104746-04-5

• 常用中文名：艾司利卡西平
• 常用英文名：Eslicarbazepine
• CAS号：104746-04-5
• 分子式：C₁₅H₁₄N₂O₂
• 分子量：254.284
• 相关类别： 研究领域 神经疾病
• 发布时间：2018-06-19 00:24:06
• 更新时间：2026-07-01 11:24:54
• Eslicarbazepine 是一种口服抗惊厥药,可用于局部癫痫的辅助治疗。

名称

• 中文名: 艾司利卡西平
• 英文名: Eslicarbazepine
• 中文别名: 氘4-(S)-利卡巴嗪; 利卡西平杂质6; S-10-单羟基二氢卡马西平; 利卡西; S-利卡西平; (S)-10-羟基二氢-5H-二苯并[B,F]氮杂卓-5-甲酰胺; (S)-艾司利卡西平; (S)-10-羟基-10,11-二氢-5H-二苯并[[B,F]氮杂-5-甲酰胺; 艾司利卡西平,10 MM DMSO 溶液
• 英文别名: (S)-10-Hydroxy-10,11-dihydro-5H-dibenzo[b,f]azine-5-cboxaMide; high quality S-10-MONOHYDROXY-DIHYDRO-CBAMAZIN; (S)-10-Monohydroxy-10,11-dihydro CbaMazine (Eslicbazine); (S)-10-Monohydroxydihydrocbamazine; EC -9; (S)-Licbazine; T C676 BN&T&J BVZ IQ &&S Form; MHD; Eslicbazine, 10 mM in DMSO; (S)-10-Hydroxy-10,11-dihydro-5H-dibenzo[b,f]azin-5-cboxamide; Eslicbazine (BIA ); (10S)-10-Hydroxy-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide; (S)-10-Monohydroxy-dihydro-cbamazine (Eslicbazine); Eslicbazine D3Q: What is Eslicbazine D3 Q: What is the CAS Number of Eslicbazine D3; D4-(S)-Licbazine; 5H-Dibenz[b,f]azine-5-cboxamide, 10,11-dihydro-10-hydroxy-, (10S); (S)-Licarbazepine; (10S)-10-hydroxy-10,11-dihydro-5H-dibenzo[b,f]azine-5-cboxamide; S5VXA428R4; Licbazine S-Isomer; S-(+)-10,11-Dihydro-10-hydroxy-5H-dibenz[b,f]azine-5-cboxamide,S-MHD; (+)-Licarbazepine; (S)-(+)-10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide; (S)-(+)-licarbazepine; (10S)-10,11-DIHYDRO-10-HYDROXY CBAMAZINE; (S)-10-hydroxy-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide; 5-hydroxy-4a,5-dihydro-4H-dibenzo[b,f]azepine-10-carboxamide; Eslicbazine; Eslicbazine (Synonyms: BIA ); Licbazine Impurity 6; (S)-Licbazine-d4; Inhibitor,inhibit,Eslicbazine; S-licarbazepine; (S)-(+)-10,11-Dihydro-10-hydroxy-5H-dibenzo[b,f]azine-5-cboxamide; (S)-Licbazine-d4 (Eslicbazine-d4); (10S); Licbazine Impurity 2(Licbazine S-Isomer); Erelib; S-10-MONOHYDROXY-DIHYDRO-CBAMAZIN; Pazzul; Monohydroxy Cbamazine

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 431.3±55.0 °C at 760 mmHg
• 熔点: 188-190°C
• 分子式: C₁₅H₁₄N₂O₂
• 分子量: 254.284
• 闪点: 214.6±31.5 °C
• 精确质量: 254.105530
• PSA: 66.56000
• LogP: 0.93
• 外观性状: 灰白色固体
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.677
• 储存条件: 2-8℃

生物活性

• 描述: Eslicarbazepine 是一种口服抗惊厥药,可用于局部癫痫的辅助治疗。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 体内研究: Eslicarbazepine是一种抗癫痫药物,与卡马西平化学相关但具有更有利的安全性。 Eslicarbazepine acetate是eslicarbazepine(S-licarbazepine)的前药,它是β-分泌酶和电压门控钠通道的双重抑制剂[1] [2]。
• 参考文献:

  [1]. Finelli E, et al. Patch testing in a case of eslicarbazepine and carbamazepine induced cutaneous reaction. Eur Ann Allergy Clin Immunol. 2018 Sep;50(5):229-231.

  [2]. Sibhghatulla Shaikh, et al. Aptiom (Eslicarbazepine Acetate) as a Dual Inhibitor of β-Secretase and Voltage-Gated Sodium Channel: Advancement in Alzheimer's Disease-Epilepsy Linkage via an Enzoinformatics Study. CNS & Neurological Disorders Drug Targets Volume 13 , Issue 7 , 2014.

安全

• 海关编码: 2933990090

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海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%