38 Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Harmful if swallowed. Irritating to eyes, respiratory system and skin.Air sensitive.Moisture sensitive. Potential Health Effects Eye: May cause mild eye irritation. Skin: May cause skin irritation. Ingestion: Ingestion of large amounts may cause gastrointestinal irritation. May be harmful if swallowed. Ingestion may result in irritation of the esophagus, bleeding of the stomach and ulcer formation. Inhalation: May cause respiratory tract irritation. Chronic: Repeated exposure may increase iron levels in the liver, spleen and lymphatic system. Damage may occur in the spleen and liver. Section 4 - FIRST AID MEASURES Eyes: In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical aid. Skin: In case of contact, flush skin with plenty of water. Remove contaminated clothing and shoes. Get medical aid if irritation develops and persists. Wash clothing before reuse. Ingestion: If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid. Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Treat symptomatically and supportively. Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Substance is noncombustible. Extinguishing Media: Substance is noncombustible; use agent most appropriate to extinguish surrounding fire. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions. Provide ventilation. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Avoid breathing dust. Storage: Do not store in direct sunlight. Store in a cool, dry area away from incompatible substances. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Use process enclosure, local exhaust ventilation, or other engineering controls to control airborne levels below recommended exposure limits. Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Exposure Limits CAS# 7720-78-7: Belgium - TWA: (listed as iron salts (soluble)): 1 mg/m3 VLE (as Malaysia: (listed as iron salts (soluble)): 1 mg/m3 TWA (as Fe) Netherlands: (listed as iron salts (soluble)): 1 mg/m3 MAC (as Fe Spain: (listed as iron salts (soluble)): 1 mg/m3 VLA-ED (as Fe) Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Solid Color: blue-green Odor: None reported. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 64 deg C Autoignition Temperature: Not applicable. Flash Point: Not applicable. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Not available. Solubility in water: Soluble in water. Specific Gravity/Density: Not available. Molecular Formula: FeSO4 Molecular Weight: 151.9046 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable at room temperature in closed containers under normal storage and handling conditions. FeSO4.7H2O oxidizes in moist air forming a brown coating of basic ferric sulfate. Aqueous solutions are oxidized slowly by air when cold, rapidly when hot; rate of oxidation increased by addition of base or exposure to light. Conditions to Avoid: Light, dust generation, moisture, excess heat, prolonged exposure to air. Incompatibilities with Other Materials: Strong oxidizing agents, bases, lead acetate, silver salts, lime water, carbonates, potassium tartrate, gold salts, potassium iodide, sodium borate, sodium tartrate, tannin. Hazardous Decomposition Products: Oxides of sulfur, oxides of iron. Hazardous Polymerization: Has not been reported. Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 7720-78-7: NO8500000 LD50/LC50: CAS# 7720-78-7: Oral, mouse: LD50 = 680 mg/kg; Oral, rat: LD50 = 319 mg/kg; Oral, rat: LD50 = 533 mg/kg. For Iron(II) sulfate (1:1), heptahydrate (CAS = 7782-63-0): LDLo: 1389 mg/kg anhydrous (CAS = 7720-78-7): lowering not characterized in autonomic section, jaundice. Carcinogenicity: Ferrous sulfate - Not listed by ACGIH, IARC, or NTP. Other: See actual entry in RTECS for complete information. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Products which are considered hazardous for supply are classified as Special Waste and the disposal of such chemicals is covered by regulations which may vary according to location. Contact a specialist disposal company or the local waste regulator for advice. Empty containers must be decontaminated before returning for recycling. Section 14 - TRANSPORT INFORMATION IATA Shipping Name: Not regulated. Hazard Class: UN Number: Packing Group: IMO Shipping Name: Not regulated. Hazard Class: UN Number: Packing Group: RID/ADR Shipping Name: Not regulated. Hazard Class: UN Number: Packing group: USA RQ: CAS# 7720-78-7: 1000 lb final RQ; 454 kg final RQ Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: XN Risk Phrases: R 22 Harmful if swallowed. R 36/37/38 Irritating to eyes, respiratory system and skin. Safety Phrases: S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36 Wear suitable protective clothing. WGK (Water Danger/Protection) CAS# 7720-78-7: 1 Canada CAS# 7720-78-7 is listed on Canada's DSL List. CAS# 7720-78-7 is listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 7720-78-7 is listed on the TSCA inventory. SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

