CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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YU2640000
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CHEMICAL NAME :
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Urea, 1,1'-tetramethylenebis(3-(2-chloroethyl)-3-nitroso-
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CAS REGISTRY NUMBER :
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60784-43-2
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LAST UPDATED :
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199612
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DATA ITEMS CITED :
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6
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MOLECULAR FORMULA :
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C10-H18-Cl2-N6-O4
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MOLECULAR WEIGHT :
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357.24
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WISWESSER LINE NOTATION :
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ONN2GVM4MVNNO&2G
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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46 mg/kg
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TOXIC EFFECTS :
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Lungs, Thorax, or Respiration - acute pulmonary edema Liver - hepatitis (hepatocellular necrosis), diffuse Blood - changes in bone marrow (not otherwise specified)
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Unreported
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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>1 gm/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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Sex chromosome loss and nondisjunction
MUTATION DATA
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TYPE OF TEST :
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Gene conversion and mitotic recombination
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TEST SYSTEM :
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Yeast - Saccharomyces cerevisiae
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DOSE/DURATION :
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500 umol/L/16H
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REFERENCE :
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MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 42,45,1977
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