5411-22-3

• 常用中文名：盐酸苄非他明
• 常用英文名：Benzphetamine Hydrochloride
• CAS号：5411-22-3
• 分子式：C₁₇H₂₂ClN
• 分子量：275.81600
• 相关类别： 原料药 神经系统用药 其它神经系统用药
• 发布时间：2018-09-27 22:15:45
• 更新时间：2024-01-10 07:44:42
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名称

• 中文名: 盐酸苄非他明
• 英文名: benzphetamine hydrochloride
• 英文别名: Benzphetamine hydrchloride; Benzphetaminhydrochlorid; didrex; Benzyl-methyl-((S)-1-methyl-2-phenyl-aethyl)-amin,Hydrochlorid; (+)-Benzphetamine hydrochloride; (2S)-N-benzyl-N-methyl-1-phenylpropan-2-amine hydrochloride; benzyl-methyl-((S)-1-methyl-2-phenyl-ethyl)-amine,hydrochloride; d-benzphetaminehydrochloride; Benzphetamine Hydrochloride CIII (200 mg); BENZPHETAMINE HYDROCHLORIDE--DEA; inapetyl; (S)-BenzphetaMine Hydrochloride

物化性质

• 沸点: 334.3ºC at 760mmHg
• 熔点: 129-130°
• 分子式: C₁₇H₂₂ClN
• 分子量: 275.81600
• 闪点: 141.5ºC
• 精确质量: 275.14400
• PSA: 3.24000
• LogP: 4.55160
• 储存条件: 2-8°C

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : SG9625000 CHEMICAL NAME : Phenethylamine, N-benzyl-N,alpha-dimethyl-, hydrochloride, (+)- CAS REGISTRY NUMBER : 5411-22-3 LAST UPDATED : 199706 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C17-H21-N.Cl-H MOLECULAR WEIGHT : 275.85 WISWESSER LINE NOTATION : R1Y1&N1&1R &GH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 160 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CTCEA9 Current Therapeutic Research, Clinical & Experimental. (Therapeutic Research Press, Inc., POB 514, Tenafly, NJ 07670) V.1- 1959- Volume(issue)/page/year: 2,33,1960 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 227 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CTCEA9 Current Therapeutic Research, Clinical & Experimental. (Therapeutic Research Press, Inc., POB 514, Tenafly, NJ 07670) V.1- 1959- Volume(issue)/page/year: 2,33,1960 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 102 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 6,15,1964

安全

• 符号: GHS06, GHS08
• 信号词: Danger
• 危害声明: H301-H311-H331-H361
• 警示性声明: P261-P280-P301 + P310-P311
• 个人防护装备: Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
• 危害码 (欧洲): T,F
• 风险声明 (欧洲): 23/24/25-63-39/23/24/25-11
• 安全声明 (欧洲): 22-36/37/39-45-36/37-16
• 危险品运输编码: UN 2811 6.1/PG 3
• WGK德国: 3
• RTECS号: SG9625000
• 海关编码: 2921499090

合成路线

156-08-1 ~99% 5411-22-3

文献：Emcure Pharmaceuticals Limited Patent: US2011/46416 A1, 2011 ; Location in patent: Page/Page column 3 ;

100-44-7 51-57-0 ~91% 5411-22-3

文献：Pramanik, Chinmoy; Bapat, Kiran; Chaudhari, Ashok; Kulkarni, Mukund G.; Kolla, Rangarao; Sompalli, Srinivasarao; Tripathy, Narendra K.; Gurjar, Mukund K. Organic Process Research and Development, 2014 , vol. 18, # 4 p. 495 - 500

537-46-2 100-44-7 ~97% 156-08-1 5411-22-3 详细

文献：MALLINCKRODT INC. Patent: WO2006/73547 A1, 2006 ; Location in patent: Page/Page column 7-8 ;

345-78-8 ~% 5411-22-3

文献：Pramanik, Chinmoy; Bapat, Kiran; Chaudhari, Ashok; Kulkarni, Mukund G.; Kolla, Rangarao; Sompalli, Srinivasarao; Tripathy, Narendra K.; Gurjar, Mukund K. Organic Process Research and Development, 2014 , vol. 18, # 4 p. 495 - 500

152614-95-4 ~% 5411-22-3

文献：Pramanik, Chinmoy; Bapat, Kiran; Chaudhari, Ashok; Kulkarni, Mukund G.; Kolla, Rangarao; Sompalli, Srinivasarao; Tripathy, Narendra K.; Gurjar, Mukund K. Organic Process Research and Development, 2014 , vol. 18, # 4 p. 495 - 500

上下游产品

上游产品  5
156-08-1 100-44-7 51-57-0 537-46-2
345-78-8
下游产品  0

海关

海关编码	2921499090
中文概述	2921499090 其他芳香单胺及衍生物及它们的盐. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%