496775-61-2

• 常用中文名：伊屈泼帕
• 常用英文名：Eltrombopag
• CAS号：496775-61-2
• 分子式：C₂₅H₂₂N₄O₄
• 分子量：442.467
• 相关类别： 信号通路 免疫及炎症 血小板生成素受体
• 发布时间：2018-03-05 08:00:00
• 更新时间：2026-07-01 10:07:26
• Eltrombopag(SB-497115)是口服活性的促血小板生成素受体激动剂，能刺激血小板生成。

名称

• 中文名: 伊屈泼帕
• 英文名: eltrombopag
• 中文别名: 3-[3-[[2-(3,4-二甲基苯基)-5-甲基-3-羰基-1H-吡唑-4-基]二氮烯基]-2-羟基苯基]苯甲酸; 伊曲波帕; 艾曲波帕; 艾曲波帕 ELTROMBOPAG OLAMINE; 艾曲波帕 (EQ-5); 伊屈泼帕(艾曲波帕); 3'-[2-[(2Z)-1-(3,4-二甲基苯基)-1,5-二氢-3-甲基-5-氧代-4H-吡唑-4-亚基]肼基]-2'-羟基-[1,1'-联苯]-3-羧酸; 艾曲波帕相关杂质; 艾曲泼帕; 埃尔托姆波帕; (Z)-3'-(2-(1-(3,4-二甲基苯基)-3-甲基-5-氧代-1H-吡唑-4(5H)-亚基)肼基)-2'-羟基-[1,1'-联苯基]-3-羧酸; 艾曲波帕 Eltrombopag; 艾曲波帕,10 MM DMSO 溶液; 艾曲波帕及中间体; 伊屈泼帕杂质; 艾屈泼帕; 3'-[(2Z)-2-[1-(3,4-二甲基苯基)-1,5-二氢-3-甲基-5-氧代-4H-吡唑-4-亚苯基]肼基]-2'-羟基[1,1'-联苯]-3-羧酸; 埃尔托姆波帕杂质; 艾曲波帕(原料药); 伊屈泼帕(TPOR激动剂); 伊曲泼帕; 波帕; 艾曲波帕游离碱
• 英文别名: Unii-S56D65xj; Eltrombopag 3'-[2-[(2Z)-1-(3,4-Dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazinyl]-2'-hydroxy-[1,1'-biphenyl]-3-cboxylic acid; 3'-{(2Z)-2-[1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene] hydrazino}-2'-hydroxy-3-biphenylcboxylic acid; 3'-[2-[(2Z)-1-(3,4-Dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazinyl]-2'-hydroxy-[1,1'-biphenyl]-3-cboxylic acid Eltrombopag; (E)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxybiphenyl-3-cboxylic acid; Eltrombopag (10mM in DMSO); ltrombopag; (Z)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy; (Z)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-cboxylic acid; 3'-{(2E)-2-[1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene]hydrazino}-2'-hydroxy-3-biphenylcarboxylic acid; SB-497115-GR; Eltrombopag Acid; (Z)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydro; (E)-Eltrombopag; Eltrombopag 13C4Q: What is Eltrombopag 13C4 Q: What is the CAS Number of Eltrombopag 13C4 Q: What is the storage condition of Eltrombopag 13C4 Q: What e the applications of Eltrombopag 13C4; Eltrombopag free acid; Ikuppa; 3-(5-{2-[2-(3,4-diMethylphenyl)-5-Methyl-3-oxo-2,3-dihydro-1H-pyrazol-4-yl]hydrazin-1-ylidene}-6-oxocyclohexa-1,3-dien-1-yl)benzoic acid; [1,1'-Biphenyl]-3-cboxylic acid, 3'-[(2Z)-2-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazinyl]-2'-hydroxy; Sb497115; Eltrombopa; Eltrombopag Free Base; EltroMbopag (SB-497115; Promacta; (1,1'-Biphenyl)-3-cboxylic acid, 3'-((2Z)-(1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene)hydrazino)-2'-hydroxy; Sb-497115; Eltrombopag - Bio-X; Eltrombopag [inn]; [1,1'-Biphenyl]-3-cboxylic acid, 3'-[2-[(2Z)-1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazinyl]-2'-hydroxy; Eltrombopag (SB-497115); 3-[(5E)-5-[[2-(3,4-dimethylphenyl)-5-methyl-3-oxo-1H-pyrazol-4-yl]hydrazinylidene]-6-oxocyclohexa-1,3-dien-1-yl]benzoic acid; 3-[3-[[2-(3,4-dimethylphenyl)-5-methyl-3-oxo-1H-pyrazol-4-yl]diazenyl]-2-hydroxyphenyl]benzoic acid; 3'-[2-[(2Z)-1-(3,4-Dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazinyl]-2'-hydroxy-[1,1'-biphenyl]-3-cboxylic acid; (E)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydro

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 656.8±65.0 °C at 760 mmHg
• 熔点: 242-244ºC
• 分子式: C₂₅H₂₂N₄O₄
• 分子量: 442.467
• 闪点: 351.0±34.3 °C
• 精确质量: 442.164093
• PSA: 114.59000
• LogP: 3.70
• 外观性状: 橙色至红色固体
• 蒸汽压: 0.0±2.1 mmHg at 25°C
• 折射率: 1.667
• 储存条件: 室温，干燥

生物活性

• 描述: Eltrombopag是一种血小板生成素 (TPO) 受体激动剂,治疗导致血小板减少的某些病症。
• 相关类别:
  信号通路 >> 免疫及炎症 >> 血小板生成素受体
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Erickson-Miller CL, et al. Preclinical activity of eltrombopag (SB-497115), an oral, nonpeptide thrombopoietin receptor agonist. Stem Cells. 2009 Feb;27(2):424-30.

  [2]. Erickson-Miller CL, et al. Discovery and characterization of a selective, nonpeptidyl thrombopoietin receptor agonist. Exp Hematol. 2005 Jan;33(1):85-93.

  [3]. McHutchison JG, et al. Eltrombopag for thrombocytopenia in patients with cirrhosis associated with hepatitis C. N Engl J Med. 2007 Nov 29;357(22):2227-36.

  [4]. Jenkins JM, et al. Phase 1 clinical study of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist. Blood. 2007 Jun 1;109(11):4739-41.

  [5]. Saleh MN, et al. Safety and efficacy of eltrombopag for treatment of chronic immune thrombocytopenia: results of the long-term, open-label EXTEND study. Blood. 2013 Jan 17;121(3):537-45.

安全

• 海关编码: 2933990090

海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%