123853-39-4

• 常用中文名：4-(2,3-二氯苯基)-5-(甲氧基羰基)-2,6-二甲基-1,4-二氢吡啶-3-羧酸
• 常用英文名：UNII:446669RI9H
• CAS号：123853-39-4
• 分子式：C₁₆H₁₅Cl₂NO₄
• 分子量：356.201
• 相关类别： 原料药 循环系统用药 抗高血压病药
• 发布时间：2018-11-23 19:17:46
• 更新时间：2026-07-04 22:06:16

名称

• 中文名: 4-(2,3-二氯苯基)-1,4-二氢-2,6-二甲基-3,5-吡啶二羧酸 3-甲酯
• 英文名: 4-(2,3-Dichlorophenyl)-5-(methoxycarbonyl)-2,6-dimethyl-1,4-dihyd ro-3-pyridinecarboxylic acid
• 中文别名: 氯维地平杂质1-13C-D3; 去甲苯醚非洛地平; 氯维地平中间体; 单甲基非洛地平; 丁酸氯维地平杂质; 1,4-二氢-2,6-二甲基-4-(2',3'-二氯苯基)-5-羧甲基-3-吡啶甲酸; 氯维地平酸杂质; O-去乙基非洛地平; 4-(2,3-二氯苯基)-1,4-二氢-2,6-二甲基-3,5-吡啶二羧酸3-甲酯; 4-(2,3-二氯苯基)-1,4-二氢-2,6-二甲基-3,5-吡啶二甲酸单甲酯; 丁酸氯维地平水解物; 2,6-二甲基-4-(2,3-二氯苯基)-5-(甲氧羰基)-1,4-二氢吡啶-3-甲酸; 杂质1
• 英文别名: Cleviprex Impurity 1; 1,4-dihydro-2,6-dimethyl-4-(2,3-dichlorophenyl)-pyridine-3,5-dicarboxylic acid monomethyl ester; Desethyl Felodipine //BP; 1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-cboxy methyl-3-pyridinecboxylic acid; 4-(2,3-Dichlorophenyl); Clevidipine Butyrate Impurity1474; 3-methoxycarbonyl-2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-5-carboxylic acid; 2,6-dimethyl-1,4-dihydropyridine-3-cboxylic acid; dimethyl 1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate; Desethyl Felodipine; 4-(2,3-dichlorophenyl)-5-(methoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylic acid; 1,4-dihydro-2,6-dimethyl-5-methoxycarbonyl-4-(2,3-dichlorophenyl)pyridine-3-carboxylic acid; 1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-cboxymethylpyridin-3-cboxylic acid; 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicboxylic acid 3-methyl ester; Felodipine Impurity D; 1,4-Dihydro-2,6-dimethyl-3-methoxycarbonyl-4-(3-nitrophenyl)-pyridine-5-carboxylic acid; methyl Hantzsch ester; 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 5-methyl ester; 1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-carboxy methyl-3-pyridinecarboxylic acid; 1,4-Dihydro-2,6-diMethyl-4-(2',3'-dichlorophenyl)-5-cboxy Meth; levidipine Impurity C-d3; Monomethyl Felodipine; 1,4-dihydro-2,6-dimethyl-5-methoxy-carbonyl-4-(3-nitrophenyl)pyridine-3-carboxylic acid; 3,5-Pyridinedicboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-diMethyl-, 3-Methyl ester; 2,6-dimethyl-3-carbomethoxy-4-(2,3-dichlorophenyl)-5-carboxy-1,4-dihydropyridine; 2,6-dimethyl-3,5-dimethoxycarbonyl-1,4-dihydropyridine; 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid dimethyl ester; (+)-4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-5-methoxycarbonyl-3-pyridinecarboxylic acid; 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-methyl ester; 4-(2,3-Dichlorophenyl)-5-(methoxycbonyl)-2,6-dimethyl-1,4-dihyd ro-3-pyridinecboxylic acid; clevidipine acid; 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, monomethyl ester; 5-methoxycarbonyl-4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylic acid; 1,4-dihydro-3-methoxycarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-5-pyridinecarboxylic acid; 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicboxylic acid monomethyl ester; Intermediate of Clevidipine; 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid dimethyl ester; 1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-cboxy methyl-3-pyridinecboxylic acid //BP; 4-(2,3-Dichlorophenyl)-5-(methoxycarbonyl)-2,6-dimethyl-1,4-dihydro-3-pyridinecarboxylic acid; 1,4-dihydro-2,6-dimethyl-4-(2',3'-dichorophenyl)-5-methoxycarbonyl-3-pyridinecarboxylic acid

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 483.0±45.0 °C at 760 mmHg
• 分子式: C₁₆H₁₅Cl₂NO₄
• 分子量: 356.201
• 闪点: 245.9±28.7 °C
• 精确质量: 355.037811
• PSA: 75.63000
• LogP: 3.15
• 蒸汽压: 0.0±1.3 mmHg at 25°C
• 折射率: 1.581
• 储存条件: 室温，干燥

安全

• 危害码 (欧洲): Xi

合成路线

6334-18-5 ~% 123853-39-4

文献：Ogawa; Nakato; Tsuchida; Hatayama Chemical and Pharmaceutical Bulletin, 1993 , vol. 41, # 1 p. 108 - 116

105-45-3 ~% 123853-39-4

文献：Ogawa; Nakato; Tsuchida; Hatayama Chemical and Pharmaceutical Bulletin, 1993 , vol. 41, # 1 p. 108 - 116

74073-22-6 ~% 123853-39-4

文献：Ogawa; Nakato; Tsuchida; Hatayama Chemical and Pharmaceutical Bulletin, 1993 , vol. 41, # 1 p. 108 - 116

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