72351-59-8

72351-59-8结构式

常用中文名：1,4-二苄基哌嗪-2-羧酸乙酯
常用英文名：Ethyl 1,4-dibenzyl-2-piperazinecarboxylate
CAS号：72351-59-8
分子式：C₂₁H₂₆N₂O₂
分子量：338.443
发布时间：2018-10-13 19:39:22
更新时间：2024-01-11 18:33:09

中文名	1,4-二苄基哌嗪-2-羧酸乙酯
英文名	Ethyl 1,4-dibenzylpiperazine-2-carboxylate
中文别名	1,4-二苄基吡嗪-2-甲酸乙酯
英文别名	MFCD00126366 1,4-bis(phenylmethyl)-2-piperazinecarboxylic acid,ethyl ester Ethyl 1,4-dibenzyl-2-piperazinecarboxylate 1,4-dibenzyl-2-ethoxycarbonylpiperazine 1,4-dibenzylpiperazine-2-carboxylic acid ethyl ester 2-Piperazinecarboxylic acid, 1,4-bis(phenylmethyl)-, ethyl ester BUTTPARK 324-68 Ethyl 1,4-dibenzylpiperazine-2-carboxylate

密度	1.1±0.1 g/cm3
沸点	442.0±45.0 °C at 760 mmHg
分子式	C₂₁H₂₆N₂O₂
分子量	338.443
闪点	221.1±28.7 °C
精确质量	338.199432
PSA	32.78000
LogP	3.21
蒸汽压	0.0±1.1 mmHg at 25°C
折射率	1.579

Name:	Ethyl 1 4-dibenzylpiperazine-2-carboxylate 97% Material Safety Data Sheet
Synonym:	N,N'-1,4-Dibenzyl-2-ethoxycarbonyl piperazin
CAS:	72351-59-8

Section 1 - Chemical Product MSDS Name:Ethyl 1 4-dibenzylpiperazine-2-carboxylate 97% Material Safety Data Sheet
Synonym:N,N'-1,4-Dibenzyl-2-ethoxycarbonyl piperazin

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
72351-59-8	Ethyl 1,4-dibenzylpiperazine-2-carboxy	97%	unlisted

Hazard Symbols: XI
Risk Phrases: 36/37/38

Section 3 - HAZARDS IDENTIFICATION

EMERGENCY OVERVIEW
Irritating to eyes, respiratory system and skin.
Potential Health Effects
Eye:
Causes eye irritation.
Skin:
Causes skin irritation. May be harmful if absorbed through the skin.
Ingestion:
May cause irritation of the digestive tract. May be harmful if swallowed.
Inhalation:
Causes respiratory tract irritation. May be harmful if inhaled.
Chronic:
Not available.

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container.

Section 7 - HANDLING and STORAGE
Handling:
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 72351-59-8: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Viscous liquid
Color: orange
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: 204 - 208 deg C @1.5mmHg
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C21H26N2O2
Molecular Weight: 338.45

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Not available.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Strong oxidizing agents, bases.
Hazardous Decomposition Products:
Hydrogen cyanide, nitrogen oxides, carbon monoxide, carbon dioxide, ammonia.
Hazardous Polymerization: Has not been reported

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 72351-59-8 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
Ethyl 1,4-dibenzylpiperazine-2-carboxylate - Not listed by ACGIH, IARC, or NTP.

Section 12 - ECOLOGICAL INFORMATION

Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
No information available.
IMO
No information available.
RID/ADR
No information available.

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XI
Risk Phrases:
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 37/39 Wear suitable gloves and eye/face
protection.
WGK (Water Danger/Protection)
CAS# 72351-59-8: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 72351-59-8 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 72351-59-8 is not listed on the TSCA inventory.
It is for research and development use only.

SECTION 16 - ADDITIONAL INFORMATION
N/A

危害码 (欧洲)	Xi: Irritant;
风险声明 (欧洲)	R36/37/38
安全声明 (欧洲)	26-36/37/39-37/39
海关编码	2933599090

3674-13-3

140-28-3

~99%

72351-59-8

文献：Boehringer Ingelheim International GmbH Patent: US2004/192729 A1, 2004 ; Location in patent: Page 35 ;

14165-27-6

535-11-5

~96%

72351-59-8

文献：N.V. ORGANON Patent: WO2008/33764 A2, 2008 ; Location in patent: Page/Page column 53 ; WO 2008/033764 A2

644-33-7

3674-13-3

~64%

72351-59-8

文献：SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; REN, Qingyun; LIU, Xinchang; SIEGFRIED, Goldmann Patent: WO2014/29193 A1, 2014 ; Location in patent: Paragraph 00473 ;

14165-27-6

3674-13-3

~80%

72351-59-8

文献：NeuroMed Technologies, Inc. Patent: US2004/44004 A1, 2004 ;

上游产品 5
3674-13-3 140-28-3 14165-27-6 535-11-5
644-33-7
下游产品 10
2465-79-4 89941-07-1 134749-45-4 28795-50-8
70403-11-1 94437-04-4 54969-29-8 63285-62-1
646523-34-4 646523-38-8

海关编码	2933599090
中文概述	2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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