625115-52-8

• 常用中文名：Nelociguat
• 常用英文名：Nelociguat
• CAS号：625115-52-8
• 分子式：C₁₉H₁₇FN₈O₂
• 分子量：408.389
• 相关类别： 信号通路 G 蛋白偶联受体/G 蛋白 鸟苷酸环化酶
• 发布时间：2018-06-12 15:37:00
• 更新时间：2026-07-04 18:30:46
• Nelociguat (BAY60-4552)是一种一氧化氮敏感的可溶性的鸟苷酸环化酶激活物。

名称

• 中文名: N-[4,6-二氨基-2-[1-[(2-氟苯基)甲基]-1H-吡唑并[3,4-b]吡啶-3-基]-5-嘧啶]-氨基甲酸甲酯
• 英文名: methyl N-[4,6-diamino-2-[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl]carbamate
• 中文别名: 甲基[(4,6-二氨基-2-{1-[(2-氟苯基)甲基]吡唑并[3,4-B]吡啶-3-基}嘧啶-5-基)氨基]甲酸甲酯; 利奥西呱脱甲基杂质D; N-去甲利奥西呱; 2-[1-(2-氟苄基)吡唑并[3,4-b]吡啶-3-基]-4,6-二氨基-5-嘧啶基]氨基甲酸甲酯; N-[4,6-二氨基-2-[1-[(2-氟苯基)甲基]-1H-吡唑并[3,4-B]吡啶-3-基]-5; 利奥西呱杂质NK1; 13C,2H3]-N-去甲基-RIOCIGUAT; mmu-miR-6908-5p mimicmmu-miR-6908-5p 模拟物; 利奥西呱中间体V; N-[4,6-二氨基-2-[1-[(2-氟苯基)甲基]-1H-吡唑并[3,4-B]吡啶-3-基]-5-嘧啶]-氨基甲酸甲酯; 13C, 氘3-N-去甲基利奥西呱; 甲基(4,6-二氨基-2-(1-苄基-5-氟-1H-吡唑[3,4-B]吡啶-3-基)嘧啶-5-基)氨基甲酸酯; 利奥西呱杂质A; 4,6-二氨基-2-[1-(2-氟苄基)-1H-吡唑并[3,4-B]吡啶-3-基]-5-嘧啶氨基甲酸甲酯; 利托那韦中间体/ N-[N-甲基-N-((2-异丙基-4-噻唑基)甲基)氨基)羰基]-L-缬氨酸锂盐METHYL (4,6-DIAMINO-2-(1-(2-FLUOROBENZYL)-1H-PYRAZOLO[3,4-B]PYRIDIN-3-YL)PYRIMIDIN-5-YL)CBAMATE; 利奥西呱杂质4; 利奥西呱杂质04; N-去甲基利奥西呱; N-去甲基利奥西呱杂质5; 13C,氘6-利奥西格特; 维立西呱杂质VCG-C; 利奥西胍杂质08; 2-[1-(2-氟苄基)-1H-吡唑并[3,4-B]吡啶-3-基]-6-二甲氨基-7,9-二甲基-7H-嘌呤-8(9H)-酮; N-去甲基-瑞司瓜特; 利奥西呱杂质H
• 英文别名: methyl N-[4,6-diamino-2-[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl]cbamate; Carbamic acid,N-(4,6-diamino-2-(1-((2-fluorophenyl)methyl)-1H-pyrazolo(3,4-b)pyridin-3-yl)-5-pyrimidinyl)-,methyl ester; UNII-M2A18LL56O; N-Desmethyl Riociguat; inhibit,Inhibitor,Guanylate Cyclase,Nelociguat; Methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl}carbamate; Name: Methyl [4,6-diaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]cbaMate; Nelociguat [INN]; BAY 2; Desmethyl RiociguatQ: What is Desmethyl Riociguat Q: What is the CAS Number of Desmethyl Riociguat Q: What is the storage condition of Desmethyl Riociguat Q: What e the applications of Desmethyl Riociguat; 13C, D3-N-desmethyl-Riociguat; Riociguat Impurity A; Cbamic acid, N-[4,6-diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-, methyl ester; Riociguat N-Desmethyl Impurity; methyl [(4,6-diamino-2-{1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl}pyrimidin-5-yl)amino]methanoate; Riociguat-4; Desmethyl Riociguat; 13C,-Riociguat; methyl (4,6-diamino-2; Carbamic acid,(4,6-diamino-2-(1-((2-fluorophenyl)methyl)-1H-pyrazolo(3,4-b)pyridin-3-yl)-5-pyrimidinyl)-,methyl ester; Cbamic acid,[4,6-diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-, methyl ester; Methyl [4,6-diaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]cbaMate; Nelociguat, 10 mM in DMSO; N-Desmethyl Riociguat/Methyl(4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)cbamate; Riociguat Impurity A (N-Desmethyl Riociguat); Riociguat Impurity 4; Methyl [4,6-Diamino-2-[1-(2-fluorobenzyl)pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]cbamate; Riociguat Impurity 19/N-Desmethyl Riociguat/Methyl(4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)cbamate; Riociguat Impurity NK1; Bay 60-4552; Riociguat ImpurityK1; Carbamic acid, N-[4,6-diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-, methyl ester