毒理学数据: 口服- 大鼠 LD50 319 毫克/ 公斤; 口服- 小鼠 LD50: 680 毫克/公斤 CHEMICAL IDENTIFICATION RTECS NUMBER : NO8500000 CAS REGISTRY NUMBER : 7720-78-7 LAST UPDATED : 199712 DATA ITEMS CITED : 47 MOLECULAR FORMULA : O4-S.Fe MOLECULAR WEIGHT : 151.91 WISWESSER LINE NOTATION : FE S-O4 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - child DOSE/DURATION : 250 mg/kg TOXIC EFFECTS : Gastrointestinal - alteration in gastric secretion Gastrointestinal - peritonitis Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - child DOSE/DURATION : 750 mg/kg TOXIC EFFECTS : Cardiac - pulse rate Vascular - BP lowering not characterized in autonomic section Gastrointestinal - nausea or vomiting TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - child DOSE/DURATION : 390 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - anorexia (human) Nutritional and Gross Metabolic - body temperature increase TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 60 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Gastrointestinal - nausea or vomiting Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - infant DOSE/DURATION : 4400 ug/kg TOXIC EFFECTS : Behavioral - coma Gastrointestinal - nausea or vomiting Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 10560 ug/kg TOXIC EFFECTS : Gastrointestinal - ulceration or bleeding from stomach TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - child DOSE/DURATION : 20 mg/kg TOXIC EFFECTS : Brain and Coverings - recordings from specific areas of CNS Behavioral - somnolence (general depressed activity) Behavioral - coma TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - child DOSE/DURATION : 150 mg/kg TOXIC EFFECTS : Behavioral - coma Gastrointestinal - hypermotility, diarrhea Gastrointestinal - nausea or vomiting TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 600 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - aggression Gastrointestinal - nausea or vomiting TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Human - man DOSE/DURATION : 441 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 319 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 155 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 680 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 106 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 60300 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 112 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 79 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraduodenal SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Cardiac - cardiac output Vascular - regional or general arteriolar constriction Nutritional and Gross Metabolic - metabolic acidosis TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 1200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 200 ug/m3/24H/65D-C TOXIC EFFECTS : Brain and Coverings - other degenerative changes Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1600 mg/kg/16W-I TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 7200 mg/kg SEX/DURATION : female 9-14 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetal death TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intratesticular DOSE : 12153 ug/kg SEX/DURATION : male 1 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - testes, epididymis, sperm duct MUTATION DATA TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Rodent - hamster Ovary DOSE/DURATION : 5 mmol/L REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 41,1628,1981 *** REVIEWS *** ACGIH TLV-TWA 1 mg(Fe)/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW. Volume(issue)/page/year: 4,615,1971 TOXICOLOGY REVIEW AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946- Volume(issue)/page/year: 38,409,1965 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 1 mg(Fe)/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,138,1971 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-DENMARK:TWA 1 mg(Fe)/m3 JAN 1993 OEL-FINLAND:TWA 1 mg(Fe)/m3 JAN 1993 OEL-THE NETHERLANDS:TWA 1 mg(Fe)/m3 JAN 1993 OEL-SWITZERLAND:TWA 1 mg(Fe)/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 1 mg(Fe)/m3;STEL 2 mg(Fe)/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 33230 No. of Facilities: 2551 (estimated) No. of Industries: 29 No. of Occupations: 35 No. of Employees: 31767 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 33230 No. of Facilities: 4071 (estimated) No. of Industries: 43 No. of Occupations: 57 No. of Employees: 85779 (estimated) No. of Female Employees: 19101 (estimated)

安全

• 风险声明 (欧洲): R25
• 安全声明 (欧洲): S45
• 海关编码: 2833291000

制备

1.硫酸与铁屑反应，反应生成的微酸性硫酸亚铁溶液经澄清去除杂质，再经冷却结晶、脱水、制得硫酸亚铁。或者将钛铁矿制造钛白粉生产中的副产物硫酸亚铁经重结晶精制，制得硫酸亚铁。

2.在强氢气流中，将七水硫酸亚铁先在70℃下，然后在150～200℃下加热，最后在250℃下加热，使其完全脱水即可制得无水硫酸亚铁。

海关

海关编码	2833291000