艾司利卡西平

• 常用名: 艾司利卡西平
• 英文名: Eslicarbazepine
• CAS号: 104746-04-5
• 分子量: 254.284
• 密度: 1.3±0.1 g/cm3
• 沸点: 431.3±55.0 °C at 760 mmHg
• 分子式: C₁₅H₁₄N₂O₂
• 熔点: 188-190°C
• 闪点: 214.6±31.5 °C

艾司利卡西平用途

Eslicarbazepine 是一种口服抗惊厥药,可用于局部癫痫的辅助治疗。

艾司利卡西平名称

• 中文名: 艾司利卡西平
• 英文名: Eslicarbazepine

艾司利卡西平生物活性

• 描述: Eslicarbazepine 是一种口服抗惊厥药,可用于局部癫痫的辅助治疗。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 体内研究: Eslicarbazepine是一种抗癫痫药物,与卡马西平化学相关但具有更有利的安全性。 Eslicarbazepine acetate是eslicarbazepine(S-licarbazepine)的前药,它是β-分泌酶和电压门控钠通道的双重抑制剂[1] [2]。
• 参考文献:

  [1]. Finelli E, et al. Patch testing in a case of eslicarbazepine and carbamazepine induced cutaneous reaction. Eur Ann Allergy Clin Immunol. 2018 Sep;50(5):229-231.

  [2]. Sibhghatulla Shaikh, et al. Aptiom (Eslicarbazepine Acetate) as a Dual Inhibitor of β-Secretase and Voltage-Gated Sodium Channel: Advancement in Alzheimer's Disease-Epilepsy Linkage via an Enzoinformatics Study. CNS & Neurological Disorders Drug Targets Volume 13 , Issue 7 , 2014.

艾司利卡西平物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 431.3±55.0 °C at 760 mmHg
• 熔点: 188-190°C
• 分子式: C₁₅H₁₄N₂O₂
• 分子量: 254.284
• 闪点: 214.6±31.5 °C
• 精确质量: 254.105530
• PSA: 66.56000
• LogP: 0.93
• InChIKey: BMPDWHIDQYTSHX-AWEZNQCLSA-N
• SMILES: NC(=O)N1c2ccccc2CC(O)c2ccccc21
• 外观性状: 灰白色固体
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.677
• 储存条件: 2-8℃

艾司利卡西平安全信息

• 海关编码: 2933990090

艾司利卡西平海关

• 海关编码: 2933990090
• 中文概述: 2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
• Summary: 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

艾司利卡西平靶点实验

查看更多实验

实验名称：AUC (0 to 72 hrs) in human treated with monohydroxy derivative of OXC at 250 mg, iv a... 来源：ChEMBL 靶标：Homo sapiens External Id：CHEMBL3541449

实验名称：AUC (0 to 72 hrs) in human treated with monohydroxy derivative of OXC at 200 mg, iv a... 来源：ChEMBL 靶标：Homo sapiens External Id：CHEMBL3541132

实验名称：Drug excretion in human urine assessed as total amount of drug eliminated treated wit... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3541451

实验名称：Total plasma clearance in human treated with monohydroxy derivative of OXC at 200 mg,... 来源：ChEMBL 靶标：Homo sapiens External Id：CHEMBL3541457

实验名称：ASTRAZENECA: Octan-1-ol/water (pH7.4) distribution coefficent measured by a shake fl... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3301363

实验名称：Total plasma clearance in human treated with monohydroxy derivative of OXC at 150 mg,... 来源：ChEMBL 靶标：Homo sapiens External Id：CHEMBL3541455

实验名称：Total plasma clearance in human treated with monohydroxy derivative of OXC at 250 mg,... 来源：ChEMBL 靶标：Homo sapiens External Id：CHEMBL3541459

实验名称：Compound was tested intraperitoneally for anticonvulsant activity against MES-induced... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL779477

实验名称：Compound was tested intraperitoneally for anticonvulsant activity by rotarod test 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL788728

实验名称：AUC (0 to 72 hrs) in human treated with monohydroxy derivative of OXC at 150 mg, iv a... 来源：ChEMBL 靶标：Homo sapiens External Id：CHEMBL3541130

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艾司利卡西平英文别名

• (+)-Licarbazepine
• (S)-(+)-10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide
• (S)-(+)-licarbazepine
• T C676 BN&T&J BVZ IQ &&S Form
• MHD
• (S)-10-hydroxy-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide
• Eslicarbazepine
• 5-hydroxy-4a,5-dihydro-4H-dibenzo[b,f]azepine-10-carboxamide
• (10S)-10-Hydroxy-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide
• S-licarbazepine
• (S)-Licarbazepine
• S5VXA428R4