物化性质

• 密度: 1.6±0.1 g/cm3
• 沸点: 533.3±50.0 °C at 760 mmHg
• 分子式: C₁₉H₁₇FN₈O₂
• 分子量: 408.389
• 闪点: 276.3±30.1 °C
• 精确质量: 408.145844
• PSA: 151.08000
• LogP: -0.10
• 蒸汽压: 0.0±1.4 mmHg at 25°C
• 折射率: 1.748
• 储存条件: 2-8℃

生物活性

• 描述: Nelociguat (BAY60-4552)是一种一氧化氮敏感的可溶性的鸟苷酸环化酶激活物。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 鸟苷酸环化酶
  研究领域 >> 心血管疾病
• 体外研究: 可溶性鸟苷酸环化酶(sGC)是一氧化氮(NO)信号通路中的关键酶[1]。 Riociguat不仅通过细胞色素P450同工酶3A4(CYP3A4),CYP2C8和CYP2J2代谢到BAY60-4552,还通过位于肝脏和肺部的CYP1A1代谢[2]。
• 体内研究: GSK2181236A和BAY 60-4552提供针对高血压诱导的终末器官损伤的部分益处。在自发性高血压性卒中易感大鼠中,低剂量的BAY 60-4552可降低尿量并提高生存率。高剂量还可以减少尿量,另外还可以减少微量白蛋白尿并减少平均动脉压的增加。 0.3和3mg/kg /天剂量的BAY 60-4552均提高了46％和69％的存活率。用BAY 60-4552(0.3和3.0 mg/kg /天)治疗7周,剂量依赖性地将尿量减少到79±11和56±10 mL /天[1]。 BAY 60-4552和伐地那非提供协同有益作用,因此可以挽救根治性前列腺切除术后经历PDE5抑制剂治疗失败的患者[3]。
• 动物实验: 大鼠：用载体（0.5％HPMC，5％DMSO和0.1％吐温80; 10mL / kg; n = 14），GSK2181236A（0.1或1.0mg / kg; n = 11-14）口服强饲大鼠，或BUE 60-4552（0.3或3.0mg / kg; n = 10-12）在缺血前2小时。在缺血开始时和再灌注24小时后收集血液。获得血浆用于分析[1]。
• 参考文献:

  [1]. Costell MH, et al. Comparison of soluble guanylate cyclase stimulators and activators in models of cardiovascular disease associated with oxidative stress. Front Pharmacol. 2012 Jul 5;3:128.

  [2]. Zhao X, et al. Pharmacokinetics of the Soluble Guanylate Cyclase Stimulator Riociguat in Healthy Young Chinese Male Non-Smokers and Smokers: Results of a Randomized, Double-Blind, Placebo-Controlled Study. Clin Pharmacokinet. 2016 May;55(5):615-24.

  [3]. Oudot A, et al. Combination of BAY 60-4552 and vardenafil exerts proerectile facilitator effects in rats with cavernous nerve injury: a proof of concept study for the treatment of phosphodiesterase type 5 inhibitor failure. Eur Urol. 2011 Nov;60(5):1020-6.

安全

• 海关编码: 2933990090

海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%